Results 11 to 20 of about 11,642 (187)

Identification of amino acid residues in the MT-loop of MT1-MMP critical for its ability to cleave low-density lipoprotein receptor

Frontiers in Cardiovascular Medicine, 2022
Low-density lipoprotein receptor (LDLR) mediates clearance of plasma LDL cholesterol, preventing the development of atherosclerosis. We previously demonstrated that membrane type 1-matrix metalloproteinase (MT1-MMP) cleaves LDLR and exacerbates the ...
Maggie Wang, Adekunle Alabi, Hong-mei Gu, Govind Gill, Ziyang Zhang, Suha Jarad, Xiao-dan Xia, Xiao-dan Xia, Yishi Shen, Gui-qing Wang, Da-wei Zhang   +10 more
doaj   +1 more source

Recombinant human melatonin receptor MT1 isolated in mixed detergents shows pharmacology similar to that in mammalian cell membranes. [PDF]

PLoS ONE, 2014
The human melatonin MT1 receptor-belonging to the large family of G protein-coupled receptors (GPCRs)-plays a key role in circadian rhythm regulation and is notably involved in sleep disorders and depression.
Christel Logez, Sylvie Berger, Céline Legros, Jean-Louis Banères, William Cohen, Philippe Delagrange, Olivier Nosjean, Jean A Boutin, Gilles Ferry, Frédéric Simonin, Renaud Wagner   +10 more
doaj   +1 more source

Melatonin abolished proinflammatory factor expression and antagonized osteoarthritis progression in vivo

Cell Death and Disease, 2022
Progressive structural changes in osteoarthritis (OA) involve synovial inflammation and angiogenesis, as well as activation of the proinflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin (IL)-8, and the angiogenic factor vascular ...
Shan-Chi Liu, Chun-Hao Tsai, Yu-Han Wang, Chen-Ming Su, Hsi-Chin Wu, Yi-Chin Fong, Shun-Fa Yang, Chih-Hsin Tang   +7 more
doaj   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Regulation of pituitary MT1 melatonin receptor expression by gonadotrophin-releasing hormone (GnRH) and early growth response factor-1 (Egr-1): in vivo and in vitro studies. [PDF]

PLoS ONE, 2014
Melatonin receptor expression exhibits profound developmental changes through poorly understood mechanisms. In mammals, a current model suggests that pubertal reactivation of gonadotrophin-releasing hormone (GnRH) secretion down-regulates MT1 melatonin ...
Sung-Eun Bae, Ian K Wright, Cathy Wyse, Nathalie Samson-Desvignes, Pascale Le Blanc, Serge Laroche, David G Hazlerigg, Jonathan D Johnston   +7 more
doaj   +1 more source

Melatonin Alleviates the Suppressive Effect of Hypoxanthine on Oocyte Nuclear Maturation and Restores Meiosis via the Melatonin Receptor 1 (MT1)-Mediated Pathway

Frontiers in Cell and Developmental Biology, 2021
It is well known that hypoxanthine (HX) inhibits nuclear maturation of oocytes by elevating the intracellular cAMP level, while melatonin (MT) is a molecule that reduces cAMP production, which may physiologically antagonize this inhibition and restore ...
Jing Wang, Zhiyong Zhuo, Zhiyong Zhuo, Xiao Ma, Yunjie Liu, Jing Xu, Changjiu He, Yao Fu, Feng Wang, Pengyun Ji, Lu Zhang, Guoshi Liu   +11 more
doaj   +1 more source

Expression of the MT1 Melatonin Receptor in Ovarian Cancer Cells [PDF]

International Journal of Molecular Sciences, 2014
Ovarian cancer (OC) is the leading cause of death among women with genital tract disorders. Melatonin exhibits oncostatic properties which it may effect through binding to its membrane receptor, MT1. The aim of this study was to determine the expression of MT1 in OC cells and to correlate this with clinical and pathological data.
Karolina Jablonska, Bartosz Pula, Agata Zemla, Christopher Kobierzycki, Witold Kedzia, Ewa Nowak-Markwitz, Marek Spaczynski, Maciej Zabel, Marzenna Podhorska-Okolow, Piotr Dziegiel   +9 more
openaire   +2 more sources

Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks. [PDF]

PLoS ONE, 2016
Melatonin is rhythmically secreted by both the pineal gland and retina in a circadian fashion, with its peak synthesis occurring during the night. Once synthesized, melatonin exerts its effects by binding to two specific G-protein coupled receptors ...
Sharon Owino, Susana Contreras-Alcantara, Kenkichi Baba, Gianluca Tosini   +3 more
doaj   +1 more source

Distribution of Melatonin MT1 Receptor Immunoreactivity in Human Retina [PDF]

Journal of Histochemistry & Cytochemistry, 2002
Melatonin is synthesized in the pineal gland and retina during the night. Retinal melatonin is believed to be involved in local cellular modulation and in regulation of light-induced entrainment of circadian rhythms. The present study provides the first immunohistochemical evidence for the localization of melatonin 1a-receptor (MT1) in human retina of
Savaskan, Egemen, Wirz‐Justice, Anna, Olivieri, Gianfranco, Pache, Mona, Kräuchi, Kurt, Brydon, Lena, Jockers, Ralf, Müller-Spahn, Franz, Meyer, Peter   +8 more
openaire   +3 more sources

Activation of MT1/MT2 to Protect Testes and Leydig Cells against Cisplatin-Induced Oxidative Stress through the SIRT1/Nrf2 Signaling Pathway

Cells, 2022
There is growing concern that chemotherapy drugs can damage Leydig cells and inhibit the production of testosterone. Increasing evidence shows that melatonin benefits the reproductive process. This study mainly explores the protective effect and possible
Junqiang Zhang, Yuan Fang, Dongdong Tang, Xingyu Xu, Xiaoqian Zhu, Shusheng Wu, Hui Yu, Huiru Cheng, Ting Luo, Qunshan Shen, Yang Gao, Cong Ma, Yajing Liu, Zhaolian Wei, Xiaoyu Chen, Fangbiao Tao, Xiaojin He, Yunxia Cao   +17 more
doaj   +1 more source