Results 41 to 50 of about 11,642 (187)

Clinical usefulness of melatonin MT1 and MT2 receptor agonists in the treatment of sleep disorders and depression

Medycyna Ogólna i Nauki o Zdrowiu, 2022
Introduction and objective Melatonin is the most important compound produced by the pineal gland. Its daily secretion cycle is responsible for the normal rhythm of sleep and wakefulness.
Sara Hmaidan, Ewa Gibuła-Tarłowska, Paweł Grochecki, Ewa Kędzierska   +3 more
doaj   +1 more source

A novel signaling transduction pathway of melatonin on lactose synthesis in cows via melatonin receptor 1 (MT1) and prolactin receptor (PRLR) [PDF]

PeerJ, 2023
In the current study, we explored the relationship between melatonin and lactose synthesis in in vivo and in vitro conditions. We found that long-term melatonin feeding to the dairy cows significantly reduced the milk lactose content in a dose dependent ...
Yunjie Liu, Songyang Yao, Qinggeng Meng, Xuening Liu, Huigang Han, Chunli Kan, Tiankun Wang, Wenjuan Wei, Shujing Li, Wenli Yu, Zengyuan Zhao, Changwang He, Guoshi Liu   +12 more
doaj   +2 more sources

Rhythmic Expression of Functional MT1 Melatonin Receptors in the Rat Adrenal Gland [PDF]

Endocrinology, 2007
We previously demonstrated that melatonin is involved in the regulation of adrenal glucocorticoid production in diurnal primates through activation of MT1 membrane-bound melatonin receptors. However, whether melatonin has a similar role in nocturnal rodents remains unclear.
Richter, Hans G., Torres Farfán, Claudia, García Sesnich, Jocelyn, Abarzúa Catalán, Lorena, Henríquez Luna, Mauricio, Alvarez Felmer, Mauro, Gaete, Fernando, Rehren, Germán E., Serón Ferré, María   +8 more
openaire   +4 more sources

Removal of melatonin receptor type 1 signalling induces dyslipidaemia and hormonal changes in mice subjected to environmental circadian disruption

Endocrinology, Diabetes & Metabolism, 2021
Background Melatonin is a hormone secreted by the pineal gland in a circadian rhythmic manner with peak synthesis at night. Melatonin signalling was suggested to play a critical role in metabolism during the circadian disruption.
Cynthia Tchio, Kenkichi Baba, Giuseppe Piccione, Gianluca Tosini   +3 more
doaj   +1 more source

Mammalian Melatonin Agonist Pharmaceuticals Stimulate Rhomboid Proteins in Plants

Biomolecules, 2022
Melatonin is a human neurotransmitter and plant signalling metabolite that perceives and directs plant metabolism. The mechanisms of melatonin action in plants remain undefined.
Lauren A. E. Erland, Christopher R. Dumigan, Jillian A. Forsyth, Liubov Frolova, Adam B. Yasunaga, Winnie Pun, Isaac T. S. Li, Michael K. Deyholos, Susan J. Murch   +8 more
doaj   +1 more source

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source

MT1 and MT2 melatonin receptors play opposite roles in brain cancer progression

Journal of Molecular Medicine, 2021
Primary brain tumors remain among the deadliest of all cancers. Glioma grade IV (glioblastoma), the most common and malignant type of brain cancer, is associated with a 5-year survival rate of
G. S. Kinker, L. H. Ostrowski, P. A. C. Ribeiro, R. Chanoch, S. M. Muxel, I. Tirosh, G. Spadoni, S. Rivara, V. R. Martins, T. G. Santos, R. P. Markus, P. A. C. M. Fernandes   +11 more
openaire   +3 more sources

Single‐Cell RNA Sequencing of Human Lung Tissues Reveals Metallothionein‐Positive T Cells as a Novel Potential Marker of Susceptibility to Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
Using single‐cell RNA sequencing of lung samples and flow cytometry of peripheral blood, we identified a novel T cell subset with high metallothionein (MT) expression. These MT‐high T cells suppress CD8+ T cell cytotoxicity and are progressively depleted from healthy controls to chronic obstructive pulmonary disease (COPD) patients, positioning them as
Zengqing Liu, Xiaoxia Ren, Mi Mu, Huanyu Long, Jialu Lv, Zhihong Feng, Jie Liu, Jiajia Wang, Hui Deng, Fanyu Shi, Muzhi Zhang, Ruoyang Zhang, Yang Liu, Mengyu Xu, Yang Fan, Zengtao Wang, Zhe Lv, Yan Chen, Chris J. Corrigan, Ying Sun, Yahong Chen, Chen Chen, Ye Cui, Wei Wang   +23 more
wiley   +1 more source

Integrating classical and quantum mechanics in melatonin receptors for structure-guided drug design

Academia Biology
Although melatonin receptor agonists are acknowledged for their therapeutic potential for managing sleep problems, the structural optimization of these compounds is made challenging by variations in crystallographic data.
Gabriela de Lima Menezes, Gabriel Vinícius Rolim da Silva, Katyanna Sales Bezerra, Marielena Vogel Saivish, Clara Sales Gurgel Ribeiro Dantas, Douglas Soares Galvão, John Fontenele Araújo, Jonas Ivan Nobre Oliveira, Roosevelt Alves da Silva, Umberto Laino Fulco   +9 more
doaj   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source