Results 41 to 50 of about 131,847 (256)

Smoking-associated increase in mucins 1 and 4 in human airways [PDF]

Respiratory Research, 2020
Abstract Rationale Smoking-related chronic obstructive pulmonary disease (COPD) is associated with dysregulated production of mucus. Mucins (MUC) are important both for mucus secretion and epithelial defense. We have examined the distribution of MUC1 and MUC4 in the airway epithelial cells of never-smokers and smokers ...
Merikallio, H. (Heta), Kaarteenaho, R. (Riitta), Lindén, S. (Sara), Padra, M. (Médea), Karimi, R. (Reza), Li, C.-X. (Chuan-Xing), Lappi-Blanco, E. (Elisa), Wheelock, Å. M. (Åsa M.), Sköld, M. C. (Magnus C.)   +8 more
openaire   +5 more sources

MUC1 aptamer-tethered H40-TEPA-PEG nanoconjugates for targeted siRNA-delivery and gene silencing in breast cancer cells

Frontiers in Bioengineering and Biotechnology
With a prevalence of 12.5% of all new cancer cases annually, breast cancer stands as the most common form of cancer worldwide. The current therapies utilized for breast cancer are constrained and ineffective in addressing the condition.
Rajesh Salve, Rajesh Salve, Niladri Haldar, Niladri Haldar, Aazam Shaikh, Aazam Shaikh, Rajkumar Samanta, Rajkumar Samanta, Devyani Sengar, Devyani Sengar, Surajit Patra, Surajit Patra, Virendra Gajbhiye, Virendra Gajbhiye   +13 more
doaj   +1 more source

Investigation of the Effect of Alkali Modification of Mucin on Some Properties of Metronidazole Bioadhesive Tablets

Journal of Applied Sciences and Environmental Management, 2015
The objective of this study was to investigate the effect of alkali treatment of mucin on the mucoadhesive properties and tablet parameters of metronidazole tablets.
SO Eraga, MI Arhewoh, CO Okogbenin, MA Iwuagwu   +3 more
doaj   +1 more source

Cornu aspersum mucin attenuates indomethacins-induced gastric ulcers in mice via alleviating oxidative stress and inflammation

Heliyon, 2023
In the past three decades, a significant progress has been made in the prevention and treatment of gastric ulcers. The incidence of the disease has decreased, but gastric ulcer is still a medical problem.
Maha B. Salem, Mohamed Elzallat, Dina Mostafa Mohammed, Safia Samir, Olfat A. Hammam, Marwa Tamim A. Abdel-Wareth   +5 more
doaj   +1 more source

The Effect of Acid Modification of Porcine Mucin on Its Drug Release and Skin Permeation Properties in Insulin Transdermal Films

Pharmaceutical and Biomedical Research, 2020
Background: The transdermal delivery of insulin involving the use of polymers has been extensively reported. More recently, the use of mucoadhesive or bioadhesive polymers as an insulin base in its formulation is gaining attention possibly due to the ...
Sylvester O. Eraga, Matthew I. Arhewoh, Magnus A. Iwuagwu   +2 more
doaj   +1 more source

Mucin-1-Antibody-Conjugated Mesoporous Silica Nanoparticles for Selective Breast Cancer Detection in a Mucin-1 Transgenic Murine Mouse Model [PDF]

Journal of Biomedical Nanotechnology, 2016
Mucin-1 (MUC1), a transmembrane glycoprotein is aberrantly expressed on ~90% of breast cancer and is an excellent target for nanoparticulate targeted imaging. In this study, the development of a dye-doped NIR emitting mesoporous silica nanoparticles platform conjugated to tumor-specific MUC1 antibody (ab-tMUC1-NIR-MSN) for in vivo optical detection of ...
Didier, Dréau, Laura Jeffords, Moore, Merlis P, Alvarez-Berrios, Mubin, Tarannum, Pinku, Mukherjee, Juan L, Vivero-Escoto   +5 more
openaire   +2 more sources

A Monoclonal Antibody Against the Oncogenic Mucin 1 Cytoplasmic Domain [PDF]

Hybridoma, 2011
Mucin 1 (MUC1) is a heterodimeric protein that is aberrantly overexpressed in diverse human carcinomas and certain hematologic malignancies. The transmembrane MUC1-C subunit confers tumorigenicity and is a target for anti-cancer drug development. In this regard, the MUC1-C cytoplasmic domain interacts with multiple effectors that have been linked to ...
Govind, Panchamoorthy, Hala, Rehan, Akriti, Kharbanda, Rehan, Ahmad, Donald, Kufe   +4 more
openaire   +2 more sources

Lubiprostone stimulates small intestinal mucin release

BMC Gastroenterology, 2012
Background Lubiprostone is a synthetic bicyclic fatty acid derivative of prostaglandin E1 (PGE1) used for chronic constipation. The best known action of lubiprostone is simulation of Cl- dependent fluid secretion.
De Lisle Robert C
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source