Results 191 to 200 of about 330,112 (309)

Rational Design of a Synthetic Galliphore for the Diagnostic Nuclear Imaging and Treatment of Bacterial Infections

Angewandte Chemie, EarlyView.
KO‐NH2 is a synthetic metallophore that preferentially binds Ga3+ over Fe3+ and is recognized by bacterial transporters. Photocrosslinking identifies CirA and Fiu as key uptake proteins in E. coli. KO‐NH2 enables targeted imaging and treatment of E. coli soft tissue infections.
Phuong Nguyen Tran, Axia Marlin, Edith K. Amason, Marie Huynh, Hannah Carlisle, Eszter Boros   +5 more
wiley   +2 more sources

Mitochondrial transplantation for delirium superimposed on dementia: from pathogenic mechanisms to clinical translation challenges. [PDF]

Front Aging Neurosci
Hu W, He Y, Peng Q, Sun F.
europepmc   +1 more source

Created Ex Nihilo: A Near‐Infrared Afterglow Luminescent Framework of Imidazole Derivatives for Bioimaging

Angewandte Chemie, EarlyView.
A series of Ir(III) complexes (Ir‐1‐Ir‐4) based on imidazole derivatives provide a new afterglow luminescence mechanism. The work expands the range of afterglow luminescence frameworks to overcome: (i) a lack of new afterglow scaffolds; (ii) the dependence on initial external light activation; and (iii) aggregation‐caused quenching.
Zihan Wu, Liping Zhang, Ziwei Wang, Yachao Wang, Gelin Xu, Feng Chi, Dongxia Zhu, Martin R. Bryce, Ben Zhong Tang, Lijie Ren   +9 more
wiley   +2 more sources

Synthese und aktivitätsbasierte Proteinprofilierung identifizieren die Aldo‐Keto‐Reduktase 1C3 als Zielprotein der Myxoglucamide

Angewandte Chemie, EarlyView.
Myxoglucamid A – ein neuartiges, aus Myxobakterien isoliertes Glykolipopeptid – wurde erstmals totalsynthetisch hergestellt. Mittels aktivitätsbasierter Proteinprofilierung (ABPP) wurde die Aldo‐Keto‐Reduktase 1C3 (AKR1C3) als primäres Zielprotein in menschlichen Zellen identifiziert.
Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

Parametric color-coding-derived microvascular transit time may predict infarction and reveals microcirculatory benefits of Tenecteplase in acute ischemic stroke. [PDF]

Front Neurol
Singer L, Becker J, Sprügel M, Keller N, Sekita A, Sembill J, Lücking H, Mohamed SA, Schwab S, Gerner ST, Doerfler A, Engelhorn T.   +11 more
europepmc   +1 more source

TiZrHf-Based B2-B19'/B19-High Entropy Shape Memory Alloys: A Review and Recent Advances. [PDF]

Materials (Basel)
Yamabe-Mitarai Y.
europepmc   +1 more source

Preclinical Evaluation of Labetalol for Cutaneous Melanoma Drug Repurposing: Cytotoxic Activity in A375 Cells and Mitochondria-Associated Apoptotic Signaling. [PDF]

Medicina (Kaunas)
Dahma R, Moacă EA, Predescu IA, Dragomir AC, Iftode OA, Iurciuc S, Haj Ali D, Macaşoi I, Sala-Cîrtog M, Crintea IN, Tănase AD, Dinuţi M.   +11 more
europepmc   +1 more source

Long Non-Coding Ribonucleic Acid Taurine Up-Regulated Gene 1 Accelerates Ventricular Septal Defect Formation in Children. [PDF]

Braz J Cardiovasc Surg
Zhong X, Jin W, He L, Liang J.
europepmc   +1 more source

Photoinduzierte Freisetzung maskierter Iridium(III)‐Komplexe für die kombinierte photodynamische und photoaktivierte Chemotherapie

Angewandte Chemie, EarlyView.
Lichtaktivierbare Iridium(III)‐Prodrugs zeigen, wie die Koordination von Chalkogenen die photoinduzierte therapeutische Aktivität steuert. Bei Bestrahlung mit sichtbarem Licht laufen an den schwefel‐ bzw. selenhaltigen Liganden unterschiedliche, sauerstoffabhängige Photoreaktionen ab.
Victoria V. L. Müller, Dominik Moreth, Irene Regeni, Lan Wang, Sylvestre Bonnet, Ulrich Schatzschneider   +5 more
wiley   +1 more source

CT Perfusion in lacunar stroke: a powerful tool to enhance lacunar stroke detection and prediction of patients' outcome. [PDF]

Neurol Sci
Vincis E, Ricci E, Furlanis G, Prandin G, Palacino F, Mancinelli L, Quagliotto M, Malesani M, Farina G, Caruso P, Ukmar M, Ajčević M, Naccarato M, Manganotti P.   +13 more
europepmc   +1 more source