Results 11 to 20 of about 131,803 (256)
Nuclear epidermal growth factor receptor as a therapeutic target
Exploration of Targeted Anti-tumor Therapy, 2023 Epidermal growth factor receptor (EGFR) is one of the most well-studied oncogenes with roles in proliferation, growth, metastasis, and therapeutic resistance.
Benjamin Atwell +2 more
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Lipids in Health and Disease, 2022 Background Hepatic caveolin-1 (CAV1) is reduced in cholesterol gallstone disease (CGD). Mice with CAV1 deficiency were prone to develop CGD. However, it remains unknown whether restored hepatic CAV1 expression prevents the development of CGD.
Sha Li +5 more
doaj +1 more source
Theragnostic perspectives of Mucin 1 for oral cancer
Oral Oncology ReportsDharmaraj Senthilkumar +1 more
doaj +2 more sources
Novel roles for mucin 1 in the kidney [PDF]
Current Opinion in Nephrology and Hypertension, 2017 Recent studies in the kidney have revealed that the well characterized tumor antigen mucin 1 (MUC1/Muc1) also has numerous functions in the normal and injured kidney.Mucin 1 is a transmembrane mucin with a robust glycan-dependent apical targeting signal and efficient recycling from endosomes.
Al-bataineh, Mohammad +2 more
openaire +2 more sources
Expression of aberrantly glycosylated Mucin‐1 in ovarian cancer [PDF]
Histopathology, 2010 Van Elssen C H M J, Frings P W H, Bot F J, Van de Vijver K K, Huls M B, Meek B, Hupperets P, Germeraad W T V & Bos G M J (2010) Histopathology57, 597–606 Expression of aberrantly glycosylated Mucin‐1 in ovarian cancerAims: Mucin 1 (MUC1) is an important tumour‐associated antigen (TAA), both overexpressed and aberrantly glycosylated in ...
Van Elssen, Catharina H. M. J. +8 more
openaire +3 more sources
Mucin Level as a Potential Biomarker for Breast Cancer Diagnosis
MCBS (Molecular and Cellular Biomedical Sciences), 2022 Background: Breast cancer is the second leading cause of cancer death and a health problem worldwide. Secreted mucins are upregulated in ductal adenocarcinoma of the breast, however, the use of mucin as breast cancer biomarker has not been established ...
Tagwa Sayed Abdihalim +1 more
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Annexin A1/Formyl Peptide Receptor Pathway Controls Uterine Receptivity to the Blastocyst
Cells, 2020 Embryo implantation into the uterine wall is a highly modulated, complex process. We previously demonstrated that Annexin A1 (AnxA1), which is a protein secreted by epithelial and inflammatory cells in the uterine microenvironment, controls embryo ...
Cristina B. Hebeda +7 more
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Bmi-1 regulates mucin levels and mucin O-glycosylation in the submandibular gland of mice.
PLoS ONE, 2021 Mucins, the major components of salivary mucus, are large glycoproteins abundantly modified with O-glycans. Mucins present on the surface of oral tissues contribute greatly to the maintenance of oral hygiene by selectively adhering to the surfaces of ...
Akihiko Kameyama +2 more
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Mouse mucin 1 (MUC1) defined by monoclonal antibodies [PDF]
International Journal of Cancer, 1998 Mucins are highly expressed in many different human cancers and numerous murine monoclonal antibodies (MAbs) to human mucins, particularly Mucin 1 (MUC1), have been produced. However, no such antibodies to murine mucin 1 (muc1) have been described and we now describe 6 different antibodies produced to murine muc1 and to human MUC1 cytoplasmic tail ...
P X, Xing +7 more
openaire +2 more sources
Kidney International Reports, 2017 Sequencing peptides included in the urinary proteome identifies the parent proteins and may reveal mechanisms underlying the pathophysiology of chronic kidney disease.
Zhen-Yu Zhang +15 more
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