Results 31 to 40 of about 5,286 (150)

Clinical and molecular characterization of mitochondrial DNA disorders in a group of Argentinian pediatric patients

Molecular Genetics and Metabolism Reports, 2021
Objective: To describe the clinical and molecular features of a group of Argentinian pediatric patients with mitochondrial DNA (mtDNA) disorders, and to evaluate the results of the implementation of a classical approach for the molecular diagnosis of ...
Mariana Amina Loos, Gimena Gomez, Lía Mayorga, Roberto Horacio Caraballo, Hernán Diego Eiroa, María Gabriela Obregon, Carlos Rugilo, Fabiana Lubieniecki, Ana Lía Taratuto, María Saccoliti, Cristina Noemi Alonso, Hilda Verónica Aráoz   +11 more
doaj   +1 more source

Histochemical Characterisation and Gene Expression Analysis of Skeletal Muscles from Maremmana and Aubrac Steers Reared on Grazing and Feedlot Systems

Animals, 2021
This study aimed to characterise the fibre composition of Triceps brachii (TB) and Semimembranosus (SM) muscles from 20 Maremmana (MA) and 20 Aubrac (AU) steers, and the effect of grazing activity in comparison with feedlot system.
Giulia Foggi, Francesca Ciucci, Maria Conte, Laura Casarosa, Andrea Serra, Elisabetta Giannessi, Carla Lenzi, Stefano Salvioli, Giuseppe Conte, Marcello Mele   +9 more
doaj   +1 more source

Prenatal Alcohol Exposure Produces Selective Changes in Neuroimmune Gene Expression Across Brain Regions of Adult Mice. [PDF]

Alcohol Clin Exp Res (Hoboken)
PAE creates a unique inflammatory signature in the mature adult brain with region‐specific changes in genes implicated in glial‐immune function. We report at least 60 differentially expressed genes in different brain regions due to PAE, many of which are associated with neuroimmune function.
Jones AN, Pritha AN, Aguilar AM, Pasmay AA, Carter JR, Mellios N, Noor S.   +6 more
europepmc   +2 more sources

Genetic dysfunction of MT-ATP6 causes axonal Charcot-Marie-Tooth disease [PDF]

Neurology, 2012
Charcot-Marie-Tooth (CMT) disease is the most common inherited neuromuscular disorder, affecting 1 in 2,500 individuals. Mitochondrial DNA (mtDNA) mutations are not generally considered within the differential diagnosis of patients with uncomplicated inherited neuropathy, despite the essential requirement of ATP for axonal function.
Pitceathly, R, Murphy, S, Cottenie, E, Chalasani, A, Sweeney, MG, Woodward, C, Mudanohwo, E, Hargreaves, I, Heales, S, Land, J, Holton, J, Houlden, H, Blake, J, Champion, M, Flinter, F, Robb, SA, Page, R, Rose, M, Palace, J, Crowe, C, Longman, C, Lunn, M, Rahman, S, Reilly, M, Hanna, MG   +24 more
openaire   +4 more sources

The predictive value of peripheral blood cell mitochondrial gene expression in identifying the prognosis in pediatric sepsis at preschool age

Frontiers in Cellular and Infection Microbiology
BackgroundSepsis represents a severe manifestation of infection often accompanied by metabolic disorders and mitochondrial dysfunction. Notably, mitochondrial DNA copy number (mtDNA-CN) and the expression of specific mitochondrial genes have emerged as ...
Siyuan Jing, Yue Zhang, Wanling Zhao, Yifei Li, Yan Wen, Yan Wen   +5 more
doaj   +1 more source

Genetic Diversity in Echinococcus multilocularis From the Plateau Vole and Plateau Pika in Jiuzhi County, Qinghai Province, China

Frontiers in Microbiology, 2018
The Qinghai-Tibet Plateau is a highly endemic area of alveolar echinococcosis where a series of intermediate hosts, especially voles and pikas, are infected with Echinococcus multilocularis. The metacestodes of E.
Jian-qiu Li, Li Li, Yan-lei Fan, Bao-quan Fu, Xing-quan Zhu, Hong-bin Yan, Wan-zhong Jia, Wan-zhong Jia   +7 more
doaj   +1 more source

Generation of a human iPSC line from a patient with Leigh syndrome caused by a mutation in the MT-ATP6 gene

Stem Cell Research, 2016
Human iPSC line L749.1 was generated from fibroblasts of a patient with Leigh syndrome associated with a heteroplasmic mutation in the MT-ATP6 gene. Reprogramming factors OCT4, SOX2, CMYC and KLF4 were delivered using retroviruses.
Teresa Galera-Monge, Francisco Zurita-Díaz, Cristina González-Páramos, Ana Moreno-Izquierdo, Mario F. Fraga, Agustin F. Fernández, Rafael Garesse, M. Esther Gallardo   +7 more
doaj   +1 more source

The complete mitochondrial genome of the booklouse, Liposcelis decolor: insights into gene arrangement and genome organization within the genus Liposcelis. [PDF]

PLoS ONE, 2014
Booklice in the genus Liposcelis are pests of stored grain products. They pose a considerable economic threat to global food security and safety.
Shi-Chun Chen, Dan-Dan Wei, Renfu Shao, Wei Dou, Jin-Jun Wang   +4 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source