Results 161 to 170 of about 266,976 (313)

Inhibition of mTOR improves the impairment of acidification in autophagic vesicles caused by hepatic steatosis [PDF]

, 2015
Eisuke Nakadera, Shunhei Yamashina, Kousuke Izumi, Yoshihiro Inami, Toshifumi Sato, Hirofumi Fukushima, Kazuyoshi Kon, Kenichi Ikejima, Takashi Ueno, Sumio Watanabe   +9 more
openalex   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Effect of Dietary Taurine on the Innate Immune Responses, Digestive Function, and mTOR Signaling in Coho Salmon (<i>Oncorhynchus kisutch</i>). [PDF]

Aquac Nutr
Bian L, Wang Y, Zhang X, Zhang M, Liu D.
europepmc   +1 more source

Resident-Memory CD8 T Cells and mTOR: Generation, Protection, and Clinical Importance [PDF]

, 2015
Ryan Sowell, Amanda L. Marzo
openalex   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Targeting mTOR: up-to-date mTOR inhibitors

Biorganic and Medicinal Chemistry Reports, 2019
Banu Kilic, Meryem Temiz-Resitoglu, Seyhan Sahan Firat   +2 more
openaire   +1 more source

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source

Targeting accumulated apolipoprotein J in renal tubules halts the mTOR-TFEB interaction and relieves diabetic kidney disease [PDF]

Hung-Yu Sun, Shuangdi Duan, Nong Qin, Jiayi Pi, Pei Sun, C B Huang, Hsin‐Tzu Wang, Mei-Chi Huang, Sin-Tian Wang, Wen‐Chun Liu, Chi-Li Chi, Lamei Liu, Xing‐Yi Ge, Ye Qiu, Liyang Shi, Qiang Gao, Junfeng Shi, Shuen‐Ru Yang   +17 more
openalex   +1 more source

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source

mTOR pathway mediates the endoplasmic reticulum stress -apoptosis of CD4+ T cell through inhibiting autophagy flux in sepsis. [PDF]

Inflamm Res
Lei X, Zhao G, Xie Y, Cui N.
europepmc   +1 more source