Results 111 to 120 of about 21,379,209 (297)

VAMP8 mucin exocytosis attenuates intestinal pathogenesis by Entamoeba histolytica

, 2017
The intestinal mucosa encounters a barrage of ingested insults within the host yet under homeostasis elegantly facilitates nutrient absorption and sustenance of the commensal microbiota. An essential defence mechanism employed by the host is limiting the
Steve Cornick, Kris Chadee, France Moreau, Herbert Y. Gaisano   +3 more
core   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Differential expression of mucin 1 and mucin 2 in colorectal cancer

World Journal of Gastroenterology, 2018
To determine tissue expression (mRNA, protein) of two types of mucins [mucin 1 (MUC1) and mucin 2 (MUC2)] in patients with colorectal cancer (CRC).Expression of membrane-bound mucin (MUC1) and secretory mucin (MUC2) in CRC (mRNA, protein) were analyzed in tissue material including fragments of tumors obtained from CRC patients (n = 34), and fragments ...
Kasprzak, Aldona, Siodła, Elżbieta, Andrzejewska, Małgorzata, Szmeja, Jacek, Seraszek-Jaros, Agnieszka, Cofta, Szczepan, Szaflarski, Witold   +6 more
openaire   +2 more sources

The isolation, purification, tissue localization and identification of a glycoprotein found in the crude mucus gel of patients with carcinoma of the stomach

, 2008
Includes bibliographical references (leaves 101-138).The thin layer of crude mucus lining the human gastric mucosa protects the delicate gastric epithelium from the high shear forces associated with digestion. Gastric mucus is composed largely of water (>
Nthato, Chirwa
core  

An Edible Biohybrid Platform Accomplishes In Situ Fenton‐Mediated Enteral Nanoplastics Aging and Excretion

Advanced Science, EarlyView.
An edible biohybrid platform triggers nanoplastics (NPs) aging and agglomeration by in situ generating hydroxyl radicals within the intestine. The enlarged NPs are unable to penetrate the intestine and are subsequently excreted. Simultaneously, probiotic biofilms reinforce the intestinal barrier.
Su Zhou, Anran Yan, Haowei Guo, Ping Chen, Qiang Chu   +4 more
wiley   +1 more source

Histopathological and ultrastructural evaluations of giant African snail (Achatina fulica) mucin and alginate hydrogel on cutaneous wound healing in rats

Open Veterinary Journal
Background: Wound healing is a complex biological process that involves inflammation, cellular proliferation, and tissue remodeling. Efficient and prompt wound repair is critical for infection prevention and tissue integrity restoration.
Mohammad Reza Salahi, Mohammad Mahdi Molaei, Shahrzad Azizi, Pourya Mohammadi, Maziar Jajarmi   +4 more
doaj   +1 more source

Role of mucin 1 in Malaria-Associated Acute Respiratory Distress Syndrome

, 2023
This study investigated the role of mucin 1 in the development of malaria-associated acute respiratory distress syndrome. Mucin 1 has an important role in maintaining inflammatory response.
Raj Sanjiv Khatri (20325480)
core  

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Mucin 1-mediated chemo-resistance in lung cancer cells

Oncogenesis, 2016
AbstractPaclitaxel (PTX) is a commonly used drug to treat diverse cancer types. However, its treatment can generate resistance and the mechanisms of PTX-resistance in lung cancers are still unclear. We demonstrated that non-small cell lung cancers (NSCLCs) survive PTX treatment.
Ham, S. Y., Kwon, T., Bak, Y., Yu, H., Hong, J., Lee, S. K., Yu, D-Y, Yoon, D-Y   +7 more
openaire   +3 more sources

Gastric remnant carcinoma : histochemical and immunohistochemical profile

, 2004
Includes bibliographical references (leaves 52-65).Gastric remnant carcinoma (GRC) is a gastric cancer that develops in gastric remnant more than five years after resection for benign disease. GRC comprises 1 %-9% of all gastric cancers.
Elazzabi, Tawfik
core