Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng +16 more
wiley +1 more source
Studies on the Mucilage from Rhodophyceae. (III)
T. MORI, Y. TUTIYA
openaire +5 more sources
Agro-morphological and phytochemical diversity among Alcea Kurdica populations using multivariate analyses. [PDF]
Tafreshi YM +4 more
europepmc +1 more source
Chemical short‐range order (CSRO) plays a central role in governing the behavior of multi‐principal element alloys. This perspective critically assesses computational and experimental approaches for quantifying, characterizing, and validating CSRO, emphasizing modeling–experiment cross‐validation pathways that enable more reliable interpretation of ...
Mohsen Asle Zaeem, Peter K. Liaw
wiley +1 more source
Correction: Improving electrocoagulation performance by adding environmentally friendly materials. [PDF]
Barakat MMM, Soliman MSS, Mubarak MF.
europepmc +1 more source
Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders
Antibody can be engineered into diverse lysosome‐targeting chimeras that convert target recognition into active degradation. By coupling antibody binding with recruited receptors, encoded domains, conjugated ligands, or nanoparticle scaffolds, these antibody‐associated targeted chimeras (AbTACs) platforms direct extracellular and membrane proteins ...
Kaige Chen, Quanyin Hu
wiley +1 more source
抄録
openaire
Nanocomposites of Opuntia ficus-indica mucilage-mediated selenium nanoparticles and nanochitosan as antidiabetic candidates in streptozocin-induced diabetic rats. [PDF]
El Rabey HA +6 more
europepmc +1 more source
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem +24 more
wiley +1 more source
Okra extract as a promising biopolymeric shield for robust <i>Bifidobacterium animalis</i> encapsulation and enhanced viability against processing and gastrointestinal stress. [PDF]
Chhe S +9 more
europepmc +1 more source

