Advanced Science, EarlyView.A DNA‐functionalized biohybrid hydrogel is developed by integrating Cu‐mediated nucleic acid microflowers into a thermoresponsive matrix, enabling electrothermally triggered, on‐demand payload release. The platform offers spatiotemporally controllable therapeutic delivery with promising applications in precision oncology, neural regulation, and chronic
Mengqiu Sun +8 more
wiley +1 more source
Advanced Science, EarlyView.We report a lipid‐droplet‐engineered, gallium‐loaded sonodynamic therapeutic platform (LDTG) incorporated into a bilayer microneedle (MN) patch co‐delivering all‐trans retinoic acid (ATRA), termed LDTG A‐MNs, for synergistic antibacterial therapy and accelerated wound repair.
Peng Jiang +9 more
wiley +1 more source
Ligand substituent effect on the cytotoxicity activity of two new copper(ii) complexes bearing 8-hydroxyquinoline derivatives: validated by MTT assay and apoptosis in MCF-7 cancer cell line (human breast cancer). [PDF]
RSC Adv, 2021 Ali A +9 more
europepmc +1 more source
Advanced Science, EarlyView.A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che +9 more
wiley +1 more source
The Far Side of Carboranes: Anticancer Active Monocations and Ambiently Stable Dications
Angewandte Chemie, EarlyView.This work describes the synthesis of bench‐stable dicationic carboranes. Their enhanced electrophilicity is documented by opening the clusters with weak nucleophiles or dihydrogen. The surprising stability of positively charged carboranes in water enabled a study of their in vitro antiproliferative activity, which surpassed the effects of doxorubicin ...
Vlastimil Němec +10 more
wiley +2 more sources
From in-silico QSAR modeling to in-vitro MTT assay: experimental validation of novel uPAR leads for triple-negative breast cancer (TNBC) and skin cancer. [PDF]
Sci RepBadukle H +8 more
europepmc +1 more source
Acoustic Impedance‐Tailored High‐Performance Ultrasound‐Driven Triboelectric Nanogenerators
Advanced Energy Materials, EarlyView.An acoustic impedance–mismatched triboelectric nanogenerator is presented for efficient ultrasound energy harvesting in implantable medical devices. Concave and convex membrane patterning induces controlled acoustic impedance mismatch, which boosts output by ∼200% and ensures stable operation over 100 million cycles and six weeks in vivo, highlighting ...
Young‐Jun Kim +8 more
wiley +1 more source
Two-Step Air/Water Oxidation Process for the Long-Lasting Photoluminescence and Biological Viability (MTT Assay) of Porous Silicon Particles. [PDF]
J XenobiotCastillo Calvente C +7 more
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.Chronic alcohol exposure disrupts intestinal barrier integrity, resulting in a leaky gut and enhanced translocation of lipopolysaccharide (LPS) and microbial products into the systemic circulation. Alcohol‐induced endotoxemia drives exaggerated pro‐inflammatory responses, mitochondrial damage, and activation of the cGAS–STING pathway, particularly in ...
Thansita Bhunyakarnjanarat +5 more
wiley +1 more source
Evaluation of Cytotoxicity of Premixed Triple Antibiotic Paste on Stem Cells of Apical Papilla Using MTT Assay: An <i>In Vitro</i> Study. [PDF]
Int J Clin Pediatr DentSaravanan E, Ravindran V.
europepmc +1 more source