Results 51 to 60 of about 21,992 (209)

SNeP: a tool to estimate trends in recent effective population size trajectories using genome-wide SNP data.

Frontiers in Genetics, 2015
Effective population size (Ne) is a key population genetic parameter that describes the amount of genetic drift in a population. Estimating Ne has been subject to much research over the last 80 years.
Mario eBarbato, Pablo Andrés Orozco-terWengel, Miika eTapio, Michael William Bruford   +3 more
doaj   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Effect of breed on production, carcass traits and meat quality of Aberdeen Angus, Limousin and Aberdeen Angus×Limousin bulls offered a grass silage-grain-based diet

Agricultural and Food Science, 2012
The objective of the experiment was to study the performance, carcass traits and meat quality of purebred Aberdeen Angus (Ab) and Limousin (Li) bulls and Ab×Li crossbred bulls offered grass silage-grain-based rations and raised to heavy carcass weights ...
Maiju Pesonen, Markku Honkavaara, Arto Kalevi Huuskonen   +2 more
doaj  

Evaluation of protein supplementation for growing cattle fed grass silage-based diets: a meta-analysis

Animal, 2014
The objective of this meta-analysis was to develop empirical equations predicting growth responses of growing cattle to protein intake. Overall, the data set comprised 199 diets in 80 studies.
A. Huuskonen, P. Huhtanen, E. Joki-Tokola   +2 more
doaj   +1 more source

Engineered Au@CeO2 Hybrid Nanoparticles With Microenvironment Dependent Self‐Adjustability for Integration of Tumor‐Specific Photothermal‐Chemodynamic Therapy and Inflammation Prevention

Advanced Science, EarlyView.
An intelligent Au@CeO2 Hybrid Nanoparticles (ACEF) with microenvironment‐dependent self‐adjustability was engineered to not only perform efficient and tumor‐specific photothermal‐chemodynamic therapy for precise tumor elimination, but also serve as a ROS scavenger in healthy tissues around the tumor to avoid the unexpected oxidative damage and ...
Wenyun Mu, Wenjuan Tang, Handan Zhang, Jie Liu, Jiaqi Zhang, Yu Yao, Xiao Fu, Xin Chen, Yanmin Zhang   +8 more
wiley   +1 more source

Use of the “Ru‐1O2‐Hydrazide” System Catalyzed by Metallic Ruthenium Complexes to Decipher the Interaction Between Microbes and Host Cancer Cells

Advanced Science, EarlyView.
ABSTRACT The dynamic interplay between bacteria and host cancer cells plays a critical role in tumor microenvironment modulation, bacterial pathogenesis, and potential oncotherapy applications. However, traditional methods often fail to capture transient or spatially restricted molecular interactions at the bacteria‐cancer cell interface.
Amin Sun, Kaihong Wang, Haifu Sun, Kemei Tao, Xiang Li, Xiuhua Zhao, Shuang Qiu   +6 more
wiley   +1 more source

ZER1 Restrains Pressure Overload‐Induced Cardiac Remodeling by Targeting DVL2 for Gly/N‐Degron‐Dependent Degradation

Advanced Science, EarlyView.
Pressure overload suppresses cardiomyocyte ZER1, weakening CRL2Zer1‐mediated DVL2 degradation and allowing DVL2 accumulation. Elevated DVL2 activates CaMKII‐HDAC4‐MEF2C signaling, drives fetal gene reactivation, and promotes pathological remodeling.
Mingchao Jiang, Zhehao Lin, Lu Chen, Ying Ni, Jun Zhou, Wenjuan Zhang, Huilin Wang, Peifeng Ying, Xiu Lu, Kai Wang, Qingran Kong, Naxin Xu, Dingsheng Zhao, Jianwei Li, Guohui Zhong, Xingchen Meng, Sarkawt Hamad, Junmeng Zheng, Yuan Fu, Rongjiang Qin, Xuran Chu, Shangxuan Li, Youyou Li, Yili Wu, Yi Wang, Weihong Song, Yingxian Li, Shukuan Ling   +27 more
wiley   +1 more source

A Pathology‐Instructed Theranostic Platform with Mechanoadaptive and ROS‐Powered Nanobreathing Functions for Precision Myocardial Repair

Advanced Science, EarlyView.
We developed a pH responsive theranostic serum albumin hydrogel named BST, functionalized with MRI and CT probes and loaded with mitochondria targeted CAT‐SOD nanogels, that rapidly self repairs and mechanically stabilizes the infarcted myocardium, releases therapeutic nanogels and albumin under hypoxia induced acidosis to clear mitochondrial ROS ...
Zheng Luo, Cui Yang, Liuzhou Mao, Panqin Ma, Chiyu Jia, Karen Yuanting Tang, Xian Jun Loh, Yun‐Long Wu   +7 more
wiley   +1 more source

A comparison of purebred Holstein-Friesian and Holstein-Friesian × beef breed bulls for beef production and carcass traits

Agricultural and Food Science, 2013
The objective of this study was to determine beef production traits of purebred Holstein-Friesian (Hol) and Hol×beef breed crossbred bulls. The data collected from slaughterhouses included observations of 87323 purebred Hol, 783 Hol×Aberdeen angus (Hol ...
Arto Kalevi Huuskonen, Maiju Pesonen, Hilkka Kämäräinen, Risto Kauppinen   +3 more
doaj  

Genetic variation in meat production related traits in reindeer (Rangifer t. tarandus)

Rangifer, 2014
In reindeer husbandry, animal breeding could offer tools for improving productivity by selection. The traits affecting meat production efficiency are primarily related to calf growth and survival, and to dam’s longevity and lifetime ability to raise ...
Kirsi Muuttoranta, Øystein Holand, Knut H. Røed, Miika Tapio, Mauri Nieminen, Asko Mäki-Tanila   +5 more
doaj   +1 more source