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Melatonin Receptors: A Key Mediator in Animal Reproduction
Veterinary Sciences, 2022 Melatonin, a hormone produced by the mammalian pineal gland, influences various physiological activities, many of which are related to animal reproduction, including neuroendocrine function, rhythm regulation, seasonal behavior, gonadogenesis, gamete ...
Yuan Gao +3 more
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A Review of Melatonin, Its Receptors and Drugs
Eurasian Journal of Medicine, 2019 After a Turkish scientist took Nobel Prize due to his contributions to understand clock genes, melatonin, closely related to these genes, may begin to shine.
Mucahit Emet +5 more
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Structural insights into melatonin receptors [PDF]
The FEBS Journal, 2019 The long‐anticipated high‐resolution structures of the human melatonin G protein‐coupled receptors MT1 and MT2, involved in establishing and maintaining circadian rhythm, were obtained in complex with two melatonin analogs and two approved anti‐insomnia and antidepression drugs using X‐ray free‐electron laser serial femtosecond crystallography.
Benjamin Stauch +2 more
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Scientific Reports, 2017 Understanding the function of orphan G protein-coupled receptors (GPCRs), whose cognate ligand is unknown, is of major importance as GPCRs are privileged drug targets for many diseases. Recent phylogenetic studies classified three orphan receptors, GPR61,
Atsuro Oishi +5 more
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Human gastroenteropancreatic expression of melatonin and its receptors MT1 and MT2. [PDF]
PLoS ONE, 2015 The largest source of melatonin, according to animal studies, is the gastrointestinal (GI) tract but this is not yet thoroughly characterized in humans.
Fanny Söderquist +2 more
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Is Melatonin the Cornucopia of the 21st Century?
Antioxidants, 2020 Melatonin, an indoleamine hormone produced and secreted at night by pinealocytes and extra-pineal cells, plays an important role in timing circadian rhythms (24-h internal clock) and regulating the sleep/wake cycle in humans.
Nadia Ferlazzo +7 more
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Melatonin receptor structure and signaling
Journal of Pineal ResearchAbstractMelatonin (5‐methoxy‐N‐acetyltryptamine) binds with high affinity and specificity to membrane receptors. Several receptor subtypes exist in different species, of which the mammalian MT1 and MT2 receptors are the best‐characterized. They are members of the G protein‐coupled receptor superfamily, preferentially coupling to Gi/o proteins but also ...
Okamoto, Hiroyuki +4 more
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Melatonin receptors and Per1 expression in the inferior olivary nucleus of the Sapajus apella monkey
Frontiers in Neuroscience, 2022 Melatonin is a transducer of photic environmental information and participates in the synchronization of various physiological and behavioral phenomena.
Marcos Donizete Junior Granado +9 more
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Membrane Melatonin Receptors Activated Cell Signaling in Physiology and Disease
International Journal of Molecular Sciences, 2021 The pineal hormone melatonin has attracted great scientific interest since its discovery in 1958. Despite the enormous number of basic and clinical studies the exact role of melatonin in respect to human physiology remains elusive.
G. Nikolaev, R. Robeva, R. Konakchieva
semanticscholar +1 more source
Modeling the Heterodimer Interfaces of Melatonin Receptors
Frontiers in Cellular Neuroscience, 2021 Melatonin receptors are Class A G protein-coupled receptors (GPCRs) that regulate a plethora of physiological activities in response to the rhythmic secretion of melatonin from the pineal gland.
Lap Hang Tse +3 more
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