Results 81 to 90 of about 11,642 (187)

Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem, Atif Ali, Wajid Ali, Yuying Cheng, Zhibin Yan, Chaoyi Xia, Chenguang Liu, Caiyun Fu, Yiren Hu, Xi Wang   +9 more
wiley   +1 more source

Melatonin alleviates aging-related heart failure through melatonin receptor 1A/B knockout in mice

Heliyon
Age-related cardiovascular diseases continue to be important issues that contribute to the societal burden. Unveiling the molecular mechanisms underlying age-related cardiovascular diseases provides novel opportunities to delay aging and facilitate early
Zhenyu Feng, Yang Liu, Yijin Yang, Jie Bai, Qiu-yue Lin, Yun-long Xia, Yunpeng Xie   +6 more
doaj   +1 more source

Melatonin pretreatment alleviates the long-term synaptic toxicity and dysmyelination induced by neonatal Sevoflurane exposure via MT1 receptor-mediated Wnt signaling modulation. [PDF]

J Pineal Res, 2021
Liang L, Zeng T, Zhao Y, Lu R, Guo B, Xie R, Tang W, Zhang L, Mao Z, Yang X, Wu S, Wang Y, Zhang H.   +12 more
europepmc   +1 more source

Correlation between sleep problems and morning serum melatonin and ferritin levels in Japanese 5‐year‐old children with autism spectrum disorder

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 1, March 2026.
Abstract Aim Children with autism spectrum disorder (ASD) are more likely to have sleep problems. Few studies have investigated the relationship between sleep problems and blood melatonin and ferritin levels. The objective of this study was to determine the correlation between sleep problems and morning serum melatonin and ferritin levels, and the ...
Ai Terui, Manabu Saito, Asami Kuki, Shuji Shimoyama, Yui Sakamoto, Kazutaka Yoshida, Ayako Osato, Kazuhiko Nakamura   +7 more
wiley   +1 more source

Impact of Peri‐Implant Phenotype on Implant Therapy Outcomes: A 5‐Year Cohort Analysis on Soft Tissue—Level Implants

Journal of Clinical Periodontology, Volume 53, Issue 3, Page 394-406, March 2026.
ABSTRACT Objective To investigate the associations between peri‐implant phenotype characteristics and long‐term outcomes of soft tissue–level implants. Methods Twenty‐five tissue‐level implants from a previous controlled clinical trial were evaluated at 1‐ and 5‐year follow‐ups after crown delivery.
Hamoun Sabri, Parham Hazrati, Lorenzo Tavelli, Carlos Garaicoa‐Pazmino, Javier Calatrava, Hom‐Lay Wang, Shayan Barootchi   +6 more
wiley   +1 more source

Pineal and cortical melatonin receptors MT1 and MT2 are decreased in Alzheimer’s disease

European Journal of Histochemistry, 2009
The pineal hormone melatonin is involved in physiological transduction of temporal information from the light dark cycle to circadian and seasonal behavioural rhythms, as well as possessing neuroprotective properties.
P Brunner, N Sözer-Topcular, R Jockers, R Ravid, D Angeloni, F Fraschini   +5 more
doaj   +1 more source

Sleep quality and sleepiness in adults with multiple myeloma. Is melatonin a potential treatment?

Physiological Reports, Volume 14, Issue 5, March 2026.
Abstract Sleep disturbances significantly impact quality of life in cancer patients, yet remain poorly characterized in multiple myeloma (MM). This observational study aimed to characterize sleep profiles in MM patients and evaluate the therapeutic potential of exogenous melatonin.
Mariana Fiori, Evellyn M. de Azevedo, Lais S. Rodrigues, Kamily S. Turt, Daniel Pacheco Bruschi, Marcelo M. S. Lima   +5 more
wiley   +1 more source

Chimeric Melatonin mt1 and Melatonin-related Receptors [PDF]

Journal of Biological Chemistry, 2000
Shaun Conway, Janice E. Drew, Elaine S. Mowat, Perry Barrett, Philippe Delagrange, Peter J. Morgan   +5 more
openaire   +1 more source

Chimeric melatonin mt1 and melatonin-related receptors. Identification of domains and residues participating in ligand binding and receptor activation of the melatonin mt1 receptor.

The Journal of biological chemistry, 2000
Melatonin receptors bind and become activated by melatonin. The melatonin-related receptor, despite sharing considerable amino acid sequence identity with melatonin receptors, does not bind melatonin and is currently an orphan G protein-coupled receptor.
S, Conway, J E, Drew, E S, Mowat, P, Barrett, P, Delagrange, P J, Morgan   +5 more
openaire   +1 more source

Melatonin MT1 and MT2 receptor expression in Parkinson's disease.

Medical science monitor : international medical journal of experimental and clinical research, 2010
Idiopathic Parkinson disease (PD) is a multi-system disorder with a multifactorial etiology and diverse clinical phenotype. Selective, regional dopaminergic neuronal degeneration in the substantia nigra and other CNS areas including the amygdala are observed in all patients.
Nikhil, Adi, Deborah C, Mash, Yousuf, Ali, Carlos, Singer, Lina, Shehadeh, Spyridon, Papapetropoulos   +5 more
openaire   +1 more source