Results 141 to 150 of about 209,250 (266)

Biophysical Characterization and Proteomic Analysis of Small Extracellular Vesicles Derived From Different Neural Cell Lines

open access: yesAdvanced NanoBiomed Research, EarlyView.
This study systematically compares small extracellular vesicles (sEVs) derived from four neural cell lines, revealing how cellular origin shapes vesicle biophysical properties and proteomic cargo. Distinct, lineage‐specific signatures linked to neuronal, astrocytic, and microglial functions are identified, highlighting the importance of cell source ...
Muhammad Waqas Salim   +4 more
wiley   +1 more source

Biomimetic Nanoparticle Delivering Colchicine to Target Endothelial Inflammation for Atherosclerosis Treatment

open access: yesAdvanced NanoBiomed Research, EarlyView.
Platelet membrane‐coated layered double hydroxide nanoparticles were engineered to target inflamed endothelium at early‐stage atherosclerosis and enhance therapeutic efficacy. The biomimetic platform improves stability, immune escape, and inflamed vascular cell targeting, resulting in reduced oxidative stress and downregulated adhesion molecules.
Xiuwen Zhang   +4 more
wiley   +1 more source

Metabolische Untersuchungen lebender Zellen im Minutentakt, ermöglicht durch schnelle Parawasserstoff‐basierte Hyperpolarisation

open access: yesAngewandte Chemie, EarlyView.
Die schnelle Parawasserstoff‐Hyperpolarisation in Kombination mit einfacher Verdünnung ermöglicht die Zufuhr von hyperpolarisiertem, biokompatiblen Pyruvats zu immobilisierten lebenden Zellen innerhalb von ≈1 min. Wiederholte Substratinjektionen offenbaren frequenzabhängige metabolische Dynamiken und eröffnen damit eine neue zeitliche Dimension für ...
Philipp R. Groß   +17 more
wiley   +1 more source

Minute‐Scale Repeated Metabolic Probing of Living Cells Enabled by Rapid Parahydrogen‐Based Hyperpolarization

open access: yesAngewandte Chemie International Edition, EarlyView.
Rapid parahydrogen hyperpolarization combined with simple dilution enables biocompatible delivery of hyperpolarized pyruvate to immobilized living cells within ≈1 min. Repeated substrate injections reveal frequency‐dependent metabolic dynamics, introducing a new temporal dimension for hyperpolarized NMR studies of cellular metabolism and enabling rapid
Philipp R. Groß   +17 more
wiley   +1 more source

Synthesis, Characterization, Antioxidant Evaluation, Cytotoxicity Studies, and Molecular Docking of Novel Sulfonamide Derivatives. [PDF]

open access: yesJ Biochem Mol Toxicol
Bouraoui O   +8 more
europepmc   +1 more source

Machine Learning‐Enabled Prediction of pH‐Responsive Curcumin Release From Self‐Assembled Nanomicelles

open access: yesJournal of Applied Polymer Science, EarlyView.
Curcumin encapsulation in nanomicelles coupled with a machine learning–guided model for predicting its release profile. ABSTRACT This work, leveraging machine‐learning algorithms, focuses on the design and in vitro evaluation of oil‐in‐water surfactant‐based nanomicelles as a novel curcumin formulation with comparable cytotoxic effects against MCF‐7 ...
Abbas Rahdar   +3 more
wiley   +1 more source

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