Results 161 to 170 of about 192,422 (249)

The sorting nexin Snx21 promotes flotillin‐mediated endocytosis

The FEBS Journal, EarlyView.
In this study, we describe a novel function of the previously uncharacterized Snx21 protein as a specific positive regulator of flotillin‐mediated endocytic trafficking. Snx21 is recruited to endosomal membranes via binding to PI(3)P, and it colocalizes with flotillins on the surface of late endosomes.
Tamás Maruzs, Enikő Lakatos, Dalma Feil‐Börcsök, Gábor Juhász, Regina Mező, Asha Kiran Maddali, András Blastyák, Aladár Pettkó‐Szandtner, Hajnalka Laczkó‐Dobos, Gábor Juhász   +9 more
wiley   +1 more source

Acquired Resistance to the PRMT5 Inhibitor Confers Collateral Sensitivity to MEK Inhibition in <i>MTAP</i>-Null Non-Small Cell Lung Cancer. [PDF]

Biomolecules
Fu R, Wang Y, Rehman I, Bedford E, Sharif S, Nguyen ND, Powell RT, Adams A, Liu W, Wang S, He W, Lu Y, Liu B, Shah PA, Ahnert JR, Chen T, Peng W, Stephan CC, Liu X, Bedford MT, Xu H.   +20 more
europepmc   +1 more source

TOP1MT rs2293925 is an enhancer‐active regulatory SNP that shapes mitochondrial R‐loop dynamics

The FEBS Journal, EarlyView.
This study shows how a common genetic variant of mitochondrial topoisomerase 1 (TOP1MT rs2293925) can influence mitochondrial gene regulation, DNA topology, and formation of noncanonical nucleic acid structures such as R‐loops. By linking this enhancer‐active variant to mitochondrial nucleic acid stress in cellular contexts relevant to amyotrophic ...
Dóra Varga, Zsolt Ráduly, Beáta Boros‐Oláh, Éva Nagy, Zsolt Karányi, László Halász, Bálint László Bálint, György Vámosi, Emese Tóth, Péter Bai, Serena Santangelo, Patrizia Bossolasco, Antonia Ratti, Vincent Géli, Yves Pommier, Lóránt Székvölgyi   +15 more
wiley   +1 more source

Identification of Rice m⁶A Methyltransferase Complex Subunits MTA/MTB and Their Effects on Heading Date and Grain Weight. [PDF]

Plants (Basel)
Li C, Zhang M, Zhao D, Cao X, Wang H, Liu M, Zhang T, Wang W, Wu J.   +8 more
europepmc   +1 more source

Tankyrase‐2 regulates adipocyte differentiation through AMPK/mTOR signaling

The FEBS Journal, EarlyView.
Tankyrase 2 (TNKS2), a PARP family member, underpins adipocyte differentiation. TNKS2 controls LKB1 protein level, and consequently, the activity of the mTOR/AMPK system and adipocyte differentiation through a layered process. Pharmacological inhibition of TNKS2 leaves other PARPs and DNA repair active and therefore represents a novel target in ...
Boglarka Rauch, Gyula Ujlaki, Szilard Poliska, Nakayi Murahwa, Patrik Kovacs, Aladar Pettko‐Szandtner, Karen Uray, Peter Bai   +7 more
wiley   +1 more source

Adhesive Bonding to Hydraulic Gel-Forming Calcium Silicate-Based Cements: Effects of Cement Type, Adhesive Strategy, and Restoration Timing. [PDF]

Gels
Akın Tartuk G, Yeniçeri Özata M, Kaya S.   +2 more
europepmc   +1 more source

The diagnostic order of migraine–depression comorbidity associates with physical, mental, and social disability

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background There is a known bidirectional association between migraine and depression; however, potential effects of the diagnostic trajectory of the diseases are not known. Therefore, we investigated the association of the diagnostic order of migraine and depression with the physical and mental health status of groups with ...
Daniel Baksa, Nora Eszlari, Dora Torok, Tamas Nagy, Gabor Hullam, Peter Petschner, Gyorgy Bagdy, Gabriella Juhasz   +7 more
wiley   +1 more source

Comparison of Sealing Ability of Biodentine, Biostructure Mineral Trioxide Aggregate, Theracal LC, and Bio-C Repair as Perforation Repair Material: An Inverted Laser Scanning Confocal Microscopic Study. [PDF]

Int J Clin Pediatr Dent
Devi LM, Yadav G, Rai A, Saha S, Dhinsa K, Sharma A.   +5 more
europepmc   +1 more source

Never Mind the Bollards: Exploring the Role of GCHQ, MI5, and the National Technical Authorities in UK Security Markets

The Howard Journal of Crime and Justice, EarlyView.
ABSTRACT The cultures and governance of security markets in the United Kingdom are often characterised through a paradoxical narrative of simultaneous state retreat and progressive advance. In the face of repeated recent high‐profile security failures, and global changes in material political economy, we argue that UK security governance is adapting to
Ben Collier, Jamie Buchan
wiley   +1 more source

Bone Healing Response to Different Concentrations of Nano-Hydroxyapatite Incorporated into Mineral Trioxide Aggregate and Bioceramic Sealers. [PDF]

Polymers (Basel)
Abdulhaq AA, Mohammad CA, Amin BK.
europepmc   +1 more source