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International Journal of Legal Medicine, 2001
We have compiled a database of mitochondrial DNA (mtDNA) control region, hypervariable regions 1 (HVR1) and 2 (HVR2) sequences of a total of 14,138 individuals compiled from 103 mtDNA publications before 1 January 2000, 13 data sets published in 2000 and 2001 and 2 unpublished data sets of Iraqi Kurds and Indians from Kerala.
A, Röhl +3 more
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We have compiled a database of mitochondrial DNA (mtDNA) control region, hypervariable regions 1 (HVR1) and 2 (HVR2) sequences of a total of 14,138 individuals compiled from 103 mtDNA publications before 1 January 2000, 13 data sets published in 2000 and 2001 and 2 unpublished data sets of Iraqi Kurds and Indians from Kerala.
A, Röhl +3 more
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mtDNA GeneExtractor: A computer tool for mtDNA gene/region information extraction
Mitochondrion, 2009The analysis of considerable numbers of DNA sequences is largely dependent on the development of simple software tools for automatically process the genetic data deposited on public databases. However, there are some difficulties in the automation process due to diverse synonyms being used as qualifiers for genes and some inconsistencies in gene ...
Freitas, F +3 more
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mtDNA heterogeneity inPanulirus argus
Experientia, 1983Restriction endonuclease analysis of mtDNA polymorphisms inPanulirus argus has revealed significant heterogeneity and possible species subdivision.
M, McLean, C K, Okubo, M L, Tracey
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Forensic mass screening using mtDNA
International Journal of Legal Medicine, 2006At the forensic autopsy of a sexual murder victim, some trace hairs, possibly belonging to the perpetrator, were saved. Initially, the analysis of a pubic hair shaft only revealed the presence of the mitochondrial (mt) DNA haplotype profile consisting of the (CA)(6) allele and the complete hypervariable region 1 (HV1) and 2 (HV2) sequence.
Reinhard, Szibor +4 more
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Visualization of mtDNA Using FISH
2023Proper mitochondrial DNA (mtDNA) levels are critical for many cellular biological functions and are associated with aging and many mitochondria disorders. Defects in core subunits of the mtDNA replication machinery lead to decreased mtDNA levels. Other indirect mitochondrial contexts including ATP concentration, lipid composition, and nucleotide ...
Xie, Xie, Xuefeng, Zhu
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EMPOP—A forensic mtDNA database
Forensic Science International: Genetics, 2007Mitochondrial DNA databases stand as the basis for frequency estimations of mtDNA sequences that became relevant in a case. The establishment of mtDNA databases sounds trivial; however, it has been shown in the past that this undertaking is prone to error for several reasons, particularly human error.
Walther, Parson, Arne, Dür
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mtDNA Investigations After Differential Lysis
Journal of Forensic Sciences, 2005Abstract In order to gain information regarding the ethnic origin of an unknown offender in a murder case it was necessary to sequence the HV1 and 2 regions of the mitochondrial DNA (mtDNA). The only evidentiary material that could be linked to the suspect was DNA, extracted from spermatozoa after differential lysis.
Katja D, Anslinger +3 more
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Endogenous oxidative damage of mtDNA
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1999Almost a decade ago, based on analytical measurements of the oxidative DNA adduct 8-oxo-deoxyguanosine (oxo8dG), it was reported that mitochondrial DNA suffers greater endogenous oxidative damage than nuclear DNA. The subsequent discovery that somatic deletions of mitochondrial DNA occur in humans, and that they do so to the greatest extent in ...
K B, Beckman, B N, Ames
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mtDNA maintenance: disease and therapy
2020Mitochondrial maintenance disorders present as a spectrum ranging from severe infantile multisystemic syndrome to childhood or adult tissue-specific diseases. Hallmark is the variable association of qualitative (point mutations, multiple deletions) or quantitative (copy number reduction) molecular genetic defect of mitochondrial DNA (mtDNA ...
Quadalti C., Garone C.
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Detection of Mutations in mtDNA
2007Publisher Summary This chapter focuses on the detection of mutations in mitochondrial DNA (mtDNA). There are several distinctive features of mtDNA that are relevant to the understanding of mtDNA-related diseases. An ever-increasing number of mitochondrial diseases with distinct clinical phenotypes have been associated with mutations in mtDNA, almost ...
Ali, Naini, Sara, Shanske
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