Results 1 to 10 of about 11,642 (187)

The ubiquitin-specific protease 8 antagonizes melatonin-induced endocytic degradation of MT1 receptor to promote lung adenocarcinoma growth [PDF]

Journal of Advanced Research, 2022
Introduction: The human genome encodes two melatonin receptors (MT1 and MT2) that relay melatonin signals to cellular interior. Accumulating evidence has linked melatonin to multiple health benefits, among which its anticancer effects have become well ...
Qianhui Sun, Jinrui Zhang, Xiaoxi Li, Guoheng Yang, Shaoxuan Cheng, Dong Guo, Qingqing Zhang, Feng Sun, Feng Zhao, Dian Yang, Shanshan Wang, Taishu Wang, Shuyan Liu, Lijuan Zou, Yingqiu Zhang, Han Liu   +15 more
doaj   +2 more sources

Melatonin Reverses the Warburg-Type Metabolism and Reduces Mitochondrial Membrane Potential of Ovarian Cancer Cells Independent of MT1 Receptor Activation [PDF]

Molecules, 2022
Ovarian cancer (OC) is the most lethal gynecologic malignancy, and melatonin has shown various antitumor properties. Herein, we investigated the influence of melatonin therapy on energy metabolism and mitochondrial integrity in SKOV-3 cells and tested ...
Maira Smaniotto Cucielo, Roberta Carvalho Cesário, Henrique Spaulonci Silveira, Letícia Barbosa Gaiotte, Sérgio Alexandre Alcantara dos Santos, Debora Aparecida Pires de Campos Zuccari, Fábio Rodrigues Ferreira Seiva, Russel J. Reiter, Luiz Gustavo de Almeida Chuffa   +8 more
doaj   +2 more sources

Melatonin MT1 Receptor Expression in Luminal Invasive Ductal Breast Carcinoma in Postmenopausal Women [PDF]

Biomolecules
Laboratory and animal studies indicate that melatonin exerts a negative impact on breast cancer progression and metastasis. These actions are both receptor-dependent and -independent.
Leda Pistiolis, Sahar Alawieh, Thorhildur Halldorsdottir, Anikó Kovács, Roger Olofsson Bagge   +4 more
doaj   +2 more sources

The MT1 receptor as the target of ramelteon neuroprotection in ischemic stroke. [PDF]

J Pineal Res, 2023
AbstractStroke is the leading cause of death and disability worldwide. Novel and effective therapies for ischemic stroke are urgently needed. Here, we report that melatonin receptor 1A (MT1) agonist ramelteon is a neuroprotective drug candidate as demonstrated by comprehensive experimental models of ischemic stroke, including a middle cerebral artery ...
Zhang X, Peng B, Zhang S, Wang J, Yuan X, Peled S, Chen W, Ding J, Li W, Zhang A, Wu Q, Stavrovskaya IG, Luo C, Sinha B, Tu Y, Yuan X, Li M, Liu S, Fu J, Aziz-Sultan A, Kristal BS, Alterovitz G, Du R, Zhou S, Wang X.   +24 more
europepmc   +3 more sources

Expression of melatonin receptors in trigeminal and sphenopalatine ganglia: potential targets for primary headache disorders [PDF]

The Journal of Headache and Pain
Background Primary headache disorders such as migraine and cluster headache exhibit circadian and circannual variations in attack onset. Melatonin plays a central role in regulating biological rhythms and likely influences the timing of headache attacks.
Aida Maddahi, Jacob C. A. Edvinsson, Lars Edvinsson, Diana N. Krause   +3 more
doaj   +2 more sources

MT1-MMP inhibition rejuvenates ageing brain and rescues cognitive deficits in obesity [PDF]

Cell Discovery
Obesity has been linked to an increased risk of cognitive impairment and dementia in later life. Although aging and obesity are both associated with cognitive decline, it remains unclear how they interact to affect cognitive function across the lifespan ...
Pallavi Asthana, Liguo Li, Lin Lu, Jiayan Wu, Shuo Zhang, Ningning Li, Sheung Kin Ken Wong, Susma Gurung, Yijing Zhang, Yuwan Lin, Yufeng Peng, Zongtang Xu, Kui Ming Chan, Lixiang Zhai, Aiping Lyu, Zhao-Xiang Bian, Xin Ge, Ashok Iyaswamy, Min Li, Ya Su, Zhongjun Zhou, Pingyi Xu, Hoi Leong Xavier Wong   +22 more
doaj   +2 more sources

Regulation of mitochondrial dynamics and function by melatonin type 1 receptor in parkinson’s disease [PDF]

Cellular and Molecular Life Sciences
Parkinson’s disease (PD) is a neurodegenerative disease characterized by dopaminergic neuron loss and Lewy bodies in the substantia nigra. Abnormal mitochondrial function and accumulated α-synuclein (α-syn) are key etiological factors of PD.
Xiao-Bo Wang, Li-Li Qi, Jian-Min Wang, Yan-Rui Sun, Qian-Kun Lv, Bing-Er Cao, Shu-Min Jiang, Quan-Hong Ma, Chun-Feng Liu, Jun-Yi Liu, Fen Wang   +10 more
doaj   +2 more sources

Melatonin Protects Intact Rat Ovarian Transplantation via the MT1/Nrf2/ARE Pathway [PDF]

Cells
Cryopreservation and transplantation of intact ovaries offer a promising approach to fertility restoration in cancer patients. However, ischemia–reperfusion injury following transplantation significantly impairs graft function.
Lingyun Xie, Shanshan Wang, Yuling Wu, Xuyin Zhang, Yan Ding   +4 more
doaj   +2 more sources

Sperm freezability is associated with melatonin receptor expression in the sperm plasma membrane of Saanen goat bucks (Capra hircus) [PDF]

Veterinary World
Background and Aim: Cryopreservation is an essential assisted reproductive technology for preserving valuable animal genetics; however, it induces osmotic and oxidative stress that compromises sperm quality.
Alberto J. Cardenas-Padilla, Alfredo Medrano   +1 more
doaj   +2 more sources

Melatonin regulates rabbit sperm motility and kinematics via the MT1/PKC signaling pathway [PDF]

Animal Bioscience
Objective Melatonin, a highly conserved molecule, plays an essential role in various physiological functions. Research suggests that incorporating melatonin into semen extender enhances livestock sperm viability.
Chongchong Wang, Yanyan Zhang, Shiwen He, Biao Jiang, Jinglei Huang, Hui Peng   +5 more
doaj   +2 more sources