Results 51 to 60 of about 5,286 (150)
Mitochondrial Genetic Variation in Iranian Infertile Men with Varicocele [PDF]
International Journal of Fertility and Sterility, 2016 Background: Several recent studies have shown that mitochondrial DNA mutations lead to major disabilities and premature death in carriers. More than 150 mutations in human mitochondrial DNA (mtDNA) genes have been associated with a wide spectrum of ...
Mohammad Mehdi Heidari +5 more
doaj +1 more source
Advanced Science, Volume 13, Issue 49, 3 September 2026.ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun +10 more
wiley +1 more source
Chinese Medical Journal, 2018 Background: Leigh syndrome (LS) is a rare disease caused by mitochondrial defects and has high phenotypic and genotypic heterogeneity. We analyzed the clinical symptoms, neuroimaging, muscular histopathology, and genotypes of 13 Chinese LS patients with ...
Xiao-Lin Yu +7 more
doaj +1 more source
Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature
Advanced Science, Volume 13, Issue 52, 18 September 2026.A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo +14 more
wiley +1 more source
Advanced Science, Volume 13, Issue 54, 28 September 2026.PDGFA/PDGFRα signaling recruits CAFs to OSCC nests, and CAF‐OSCC contact drives tumor budding invasion. Mechanistically, heterotypic adhesion via E‐cadherin/integrin α2β1 activates YAP signaling in OSCC cells, inducing EMT. Concurrently, CAFs transfer mitochondria through TNTs, supplying ATP to fuel invasion.
Yufang Liu +17 more
wiley +1 more source
The m.14484T>C MT‐ND6 Mutation Presenting with a Hereditary Spastic‐Paraparesis Phenotype
Movement Disorders Clinical Practice, EarlyView.
Gabriel Amorelli +4 more
wiley +1 more source
Cancer Medicine, Volume 15, Issue 9, September 2026.ABSTRACT Methotrexate (MTX)‐induced neurotoxicity is a serious complication in pediatric acute lymphoblastic leukemia (ALL), with observed ethnic disparities in risk. To investigate the role of mitochondrial DNA (mtDNA) variation, we performed whole mtDNA sequencing in 94 children with ALL, including 62 Hispanic patients.
Jing Han +9 more
wiley +1 more source
Human Genomics, 2023 Background In recent years, the mitochondria/immune system interaction has been proposed, so that variants of mitochondrial genome and levels of heteroplasmy might deregulate important metabolic processes in fighting infections, such as leprosy.
Felipe Gouvea de Souza +12 more
doaj +1 more source
Ecology and Evolution, Volume 16, Issue 9, September 2026.This study assembled and comparatively analyzed the mitochondrial genomes of P. bournei, P. chekiangensis, and P. zhennan, revealing structural variations and functional conservation among these Phoebe species, thereby providing new data resources for understanding the evolutionary dynamics of plant mitochondrial genomes.
Ting Zou +5 more
wiley +1 more source
Selection in coral mitogenomes, with insights into adaptations in the deep sea
Scientific Reports, 2023 Corals are a dominant benthic fauna that occur across a vast range of depths from just below the ocean’s surface to the abyssopelagic zone. However, little is known about the evolutionary mechanisms that enable them to inhabit such a wide range of ...
Nina I. Ramos +4 more
doaj +1 more source