Results 61 to 70 of about 21,992 (209)

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

open access: yesAdvanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong   +20 more
wiley   +1 more source

Heritability of sow longevity and lifetime prolificacy in Finnish Yorkshire and Landrace pigs

open access: yesAgricultural and Food Science, 2013
The objective of this study was to estimate genetic parameters for longevity traits in Finnish pig populations. Analyzed traits were length of productive herd life (LPL), total number of parities (TNP), total number of piglets born (TNB), total number ...
Marja-Liisa Sevón-Aimonen, Pekka Uimari
doaj  

Genetic and environmental effects affecting the variation in birth date and birth weight of reindeer calves

open access: yesRangifer, 2013
The factors causing variation in birth date and birth weight were analysed from the data from an experimental reindeer herd consisting of 1136 calves with parental information. The traits had coefficient of variation of 37 and 14%, respectively.
Kirsi Muuttoranta   +5 more
doaj   +1 more source

A Hydrogen Sulfide–Releasing Dynamic Hydrogel Modulates Coordinated Neurovascular, Immune, and Angiogenic Responses for Scar‐Suppressed Diabetic Wound Repair

open access: yesAdvanced Science, EarlyView.
ROS‐Responsive H2S Hydrogel (HAPPF) Coordinated Regeneration for High‐Quality Diabetic Wound Repair.A self‐regulating dynamic hydrogel is developed to deliver a fluorogenic H2S donor in response to excessive ROS. Released H2S acts as a master regulator to resolve chronic inflammation (M2 polarization), restore VEGF‐driven angiogenesis, and rebalance ...
Xuyang Ning   +7 more
wiley   +1 more source

Potential and limitations of phosphate retention media in water protection: A process-based review of laboratory and field-scale tests

open access: yesAgricultural and Food Science, 2012
The application of phosphorus (P)-sorbing materials offers a possible solution for treating municipal wastewater and agricultural runoff. In this paper we discuss P retention and release mechanisms, and review studies on the P retention of different ...
Aleksandar Klimeski   +3 more
doaj  

PRMT5‐Dependent Stabilization of VPS34 Orchestrates Copper Trafficking to Shield Cancer Cells from Cuproptosis and Radiotherapy

open access: yesAdvanced Science, EarlyView.
Radioresistance arises partly from tumor cells evading cuproptosis via unknown defenses. This study reveals that the PRMT5‐VPS34 axis acts as a radiation‐activated anticuproptotic mechanism: PRMT5 methylates VPS34 at Arg174, recruiting USP10 to remove K48‐linked ubiquitination and prevent degradation.
Wei Chen   +17 more
wiley   +1 more source

Risk, Information, and Trust in the Food Chain: Factors Explaining Consumer Willingness to Pay

open access: yesInternational Journal on Food System Dynamics, 2011
This paper analysed factors contributing to consumers’ willingness to pay (WTP) for increased quality information. The empirical scope of the study was restricted to beef, because the beef labelling system enables reliable tracing of quality ...
Terhi Latvala
doaj  

Self‐Sustaining Lactate Depletion Nanoplatform Remodels Tumor Microenvironment and Augments Synergistic Photodynamic/Photothermal/Chemodynamic/Starvation Therapy for Eradication of Colon Cancer

open access: yesAdvanced Science, EarlyView.
The HILA nanoplatform integrates HMnO2, LOX, and ICG to orchestrate multimodal therapy (starvation, chemodynamic, photodynamic, and photothermal) for achieving efficient colon cancer eradication. The established HMnO2‐LOX catalytic cycle continuously consumes lactate, acidifys microenvironment, relieves hypoxia, and generats reactive oxygen species ...
Yu‐E. Wang   +11 more
wiley   +1 more source

Effect of Fish Meal Level on Growth, Food Digestibility and Fur Properties of Farmed Mink (Mustela vison)

open access: yesAnimal Production: Indonesian Journal of Animal Production, 2012
. Our study sought to determine the effects of normal vs high fish meal levels in the diet on the growing-furring process and apparent food digestibility of farmed male mink (Mustela vison).
HT Korhonen, P Niemelä
doaj  

NIR‐II Light‐Triggered Electron Flow Initiates Cuproptosis‐Centered Thermoelectric‐Immunotherapy for Breast Cancer

open access: yesAdvanced Science, EarlyView.
A NIR‐II light‐activatable thermoelectric nanoreactor converts surface‐bound Cu2+ into bioactive Cu+ via directed electron flow. This spatiotemporally controlled reduction triggers potent cuproptosis and immunogenic cell death, eradicating primary tumors and, together with aPD‐1 therapy, suppressing metastases while establishing durable immune memory ...
Boyu Yuan   +10 more
wiley   +1 more source

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