Results 71 to 80 of about 3,069 (190)

Dentofacial phenotype of non-syndromic tooth agenesis patients with PAX9 mutation

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To evaluate the dentofacial phenotype in non-syndromic tooth agenesis (NSTA) patients with paired box gene 9 (PAX9) mutation.Methods·Patients with NSTA who visited the Department of Second Dental Center of Shanghai Ninth People's Hospital ...
DOU Jiaqi, GAO Jie, BIAN Xiaoling, WANG Feng, DAI Qinggang, WU Yiqun   +5 more
doaj   +1 more source

Expression of interferon regulatory factor 6, muscle segment homeobox 1, paired box gene 9, homeo box B3, and related to tyrosine kinases in human cleft-affected tissue

Journal of Orofacial Sciences, 2016
Background and Aim: Recent studies demonstrate direct roles of different genes during formation of secondary palate, but there are no still data about local expression and distribution of gene products in cleft palate affected human tissue. Thus, the aim
Benita Krivicka-Uzkurele, Mara Pilmane
doaj   +1 more source

Research progress on pathogenic genes and molecular mechanisms of nonsyndromic tooth agenesis

口腔疾病防治, 2020
Tooth agenesis is a common tooth number deficiency that occurs in the tooth-forming process or earlier period of tooth germ development and has a serious impact on the maxillofacial development, aesthetics and masticatory function of patients.
XIE Weihong, YU Dongsheng, ZHAO Wei
doaj   +1 more source

Lysine Acetyltransferase 6 in Health and Disease

MedComm, Volume 6, Issue 12, December 2025.
KAT6A and its paralog KAT6B have emerged as druggable targets for the treatment of malignancies, especially for breast cancer. Recent progress in drug discovery has promoted the development of dual inhibitors targeting KAT6A and KTA6B, which shows potent antitumor efficacy and manageable toxicity.
Yujing Tan, Jiani Wang, Fei Ma
wiley   +1 more source

MSX1 and PAX9 genetic alteration in Malaysian families with hypodontia [PDF]

, 2017
Hypodontia is characterized by the absence of one to six teeth. Malaysia has a high prevalence of hypodontia (2.8%). This study aimed to investigate the MSX1 mutation with clinical variability in Malaysian hypodontia families and to correlate the ...
Lestari, Widya, Idrus, Erik, Ardini, Yunita Dewi, Muhamad Zamil, Nabilah, Mohamed Yussof, Nor Aini   +4 more
core  

MMUUTTAATTIIOONNANALYSIS OF PAX9 GENE IN AFFECTED FAMILY OF HYPODONTIA ATTENDING TERTIARY CARE HOSPITAL OF QUETTA

Pakistan Armed Forces Medical Journal, 2018
Objective: To identify the phenotype and genotype of hypodontia for a Pakistani family with hypodontia and to map the genes locus responsible for this disease. Study Design: Descriptive study.
Muhammad Nawaz, Nasrullah Khan, Agha Muhammad Raza, Nisar Ahmed, Jamil Ahmad   +4 more
doaj   +4 more sources

Agenesis of all third molars in two half siblings

Dentistry 3000, 2015
Tooth agenesis is one of the most common dental anomalies and is influenced by factors including patient genetics. Although there are several specific genes associated with certain patterns of agenesis, there does not seem to be a genetic pattern ...
Jamie A Kaufer
doaj   +1 more source

14q12q13.2 microdeletion syndrome: Clinical characterization of a new patient, review of the literature, and further evidence of a candidate region for CNS anomalies

Molecular Genetics & Genomic Medicine, 2020
Background Chromosome 14q11‐q22 deletion syndrome (OMIM 613457) is a rare contiguous gene syndrome. Two regions of overlap (RO) of the 14q12q21.1 deletion have been identified: a proximal region (RO1), including FOXG1(*164874), NKX2‐1(*600635), and PAX9(*
Emanuela Ponzi, Mattia Gentile, Emanuele Agolini, Emilia Matera, Roberto Palumbi, Antonia Lucia Buonadonna, Antonia Peschechera, Alessandra Gabellone, Maria Fatima Antonucci, Lucia Margari   +9 more
doaj   +1 more source

Harnessing Oxidized Alginate Microgels for Rapid and Self‐Assembling Dental Tissue Organogenesis In Vitro and In Vivo

Small Science, Volume 5, Issue 12, December 2025.
The system employs a high density human dental stem cells‐laden oxidized alginate‐based microgel with a "degrade‐to‐active" paradigm that mimics cellular condensation to enhance cell viability, achieve robust vascularization, and promote subsequent dental organogenesis, which is enabled by rapid degradation along with the elimination of residual ...
Chao Liang, Shuxuan Wu, Ziqi Huang, Zhenzhen Wu, Siyuan Chen, Feiming Li, Karrie Mei‐Yee Kiang, Gilberto Ka‐Kit Leung, Indong Jun, Hwan D. Kim, Ann‐Na Cho, Hee Jung Lee, Honghyun Park, Yiu Yan Leung, Seong Jun Kim, Seil Sohn, Haram Nah, Jae Seo Lee, Il Keun Kwon, Dong‐Nyoung Heo, Sang‐woo Lee, Zhaoming Wu, Sang Jin Lee   +22 more
wiley   +1 more source

Comparative Transcriptomics Reveals a Dual Role of the Epidermal Differentiation Complex in the Skin and the Oesophagus

Experimental Dermatology, Volume 34, Issue 12, December 2025.
ABSTRACT The epidermal differentiation complex (EDC) is a cluster of genes implicated in the control of the skin barrier. However, some EDC genes are also expressed at high levels in the human oesophagus. To determine whether the expression of EDC genes in the oesophagus is evolutionarily conserved, we performed comparative transcriptomic analyses of ...
Attila Placido Sachslehner, Julia Lachner, Veronika Mlitz, Bahar Golabi, Claudia Hess, Wolfgang Sipos, Leopold Eckhart   +6 more
wiley   +1 more source