Results 81 to 90 of about 2,250,294 (367)

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

MTT Assay v1

The CyQUANT MTT Cell Viability Assay utilizes the well-established and widely used MTT reagent to determine mammalian cell viability. The redox potential in active mammalian cells reduces MTT to a strongly pigmented formazan product. After solubilization, the absorbance of the formazan can be measured with a microplate absorbance reader.
Songyot Anuchapreeda, Siriporn Okonogi, Mathurada Sasarom   +2 more
openaire   +2 more sources

Analysis of Mycotoxins and Cytotoxicity of Airborne Molds Isolated from the Zoological Garden—Screening Research

Pathogens
Objective: The objective of this paper was to assess the airborne mold contamination, secondary metabolite profiles, and cytotoxicity of the dominant fungal species isolated from the air in selected rooms at a Zoological Garden.
Kinga Plewa-Tutaj, Magdalena Twarużek, Robert Kosicki, Ewelina Soszczyńska   +3 more
doaj   +1 more source

Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis. [PDF]

, 2018
Understanding the molecular signaling in programmed cell death is vital to a practical understanding of inflammation and immune cell function. Here we identify a previously unrecognized mechanism that functions to downregulate the necrosome, a central ...
A Degterev, A Degterev, A Kaczmarek, A Polykratis, B Shutinoski, C Fearns, CP Dillon, D Ofengeim, DE Christofferson, DM Monack, DM Moquin, DR Green, EW Harhaj, F Ginhoux, G Dougan, H Sakamoto, I Jaco, J Hitomi, JW Upton, K Newton, KE Lawlor, L Duprez, L Eckmann, L Galluzzi, LA O’Neill, M Belosevic, M Pasparakis, MA Brennan, MJ Bertrand, N Arpaia, N Bidere, N Festjens, N Robinson, N Shembade, N Takahashi, N Vanlangenakker, N. Peltzer, P Mandal, P Vandenabeele, P Vandenabeele, R Bellamy, R Patel, RE Voll, S Akira, S He, S He, S Malladi, S McComb, S McComb, S McComb, S McComb, SB Berger, SC Sun, SP Salcedo, ST Beug, T McQuade, T Vanden Berghe, T Xie, TH Chuang, W Declercq, W Reiley, WD Cook, WJ Kaiser, WW Reiley, XN Wu, Y Dondelinger, YS Cho, Z Cai   +67 more
core   +2 more sources

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Spectrochemical characterization of Vero cell line against PPR virus infection

Journal of Advanced Biotechnology and Experimental Therapeutics, 2019
An in vitro virus infectivity assay based on the newly introduced spectrochemical method was performed using Peste des Petits Ruminants (PPR) virus infected Vero cell line as a model infection.
Md. Mizanur Rahman, Kumar Jyotirmoy Roy, Mst. Khudishta Aktar, Md. Rafiqul Islam, Md.Abdul Kafi   +4 more
doaj   +1 more source

Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner [PDF]

, 2016
Bladder cancer (BC) is a common urologic tumor characterized by high risk of recurrence and mortality. Capsaicin (CPS), used as an intravesical drug for overactive bladder, was demonstrated to induce cell death in different cancer cells including BC ...
Amantini, C, CARDINALI, CLAUDIO, GISMONDI, Angela, MORELLI, MARIA BEATRICE, Nabissi, M, Santoni, G., Santoni, M   +6 more
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Cytotoxic Potential of Centaurea bruguierana ssp. belangerana: The MTT Assay

Acta Medica Iranica, 2016
The genus Centaurea with an extensive background in Iranian traditional medicine represents more than 70 species in Iran that some of them are endemic to Iran. A variety of secondary metabolites has been isolated from this genus thus far.
Seyed Nasser Ostad, Afsaneh Rajabi, Rahim Khademi, Fatemeh Farjadmand, Mahdieh Eftekhari, Abbas Hadjiakhoondi, Mahnaz Khanavi   +6 more
doaj  

Direct and indirect air particle cytotoxicity in human alveolar epithelial cells [PDF]

, 2014
Air particulate matter has been associated with adverse impact on the respiratory system leading to cytotoxic and proinflammatory effects. The biological mechanisms behind these associations may be initiated by inhaled small size particles, particle ...
Astort, Francisco, Maglione, Guillermo Alberto, Orona, Nadia Soledad, Saldiva, P. H. N., Tasat, Deborah Ruth, Yakisich, Juan Sebastian   +5 more
core   +1 more source