Results 51 to 60 of about 143,397 (262)

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Strategic objectives and development plans of beginning farmers

Agricultural and Food Science, 2012
Taking over the management and ownership of a farm contributes positively to farm growth but little is known about how farmers succeed after the starting phase.
Leena Rantamäki-Lahtinen, Minna Katriina Väre   +1 more
doaj  

Profitability bookkeeping in the reindeer husbandry

Rangifer, 2007
See extended abstract in Full ...
Arto Latukka, Olli Rantala, Jukka Tauriainen   +2 more
doaj   +1 more source

Ohrapellon tähtöset

, 2013
Blogikirjoitus MTT Elo ...
Jalli, Marja
core  

Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis

Advanced Science, EarlyView.
The Gela/decitabine/La2(CO3)3 colloidal (GDLC) hydrogel developed here could reverse the epigenetic silencing of the GSDME gene by the synergistic interaction between DAC and La3+, while concurrently activating caspase‐3, thus facilitating pyroptosis induction under the tumor microenvironment.
Yang Hong, Haitao Wu, Weitao Wang, Xuan Zhang, Qian Chen, Yaoyu Hu, Zhengbao Zha   +6 more
wiley   +1 more source

Climate change adaptation in arable land use, and impact on nitrogen load at catchment scale in northern agriculture

Agricultural and Food Science, 2013
Prolongation of the growing season due to a warming climate could represent new opportunities for northern agriculture. Climatic and biotic constraints may challenge future crop production.
Katri Rankinen, Pirjo Peltonen-Sainio, Kirsti Granlund, Hannu Ojanen, Mikko Laapas, Kaija Hakala, Kalle Sippel, Juha Helenius, Martin Forsius   +8 more
doaj  

Laadukasta keräkaalia myöhään syksyllä

, 1997
vokMyynti: MTT puutarhatuotannon tutkimuslaitos. Hinta: 5 raporttia yht.
Suojala, Terhi
core  

Magneto‐NIR‐II‐Programmed Cascade Nanozymes Unlocking Blood–Brain Barrier Translocation and Autophagic Resistance in Glioblastoma

Advanced Science, EarlyView.
Magneto‐NIR‐II‐programmed NFSH nanozymes integrate magnetic blood–brain barrier (BBB) translocation, CD44 targeting, multimodal imaging, and cascade catalytic therapy for glioblastoma. Alternating magnetic fields and NIR‐II irradiation amplify ferroptosis, release H2S, suppress autophagic and mitophagic repair, and reshape the immune microenvironment ...
Ruocan Liu, Yundi Wu, Shuai Zhang, Hongjuan Zhao, Jiping Zheng, Shiyang Shao, Jianqiang Chen, Xilong Wu   +7 more
wiley   +1 more source

Protein crop production at the northern margin of farming: to boost or not to boost

Agricultural and Food Science, 2012
Global changes in food demand resulting from population growth and more meat-intensive diets require an increase in global protein crop production, not least as climate change and increasing scarcity of fresh water could restrict future production.
Pirjo Peltonen-Sainio, Jarkko K. Niemi
doaj  

SNeP: a tool to estimate trends in recent effective population size trajectories using genome-wide SNP data.

Frontiers in Genetics, 2015
Effective population size (Ne) is a key population genetic parameter that describes the amount of genetic drift in a population. Estimating Ne has been subject to much research over the last 80 years.
Mario eBarbato, Pablo Andrés Orozco-terWengel, Miika eTapio, Michael William Bruford   +3 more
doaj   +1 more source