Results 141 to 150 of about 330,112 (309)

Policy change and learning: Implementing EU environmental policies affecting agriculture [PDF]

open access: yes, 2009
This thesis aims to show whether and how the implementation of the EU environmental policy could be improved through policy learning. The results are based on two case studies: the development of agri-environmental policy in Finland and the ...
Kröger, Laura
core  

Kruunutillin viljelykokemuksia vuodelta 1997

open access: yes, 2000
Seminaarin järjestäjät: MTT, Luonnonvarojen tutkimuslaitos, Ekologisen tuotannon tutkimusasema ja Agropolis ...
Keskitalo, Marjo
core  

MTT Horticulture supports the horticultural industry in Finland

open access: yes, 2007
vokMyynti MTT Tietopalvelut 31600 ...
Tahvonen, Risto
core  

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

open access: yesAdvanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai   +7 more
wiley   +1 more source

Carbohydrate‐Mediated Cellular Uptake of Boronic Acid Hybrids In Cellulo and Insulin‐Deficient Zebrafish: Live Imaging and Application of Multiphoton FLIM

open access: yesAdvanced Science, EarlyView.
Boronic acid‐based fluorescent hybrids have been used as part of a versatile platform for real‐time metabolic bioimaging across cellular and organismal scales. Including glucose‐responsive imaging in living cells and in an insulin‐deficient vertebrate model, this work opens new opportunities for the development of precision diagnostics, metabolic ...
Haobo Ge   +13 more
wiley   +1 more source

MTT ja turkistuottajat yhteistyössä

open access: yes, 2010
Uudet tuulet puhalsivat Maa- ja elintarviketalouden tutkimuskeskuksen (MTT) Kannuksen turkistutkimusasemalla kolme vuotta sitten. Oli aika aloittaa viisivuotinen ruokintatutkimusprojekti, jonka rahoitukseen osallistuvat MTT:n lisäksi Helven Säätiö ja ...
Nenonen, Nita
core  

Carrier‐Free Stimulus‐Responsive Theranostic Nanoprodrug Enabling GSH‐Consumption‐Promoted Chemo‐Photodynamic Cancer Therapy

open access: yesAdvanced Science, EarlyView.
Leveraging the critical role of glutathione (GSH) in mediating drug resistance and scavenging reactive oxygen species (ROS) in cancer cells, a carrier‐free GSH‐consuming theranostic nanoprodrug, consisting of a BODIPY photosensitizer and the chemotherapeutic drug paclitaxel linked through a GSH‐consuming drug linker, is developed to deeply explore the ...
Hansheng Huang, Binglin Sui
wiley   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

open access: yesAdvanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai   +4 more
wiley   +1 more source

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren   +11 more
wiley   +1 more source

Marjoram Extract Modulates Ion Currents, Intracellular Calcium Signaling, and MTT-Reducing Activity in Bovine Chromaffin Cells and Rat Cortical Neurons. [PDF]

open access: yesPharmaceuticals (Basel)
de Pascual R   +10 more
europepmc   +1 more source

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