Results 151 to 160 of about 21,152 (196)

Muc1 Immunotherapy

Immunotherapy, 2010
The overexpression and aberrant glycosylation of MUC1 is associated with a wide variety of cancers, making it an ideal target for immunotherapeutic strategies. This review highlights the main avenues of research in this field, focusing on adenocarcinomas, from the preclinical to clinical; the problems and possible solutions associated with each ...
Beatson, Richard, Burchell, Joy, Taylor-Papadimitriou, Joyce   +2 more
openaire   +3 more sources

MUC1 expression in plasmacytoma

Leukemia Research, 2001
Plasmacytoma (Pm) is a plasma cell (PC) neoplasia consisting of PCs and some of them show progression to multiple myeloma. But there is no clear indicators predicting this progression. In this study, MUC1 expression was evaluated in Pm cases to determine the predictive value and was compared with histopathologic grade which is known to be a prognostic ...
Paydaş S., Şahin B., Gönlüşen G., Hazar B., Zorludemir S.   +4 more
openaire   +3 more sources

MUC1 and the Immunobiology of Cancer

Journal of Mammary Gland Biology and Neoplasia, 2002
The membrane epithelial mucin MUC1 is expressed at the luminal surface of most simple epithelial cells, but expression is greatly increased at lactation and in most breast carcinomas. The increase in level of expression of MUC1 in breast cancer is accompanied by changes in the profile of glycosyl transferases involved in the synthesis of the O-glycans ...
Taylor-Papadimitriou, J, Burchell, J M, Plunkett, T, Graham, R, Correa, I, Miles, D, Smith, M   +6 more
openaire   +3 more sources

MUC1, The Renaissance Molecule

Journal of Mammary Gland Biology and Neoplasia, 2001
MUC1 is a large, heavily glycosylated mucin expressed on the apical surfaces of most simple, secretory epithelia including the mammary gland, gastrointestinal, respiratory, urinary and reproductive tracts. Although MUC1 was thought to be an epithelial-specific protein, it is now known to be expressed on a variety of hematopoietic cells as well.
openaire   +2 more sources

MUC1 expression, splice variant and short form transcription (MUC1/Z, MUC1/Y) in prostate cell lines and tissue

BJU International, 2003
OBJECTIVE To detect the expression and transcription pattern of MUC1 in benign and malignant disease, and in two widely studied cell lines, and to investigate the glycosylation of MUC‐1 in bone metastasis of prostate cancer, as mucins have been implicated in the progression and behaviour of several cancers.
I C, Schut, P M, Waterfall, M, Ross, C, O'Sullivan, W R, Miller, F K, Habib, C W, Bayne   +6 more
openaire   +2 more sources

Expression of MUC1 in tubal pregnancy

Fertility and Sterility, 2008
The MUC1 mucin is normally expressed in the epithelium of the fallopian tube, and its expression on the epithelium of the tubes with ectopic pregnancies has not been studied. The mean (+/- SEM) histologic score for MUC1 was 1.4 +/- 0.2 in the luminal epithelium of tubes with ectopic pregnancies, and the histologic score for normal tubes was 2.8 +/- 0.2;
Ricardo Francalacci, Savaris, Luiz Carlos, da Silva, Gisele da Silva, Moraes, Maria Isabel Albano, Edelweiss   +3 more
openaire   +2 more sources

Running a MUC1

Nature Reviews Cancer, 2012
The UK press got carried away with a cancer story this week. It seems that a universal cancer vaccine is on its way, despite the fact that it has only been trialled in ten patients (with five more still to be recruited).
openaire   +1 more source

MUC1 in carcinoma-host interactions

Glycoconjugate Journal, 2000
Many carcinoma-associated markers are glycoconjugates whose expression undergoes temporal or spatial regulation. Mucin-1 (MUC1), discovered through monoclonal antibody technology, is a well-documented example of such a molecule and influences numerous pathophysiological behaviors, such as the invasion and metastasis of carcinoma cells.
K, Denda-Nagai, T, Irimura
openaire   +2 more sources

MUC1 in Endometriosis and Ovarian Cancer

Immunologic Research, 2006
Endometriosis is a chronic, debilitating disease, associated with pelvic pain and infertility. Recent epidemiological studies suggest that women with endometriosis are at increased risk for ovarian cancer. Although the causative factors for both endometriosis and ovarian cancer remain largely unknown, several similarities between the proposed etiology ...
Anda M, Vlad, Iulia, Diaconu, Kira R, Gantt   +2 more
openaire   +2 more sources

Transcriptional control of the expression of MUC1

Expert Review of Endocrinology & Metabolism, 2008
MUC1 is a multifunctional cell surface glycoprotein that modulates cell adhesion, protects mucosa from infection and enzymatic attack, lubricates cell surfaces, participates in multiple signal-transduction pathways and is overexpressed by many tumors. MUC1 levels change dynamically in various cellular contexts.
Daniel D, Carson, Neeraja, Dharmaraj, Peng, Wang   +2 more
openaire   +2 more sources