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The complexity of mucins

Biochimie, 1988
Mucins represent the main components of gel-like secretions, or mucus, secreted by mucosae or some exocrine glands. These high-molecular-weight glycoproteins are characterized by the large number of carbohydrate chains O-glycosidically linked to the peptide. The determination of mucin molecular weight and conformation has been controversial for several
Lafitte Jj   +7 more
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Mucins and mucin binding proteins in colorectal cancer

Cancer and Metastasis Reviews, 2004
Mucins are high-molecular weight epithelial glycoproteins with a high content of clustered oligosaccharides O-glycosidically linked to tandem repeat peptides rich in threonine, serine, and proline. There are two structurally and functionally distinct classes of mucins: secreted gel-forming mucins (MUC2, MUC5AC, MUC5B, and MUC6) and transmembrane mucins
Robert S. Bresalier, James C. Byrd
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Mucinous syringometaplasia

Journal of the American Academy of Dermatology, 1984
This is a clinicopathologic study of six patients with mucinous syringometaplasia, which was diagnosed histologically. Biopsies revealed a focal invagination of the epidermis lined by squamous epithelium, with one or several eccrine ducts leading into the vagination. The eccrine duct epithelium contained mucin-laden goblet cells, and there was mucinous
K, Scully, D, Assaad
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Mucus and Mucins

Otolaryngologic Clinics of North America, 2010
A variety of mucoactive medications are used to treat chronic lung disease. When evaluating the role of the cough, it must be considered as an important protective mechanism. Therefore, it may be more important to improve the effectiveness of cough than to suppress or eliminate a chronic cough in patients with chronic lung disease.
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Mucins and Immune Reactions to Mucins in Ulcerative Colitis

Digestion, 2001
Ulcerative colitis (UC) is an inflammatory bowel disease of undetermined etiology. Mucins, mainly produced by goblet cells, protect colon cells from various kinds of stress. Alteration in the quality or quantity of mucins may be the cause of the disease. Another possible cause is immune reactions to colonic cells.
Tadao Ishida   +6 more
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Hibiscin for Mucin

Stain Technology, 1982
Yamamota and Oshima in 1932 extracted a crystalline anthocyanin coloring material from the flowers of Hibiscus sabdariffa which they called hibiscin. In 1976 El-Aaser and Gowali successfully used hibiscin as a stain for DNA on frozen sections. This paper reports on the staining capacity of this dye for epithelial mucin in paraffin sections.
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Mucin Purification and Printing Natural Mucin Microarrays

2022
Mucin glycosylation is the key facilitator of microbial attachment and nutrition and it varies according to biological location, health and disease status, microbiome composition, infection, and multiple other factors. Mucin glycans have also been reported to attenuate pathogen virulence and mediate biofilm dispersal.
Marie, Le Berre   +5 more
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Mucinous Nevus

The Journal of Dermatology, 2005
AbstractA 15‐year‐old boy first noticed multiple firm papules on his right upper chest two years before presenting to our clinic. These papules were densely distributed and showed epidermal nevus‐like linear arrangement at some sites. The number, size, and distribution of these papules remained unchanged for one year of our observation.
Maki, Yokogawa   +4 more
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Mucin Exocytosis

American Review of Respiratory Disease, 1991
Mucins produced by goblet cells of the respiratory mucosa are condensed while stored in secretory granules. Mucin condensation and its decondensation upon exocytosis can be explained by the theory of polymer gel phase transition. After the opening of a secretory pore, Ca2+ inside the granule is exchanged for extracellular Na+. Na/Ca exchange triggers a
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Mucins and Mucus

2015
Mucosal surfaces are exposed to the external environment and pathogens and are therefore protected by a secreted layer of mucus rich in mucin glycoproteins, which are the main components of mucus. Mucus provides physical protection and hydration, excludes pathogens, and is a reservoir for antimicrobial molecules.
McGuckin, Michael A.   +2 more
openaire   +3 more sources

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