Results 281 to 290 of about 27,431,650 (340)

Tetrahedral DNA Nanostructure with Multiple Target-Recognition Domains for Ultrasensitive Electrochemical Detection of Mucin 1.

Analytical Chemistry, 2022
In this work, a tetrahedral DNA nanostructure (TDN) designed with multiple biomolecular recognition domains (m-TDN) was assembled to construct an ultrasensitive electrochemical biosensor for the quantitative detection of tumor-associated mucin 1 (MUC-1 ...
Wenxi Hu, Yuan-yuan Chang, Junqing Huang, Y. Chai, R. Yuan   +4 more
semanticscholar   +1 more source

Ultrasensitive dual-signal electrochemical ratiometric aptasensor based on Co-MOFs with intrinsic self-calibration property for Mucin 1.

Analytica Chimica Acta, 2022
The concentration of tumor biomarker Mucin 1 (MUC 1) is highly related with many diseases, which can be employed for the early diagnosis of cancer. In this paper, an electrochemical ratiometric aptasensor with intrinsic self-calibration property for the ...
Faming Xie, Yu-long Li, Yan Guan, Jiawei Liu, Tong Yang, Guo-jiang Mao, Yuan Wu, Yunhui Yang, Rong Hu   +8 more
semanticscholar   +1 more source

Mucin-1 conjugated polyamidoamine-based nanoparticles for image-guided delivery of gefitinib to breast cancer.

International Journal of Biological Macromolecules, 2021
PAMAM dendrimers (PAMs) are a group of polymeric macromolecules with distinctive physicochemical features, which can make them multifunctional theranostic nanoparticles (NPs).
Poorya Najjari Nabi, Nasim Vahidfar, M. Tohidkia, A. Hamidi, Y. Omidi, Ayuob Aghanejad   +5 more
semanticscholar   +1 more source

Aptamer-guided DNA tetrahedrons as a photo-responsive drug delivery system for Mucin 1-expressing breast cancer cells

Applied Materials Today, 2021
Photosensitizers are crucial for photodynamic therapy. However, conventional photosensitizers have poor selectivity, and their targeted delivery by nanocarriers has become a major research focus. The aim of this study was to construct a targeted delivery
Lingxian Meng, Wenjuan Ma, Mei Zhang, Ronghui Zhou, Qirong Li, Yue Sun, Weidong Fu, Xiaoxiao Cai, Yunfeng Lin   +8 more
semanticscholar   +1 more source

Advances in the Applications of Mucin 1 in Cancer Therapy

Journal of Biomedical Nanotechnology, 2023
Mucin 1 belongs to the membrane-binding mucoprotein subfamily, which is normally a highly O-glycosylated polymer protein that is mainly expressed in epithelial cells and some hematopoietic cells. Mucin 1 was overexpressed in many cancer tissues compared to normal tissue with a lower degree of glycosylation.
Ben Yang, Hanyue Li, Fei Wang, Changjun Zuo, Yicheng Qi, Tiantian Song, Sipeng Sun, Rongguan Kou, Anping Wang, Hui Wang, Mengqi Shi, Wenjing Yu, Yubing Wang, Zhiqin Gao   +13 more
openaire   +1 more source

A novel dual signal and label-free electrochemical aptasensor for mucin 1 based on hemin/graphene@PdPtNPs.

Biosensors & bioelectronics, 2020
A dual signal and label-free electrochemical aptasensor for mucin 1 was constructed based on hemin/graphene@PdPtNPs nanocomposite (H-Gr@PdPtNPs). Hemin attached on the graphene surface not only improves the solubility of graphene and acts as an in-situ ...
Guojuan Zhang, Zhiguang Liu, Lifang Fan, Yujie Han, Yujing Guo   +4 more
semanticscholar   +1 more source

Biology, Significance and Immune Signaling of Mucin 1 in Hepatocellular Carcinoma

Current Cancer Drug Targets, 2022
Abstract:Mucin 1 (MUC 1) is a highly glycosylated tumor-associated antigen (TAA) overexpressed in hepatocellular carcinoma (HCC). This protein plays a critical role in various immune-mediated signaling pathways at its transcriptional and post-transcriptional levels, leading to immune evasion and metastasis in HCC.
Lekshmi R. Nath, Ayana R. Kumar, Aswathy R. Devan, Bhagyalakshmi Nair, Reshma Ravindran Nair   +4 more
openaire   +2 more sources

Role of Mucin 1 and Glycodelin A in recurrent implantation failure

Fertility and Sterility, 2015
To evaluate and compare the levels of Mucin 1 (MUC-1) and Glycodelin A (GdA) in precisely timed endometrial biopsies and blood samples taken from women with recurrent implantation failure, and women with proven fertility, in a control group.Molecular studies in human blood and tissue.University hospital.Women with recurrent implantation failure and ...
Ercan Bastu, Mehmet F. Mutlu, Cenk Yasa, Ozlem Dural, Asli Nehir Aytan, Cem Celik, Faruk Buyru, John Yeh   +7 more
openaire   +2 more sources

Electrochemiluminescence Enhanced by Restriction of Intramolecular Motions (RIM): Tetraphenylethylene Microcrystals as a Novel Emitter for Mucin 1 Detection.

Analytical Chemistry, 2019
Apart from the reported energy transfer mechanism of aggregation-induced electrochemiluminescence (AI-ECL) enhancement, a new strategy named restriction of intramolecular motions-driven ECL (RIM-ECL) enhancement is first proposed based on the phenomenon ...
Ming-Hui Jiang, Sheng-Kai Li, X. Zhong, W. Liang, Y. Chai, Ying Zhuo, R. Yuan   +6 more
semanticscholar   +1 more source

Update on Mucin-1 immunotherapy in cancer: a clinical perspective

Expert Opinion on Biological Therapy, 2015
Mucin 1 (MUC1) is particularly well suited as a cancer immunotherapy target due to the elevated protein expression and aberrant forms associated with malignancy. A variety of therapeutic strategies have been explored, including antibodies intended to induce cancer cell destruction, and vaccinations with peptides, tumor extracts, and gene expression ...
Gareth, Rivalland, Bruce, Loveland, Paul, Mitchell   +2 more
openaire   +2 more sources