Results 31 to 40 of about 39,372 (225)

Cervical adenocarcinoma presenting as an ovarian torsion

Gynecologic Oncology Reports
Background: Cervical adenocarcinoma is increasing in incidence and can rarely present as ovarian metastasis.Case: A 41-year-old female who presented with left lower quadrant pain and vomiting.
M. Mvula, S. Roychoudhury, K. King, N. Aravindan, C. Chan, V. John, J. Whyte, GL. Goldberg   +7 more
doaj   +1 more source

Role of colectomy in the management of appendiceal tumors: a retrospective cohort study

BMC Gastroenterology, 2023
Background Appendiceal tumors represent a range of histologies that vary in behavior. Recommendations for treatment with appendectomy versus right hemicolectomy (RHC) for different tumor types are evolving and sometimes conflicting.
Victoria A. Marks, Daniel Kerekes, Samuel Butensky, Nita Ahuja, Caroline Johnson, Kiran Turaga, Sajid A. Khan   +6 more
doaj   +1 more source

A minor (<50%) signet-ring cell component associated with poor prognosis in colorectal cancer patients: a 26-year retrospective study in China.

PLoS ONE, 2015
BackgroundWe performed a retrospective study to determine the cancer-specific survival of colorectal cancer patients with a component of signet-ring cells or mucin comprising < 50% of the tumor mass.MethodsA total of 2454 patients seen in our hospital ...
Yinuo Tan, Jianfei Fu, Xiaofen Li, Jiao Yang, Mengjie Jiang, Kefeng Ding, Jinghong Xu, Jun Li, Ying Yuan   +8 more
doaj   +1 more source

Calcified mucinous adenocarcinoma of the stomach metastatic to the iris: a case report

Journal of Medical Case Reports, 2019
Background Gastric cancer has a wide spectrum of clinical features, imaging manifestations, and pathology. Punctate calcifications in gastric cancer are infrequent but are usually found in mucinous adenocarcinoma.
Miki Kaneko, Tadashi Namisaki, Hiroaki Takaya, Hitoshi Mori, Mitsuteru Kitade, Yasushi Okura, Kenichiro Seki, Shinya Sato, Keisuke Nakanishi, Koh Kitagawa, Takahiro Ozutsumi, Naotaka Shimozato, Kosuke Kaji, Tomoyuki Otani, Tokiko Nakai, Chiho Obayashi, Akira Mitoro, Junichi Yamao, Hitoshi Yoshiji   +18 more
doaj   +1 more source

Mucinous Carcinoma of the Skin: A Case Report

Journal of Nepal Medical Association, 2022
Primary mucinous carcinoma of the skin is a rare malignant neoplasm showing predilection to the periorbital region. These tumours are indolent and low-grade, with a tendency for local, sometimes multiple, recurrences.
Adarsh Kumar Jhunjhunwala, Dilasma Gharti Magar, Dipesh Upreti, Niku Thapa, Arnab Ghosh, Sushma Thapa, Sudeep Regmi, Bishowdeep Timilsina   +7 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source