Results 271 to 280 of about 209,258 (305)
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2008
Publisher Summary The mammalian target of rapamycin (mTOR) is the founding member of a family of unconventional high molecular weight serine/threonine protein kinases termed “phosphoinositide-3-kinase (PI3K)-related kinases (PIKKs).” Molecular and biochemical characterization of mTOR uncovered an important signaling network that regulates fundamental
Jeroen Verheijen, Ker Yu, Arie Zask
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Publisher Summary The mammalian target of rapamycin (mTOR) is the founding member of a family of unconventional high molecular weight serine/threonine protein kinases termed “phosphoinositide-3-kinase (PI3K)-related kinases (PIKKs).” Molecular and biochemical characterization of mTOR uncovered an important signaling network that regulates fundamental
Jeroen Verheijen, Ker Yu, Arie Zask
openaire +1 more source
Mammalian target of rapamycin (mTOR) inhibitors
Current Oncology Reports, 2004Current efforts in anticancer drug development are targeting key factors in cell-cycle regulation. Mammalian target of rapamycin (mTOR) is one such protein kinase that facilitates cell growth by stimulating the cell to traverse the G1 to S phase of the cell cycle.
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mTOR Pathway and mTOR Inhibitors in Cancer Therapy
20101. N. Kubica and J. Blenis "mTORC1: A signaling integration node involved in cell growth" 2. Z. Feng and A.J. Levine "The Regulation of the IGF-1/mTOR Pathway by the p53 Tumor Suppressor Gene Functions" 3. H. Mead, M. Zeremski and M. Guba "mTOR Signaling in Angiogenesis" 4. J. Brugaroles "mTOR signaling and hypoxia" 5. D. Akhavan and P.S. Mischel "mTOR
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mTOR at the nexus of nutrition, growth, ageing and disease
Nature Reviews Molecular Cell Biology, 2020Grace Y Liu, David M Sabatini
exaly