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Pancreatic Cancer Early Detection Biomarkers for High‐Risk Individuals: Insights From the PRECEDE Consortium

International Journal of Cancer, Volume 159, Issue 8, Page 1873-1883, 15 October 2026.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to its asymptomatic progression, late‐stage diagnosis, and treatment resistance. Efforts in early detection have centered on identifying imaging features and liquid biopsy biomarkers capable of detecting PDAC and its high‐grade precursors before clinical symptoms ...
Christine Worthington, Maria Raitses‐Gurevich, Giulio Innamorati, Phil A. Hart, Thomas M. Wilkie, Noam Tau, Dana Brin, Doron Yablecovitch, Ido Laish, Dove Keith, Kurt Giles, Jennifer B. Permuth, Diane M. Simeone, George Zogopoulos, Randall E. Brand, John J. Graff, Julie Earl, On behalf of the PRECEDE Consortium, Nikhil Agarwal, Laufey Amundadottir, Michelle Anderson, Ajay Bansal, Todd Bauer, Georg Beyer, Yan Bi, Erkut Borazanci, Randy Brand, Teri Brentnall, Carol Burke, Darren Carpizo, Saurabh Chawla, Daniel Chung, Sourat Darabi, Michael Demeure, Timothy Donahue, Julie Earl, Whitney Espinel, James Farrell, Vigdís Fjóla Stefánsdóttir, Jared Forrester, Eitan Friedman, Paul Franklin, Srinivas Gaddam, Ana García García de Paredes, Steven Gallinger, Talia Golan, Ora Gordon, Robert Grant, William Greenhalf, Eli Marie Grindedal, Aaron Grossberg, Brenda Hafers, Heather Hannon, Sigurdís Haraldsdóttir, Stefán Haraldsson, Peter Hegyi, Melissa Hogg, Amy de Haar‐Holleman, Susan Hong, Greg Idos, Edward Kim, Fay Kastrinos, Bryson Katona, Vivek Kaul, Derk Klatte, Kelsey Klute, Kimberly Ku, Sonia Kupfer, Rich Kwon, Rosario Ligresti, James James Lin, Wei‐Chih (David) Liao, Aimee Lucas, Nipun Merchant, Andrew Metz, Whitney Maxwell, James McLoughlin, Sodech Miclette, Xavier Molero, Leticia Moreira, Takuji Okusaka Chigusa Morizane, Joanne Ngeow, Salvatore Paiella, Jennifer Permuth, Maricel Purcell, Joshua Raff, Vineet Rolston, Intan Schrader, Rosie Sears, Yan‐Shen Shan, Diane Simeone, Jens Siveke, Brett Sheppard, Tyler Stevens, Elena Stoffel, Dan Sussman, Margaret Tempero, Jose Trevino, Jennifer Valerin, Eva Vaquero, Ray Wadlow, Garrett Ward, David Weinberg, Ronald Wolf, Dana Zakalik, George Zogopoulos   +105 more
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Mucinous adenocarcinoma of the prostate

Human Pathology, 1986
A case of mucinous adenocarcinoma of the prostate that was diagnosed with the aid of prostate-specific antigen immunoperoxidase staining is reported. Focal areas of the tumor, which were morphologically similar to the remainder of the tumor, stained with neuron-specific enolase by an immunoperoxidase technique and with the Grimelius stain.
D G, Odom, C F, Donatucci, G E, Deshon
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Prostatic mucinous adenocarcinoma

Urology, 1984
Primary mucinous adenocarcinoma of the prostate is rare. It is necessary to exclude extraprostatic primary sources, particularly from the gastrointestinal tract and the urinary bladder. Immunoperoxidase stain can serve the purpose of differential diagnosis. Usually, the presence of mucin in prostatic carcinoma is associated with a less aggressive tumor.
Y, Hsueh, S H, Tsung
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Mucinous (colloid) adenocarcinoma

The Japanese Journal of Thoracic and Cardiovascular Surgery, 2005
We describe a case of primary mucinous (colloid) adenocarcinoma of the lung. The patient was a 61-year-old male with a peripheral mass of the left lung. Retrospectively, the mass, which showed slow growth later, could be seen in a chest X-ray 3 years before surgery.
Seiji, Okimasa, Noriaki, Kurimoto
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Mucinous Adenocarcinoma of the Prostate

Journal of Urology, 1977
The third case of mucous-forming adenocarcinoma of the prostate with metastases to the bone is reported. The primary tumor was unresponsive to definitive radiotherapy and subsequent metastases to the lung, liver and bone failed to respond to hormonal manipulation and chemotherapy.
G, Chica, D E, Johnson, A G, Ayala
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Perianal mucinous adenocarcinoma

Journal of Surgical Oncology, 1997
Perianal mucinous adenocarcinoma is a rare variant of anal canal epithelioid tumors. Our objective in this report is to examine the clinical features, pathology, treatment, and outcome for patients with perianal mucinous adenocarcinoma.A retrospective review identified four patients with histologically proven perianal mucinous adenocarcinoma.
T, Anthony, C, Simmang, E L, Lee, R H, Turnage   +3 more
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Mucinous adenocarcinoma of prostate

Urology, 1979
Primary mucinous adenocarcinoma of the prostate is rare. The presence of mucin in prostatic carcinoma is usually associated with decreased tumor aggressiveness and increased survival rates. When mucinous adenocarcinoma of the prostate is found, it is necessary to exclude extraprostatic primary sources particularly from the urinary bladder and the ...
R P, Cricco, J, Kassis
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Mucinous adenocarcinoma of prostate

Urology, 1989
The twenty-eighth case of mucinous adenocarcinoma of the prostate is reported. This microscopic variety of prostatic cancer is rare and aggressive; it metastasizes to bone, does not seem to respond to hormone therapy, and reacts positively to immunoperoxidase stain.
R K, Manne, F S, Haddad
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Mucinous adenocarcinoma in defunctionalized bladders

Urology, 1995
Primary adenocarcinoma of the bladder accounts for less than 2% of all bladder cancers. There is no report of such a case in a defunctionalized bladder. All reported cases of carcinoma in defunctionalized bladders were either squamous cell, signet ring cell, or transitional cell carcinoma, detected within an average of 5 years after urinary diversion ...
B, Djavan, S E, Litwiller, S, Milchgrub, C G, Roehrborn   +3 more
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Mucinous Adenocarcinoma of the Eyelid

Archives of Ophthalmology, 1984
A 52-year-old man had a rapidly growing cystic-appearing lesion on his lower eyelid. Excisional biopsy disclosed a mucinous sweat gland adenocarcinoma and the mucinous material (presumably sialomucin) accounted for the transillumination property of the tumor. These carcinomas should be considered in the differential diagnosis of cystic eyelid lesions.
T W, Gardner, R B, O'Grady
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