Results 21 to 30 of about 11,642 (187)

Melatonin Transmits Photoperiodic Signals through the MT1 Melatonin Receptor [PDF]

The Journal of Neuroscience, 2009
Melatonin transmits photoperiodic signals that regulate reproduction. Two melatonin receptors (MT1 and MT2) have been cloned in mammals and additional melatonin binding sites suggested, but the receptor that mediates the effects of melatonin on the photoperiodic gonadal response has not yet been identified. We therefore investigated in mice whether and
Shinobu, Yasuo, Takashi, Yoshimura, Shizufumi, Ebihara, Horst-Werner, Korf   +3 more
openaire   +2 more sources

Melatonin MT1 receptors as a target for the psychopharmacology of bipolar disorder: A translational study

Pharmacological Research, 2023
The treatment of bipolar disorder (BD) still remains a challenge. Melatonin (MLT), acting through its two receptors MT1 and MT2, plays a key role in regulating circadian rhythms which are dysfunctional in BD.
Margherita Tassan Mazzocco, Claudia Pisanu, Luigi Russo, Clementina Acconcia, Marco Cambiaghi, Sofia De Girolamo, Alessio Squassina, Laura Cherchi, Elena Monzani, Francesca Scebba, Debora Angeloni, Danilo De Gregorio, Sofia Nasini, Stefano Dall’Acqua, Stefania Sut, Federico Suprani, Mario Garzilli, Beatrice Guiso, Vittoria Pulcinelli, Maria Novella Iaselli, Ilaria Pinna, Giulia Somaini, Laura Arru, Carolina Corrias, Pasquale Paribello, Federica Pinna, Gabriella Gobbi, Flavia Valtorta, Bernardo Carpiniello, Mirko Manchia, Stefano Comai   +30 more
doaj   +1 more source

The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization [PDF]

The EMBO Journal, 2006
One-third of the approximately 400 nonodorant G protein-coupled receptors (GPCRs) are still orphans. Although a considerable number of these receptors are likely to transduce cellular signals in response to ligands that remain to be identified, they may also have ligand-independent functions.
Levoye, Angélique, Dam, Julie, Ayoub, Mohammed, Guillaume, Jean-Luc, Couturier, Cyril, Delagrange, Philippe, Jockers, Ralf   +6 more
openaire   +3 more sources

Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of insulin receptor

Nature Communications, 2022
Insulin sensitivity declines with age via unclear mechanisms. Here, the authors show that the activity of membrane type 1 matrix metalloproteinase (MT1-MMP) is increased with ageing, leading to cleavage of the insulin receptor, and show that metabolic ...
Xuanming Guo, Pallavi Asthana, Susma Gurung, Shuo Zhang, Sheung Kin Ken Wong, Samane Fallah, Chi Fung Willis Chow, Sijia Che, Lixiang Zhai, Zening Wang, Xin Ge, Zhixin Jiang, Jiayan Wu, Yijing Zhang, Xiaoyu Wu, Keyang Xu, Cheng Yuan Lin, Hiu Yee Kwan, Aiping Lyu, Zhongjun Zhou, Zhao-Xiang Bian, Hoi Leong Xavier Wong   +21 more
doaj   +1 more source

Modeling the Heterodimer Interfaces of Melatonin Receptors

Frontiers in Cellular Neuroscience, 2021
Melatonin receptors are Class A G protein-coupled receptors (GPCRs) that regulate a plethora of physiological activities in response to the rhythmic secretion of melatonin from the pineal gland.
Lap Hang Tse, Yung Hou Wong, Yung Hou Wong, Yung Hou Wong   +3 more
doaj   +1 more source

The Melatonin MT1 Receptor Axis Modulates Mutant Huntingtin-Mediated Toxicity [PDF]

The Journal of Neuroscience, 2011
Melatonin mediates neuroprotection in several experimental models of neurodegeneration. It is not yet known, however, whether melatonin provides neuroprotection in genetic models of Huntington's disease (HD). We report that melatonin delays disease onset and mortality in a transgenic mouse model of HD.
Xin, Wang, Ana, Sirianni, Zhijuan, Pei, Kerry, Cormier, Karen, Smith, Jiying, Jiang, Shuanhu, Zhou, Hui, Wang, Rong, Zhao, Hiroko, Yano, Jeong Eun, Kim, Wei, Li, Bruce S, Kristal, Robert J, Ferrante, Robert M, Friedlander   +14 more
openaire   +2 more sources

TIMP-2 Interaction with MT1-MMP Activates the AKT Pathway and Protects Tumor Cells from Apoptosis. [PDF]

PLoS ONE, 2015
Membrane-type 1 matrix metalloproteinase (MT1-MMP), a transmembrane proteinase with an extracellular catalytic domain and a short cytoplasmic tail, degrades a variety of extracellular matrix (ECM) components.
Cristina Valacca, Evelyne Tassone, Paolo Mignatti   +2 more
doaj   +1 more source

MT1 Melatonin Receptor Expression in Warthin’s Tumor

Pathology & Oncology Research, 2012
We contribute the first immunohistochemical study of MT1 melatonin receptor in Warthin's tumor and normal parotid gland. All 14 Warthin's tumors studied showed intense cytoplasmic positivity for MT1 receptor in all cylindrical epithelial cells lining spaces and a less intense positivity in basal cells.
Jose, Aneiros-Fernandez, Salvador, Arias-Santiago, Borja, Arias-Santiago, Maria, Herrero-Fernández, V, Carriel, Jose, Aneiros-Cachaza, Antonio, López-Valverde, Antonio, Cutando-Soriano   +7 more
openaire   +2 more sources

Differential Function of Melatonin MT1 and MT2 Receptors in REM and NREM Sleep

Frontiers in Endocrinology, 2019
The pathophysiological function of the G-protein coupled melatonin MT1 and MT2 receptors has not yet been well-clarified. Recent advancements using selective MT1/ MT2 receptor ligands and MT1/MT2 receptor knockout mice have suggested that the activation ...
Gabriella Gobbi, Stefano Comai, Stefano Comai   +2 more
doaj   +1 more source

Distribution and colocalization of melatonin 1a-receptor and NADPH-d in the trigeminal system of rat [PDF]

PeerJ, 2019
Melatonin and nitric oxide (NO) are involved in orofacial signal processing in the trigeminal sensory system. The aim of the present study was to examine the distribution of melatonin 1a-receptor (MT1) and its colocalization with nicotinamide adenine ...
Yifan He, Wenguo Fan, Yue Xu, Yong liang Liu, Hongwen He, Fang Huang   +5 more
doaj   +2 more sources