Results 61 to 70 of about 125,867 (236)
Advanced Healthcare Materials, EarlyView.In ophthalmology, living biomaterials such as living contact lenses appear promising for sustained drug delivery or biosensing. The cytocompatibility of Cg‐PVA hydrogels, developed as a model living contact lens, is investigated with the ocular surface, showing their potential translation to the clinic.
Krupansh Desai +6 more
wiley +1 more source
European Journal of Inflammation, 2021 Objectives Mucin phenotype is a tool to classify gastric cancer, but the relationship between mucin phenotype and its malignancy is still controversial.
Takanobu Akaishi +7 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement +12 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2020 The homing of lymphocytes from blood to gut-associated lymphoid tissue is regulated by interaction between integrin α4β7 with mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) expressed on the endothelium of high endothelial venules (HEVs ...
MengYa Yuan +7 more
doaj +1 more source
Immunobiology of human mucin 1 in a preclinical ovarian tumor model [PDF]
Oncogene, 2012 Epithelial ovarian cancer is an aggressive malignancy, with a low 5-year median survival. Continued improvement on the development of more effective therapies depends in part on the availability of adequate preclinical models for in vivo testing of treatment efficacy.
R A, Budiu +6 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Ferritin‐doped hybrid nanoparticles triggered accurate tumor‐specific hemorrhage for enhanced in situ photothermal therapy and evoked anti‐tumor immunity. Notably, HFn/GA‐Fe specifically induced tumor hemorrhage 12 h after intravenous injection, resulting in visible color darkening. Through photoacoustic imaging, tumor vessels could be clearly observed
Haidong Zha +7 more
wiley +1 more source
Respiratory Research, 2007 Background Nitric oxide (NO) is generally increased during inflammatory airway diseases. This increased NO stimulates the secretion of mucin from the goblet cell and submucosal glands but the mechanism is still unknown precisely.
Kim Kwan +8 more
doaj +1 more source
High-resolution structure of intramolecularly proteolyzed human mucin-1 SEA domain
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2020 SEA domains are ubiquitous in large proteins associated with highly glycosylated environments. Certain SEA domains undergo intramolecular proteolysis involving a nucleophilic attack of a serine hydroxyl group on the preceding glycine carbonyl. The mucin-1 (MUC1) SEA domain has been extensively investigated as a model of intramolecular proteolysis ...
Noguera, Martín Ezequiel +2 more
openaire +4 more sources
Advanced Healthcare Materials, EarlyView.To dissect how mechanical forces influence intestinal physiology, we developed a stretchable 3D colon‐on‐chip that integrates tunable topography, stiffness and peristalsis‐like motion within a physiologically relevant microenvironment. We showed that stretching is a dominant factor governing epithelial behavior, markedly enhancing proliferation and ...
Moencopi Bernheim‐Dennery +10 more
wiley +1 more source
Mucin 1 Aberrantly Expresses in Goat Mammary Carcinoma [PDF]
Journal of Stem Cell Research & Therapeutics, 2017 The objective of this study was to determine if expression of mucin MUC and abundance of collagen fibers is associated with the incidence of goat mammary cancer MUC often expressed in metastatic cancers and has been used as a diagnostic marker for metastatic progression Similarly collagen density affects tumor microenvironment and promotes invasion ...
openaire +1 more source