Results 161 to 170 of about 427,120 (360)

Multiphysics‐Driven Assembly of Biomimetic Vesicles

open access: yesAdvanced Materials, EarlyView.
Artificial extracellular vesicles, derived from cell membranes, are manufactured using a multiphysics‐integrated microfluidic platform that combines nanoknife membrane rupture, herringbone chaotic mixing, and acoustothermal modulation. This standardizable workflow enables the predictable control of vesicle formation and therapeutic loading, while ...
Timofei Solodko   +16 more
wiley   +1 more source

Yu Nu Compound Regulates Autophagy and Apoptosis Through mTOR in vivo and vitro

open access: yesDiabetes, Metabolic Syndrome and Obesity, 2020
Caigu He,1 Guang Liu,1 Shuting Zhuang,2 Jialin Zhang,2 Yangtao Chen,1 Hetian Li,1 Zhengping Huang,1 Yanfang Zheng3 1Department of Histology and Embryology, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, People’s Republic ...
He C   +7 more
doaj  

Supplementary Figure 7 from Akt Inhibitors MK-2206 and Nelfinavir Overcome mTOR Inhibitor Resistance in Diffuse Large B-cell Lymphoma [PDF]

open access: gold, 2023
Adam M. Petrich   +10 more
openalex   +1 more source

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

open access: yesAdvanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li   +19 more
wiley   +1 more source

Tumor-stroma interactions influence the response to PI3K targeted agents in preclinical models of colorectal cancer (CRC) [PDF]

open access: yes, 2019
Introduction: One of the main obstacle to the successful development of therapeutic strategies remains the identification of biomarker underlying drug resistance. Recently, investigators have become more aware the role of the tumor microenvironment (TME)
Bazzichetto, Chiara
core  

Piezoelectric Stimulation of Neural Cells: Exploring the Synergistic Potential of Hybrid Scaffolds for Enhanced Regeneration

open access: yesAdvanced Materials Interfaces, EarlyView.
Hybrid piezoelectric scaffolds offer a promising route for Central Nervous System regeneration by combining structural and electrical cues to support neural stem cell growth. This review highlights their potential to overcome current challenges in neural tissue engineering by exploring porous hybrid materials, their biological interactions, and ...
Heather F. Titterton   +2 more
wiley   +1 more source

A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus [PDF]

open access: yes, 2002
Many forms of long-lasting behavioral and synaptic plasticity require the synthesis of new proteins. For example, long-term potentiation (LTIP) that endures for more than an hour requires both transcription and translation.
Gingras, Anne-Claude   +5 more
core  

Multiomics Analyses Reveal an Essential Role of Tryptophan in Treatment of csDMARDs in Rheumatoid Arthritis

open access: yesAdvanced Science, EarlyView.
Rheumatoid arthritis is a disease characterized by joint inflammation. Approximately 50% of patients show insufficient response to traditional synthetic disease‐modifying antirheumatic drugs. This study aims to elucidate differential molecular profiles of the mechanisms underlying drug responses through multi‐omics strategy.
Congcong Jian   +26 more
wiley   +1 more source

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