Results 81 to 90 of about 362,300 (406)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Pancreatic cysts suspected to be branch duct intraductal papillary mucinous neoplasm without concerning features have low risk for development of pancreatic cancer. [PDF]

, 2015
BackgroundThe risk of developing pancreatic cancer is uncertain in patients with clinically suspected branch duct intraductal papillary mucinous neoplasm (BD-IPMN) based on the "high-risk stigmata" or "worrisome features" criteria proposed in the 2012 ...
Fehmi, Syed A, Giap, Andrew Q, Gonzalez, Ingrid, Hunt, Gordon C, Krinsky, Mary L, Kwong, Wilson T, Lawson, Robert D, Savides, Thomas J, Slezak, Jeff, Tang, Raymond S   +9 more
core   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Primary lung invasive adenocarcinoma misdiagnosed as infectious pneumonia in 18F-FDG PET/CT:A case report

Radiology Case Reports, 2022
A 64-year-old woman presented to our hospital with cough and a large amount of white foam sputum, F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) showed diffuse ground-glass opacities in both lungs, which was ...
Yuping Han, MD, Yongjun Luo, MD, PhD
doaj  

A prognostic model of patients with ovarian mucinous adenocarcinoma: a population-based analysis

Journal of Ovarian Research, 2022
Background Ovarian mucinous carcinoma is a disease that requires unique treatment. But for a long time, guidelines for ovarian serous carcinoma have been used for the treatment of ovarian mucinous carcinoma.
Li Yang, Jinfen Yu, Shuang Zhang, Yisi Shan, Yajun Li, Liugang Xu, Jinhu Zhang, Jianya Zhang   +7 more
doaj   +1 more source

Phenotypic and Genotypic Appraisal of Pulmonary Mucinous Adenocarcinoma: A Retrospective Study

National Journal of Laboratory Medicine, 2023
Introduction: Lung cancer is the second most common cancer diagnosed in the world. According to GLOBOCAN 2020, it is approximately 11.4% of all malignancies and accounts for one in five cancer deaths worldwide.
VG Deepak Roshan, Ashwini Ramji, M Saravanan, Vipin Gopinath, Sangeetha K Nayanar   +4 more
doaj   +1 more source

Incidence of lymph node metastases in clinical early-stage mucinous and seromucinous ovarian carcinoma: a retrospective cohort study [PDF]

, 2017
Objective: The use of lymph node sampling during staging procedures in clinical early-stage mucinous ovarian carcinoma (MOC) is an ongoing matter of debate. Furthermore, the incidence of lymph node metastases (LNM) in MOC in relation to tumour grade (G)
Buist, M.R., Coffelt, S.B., Kenter, G.G., Lok, C.A.R., van Baal, J.O.A.M., Van de Vijver, K.K., van der Noort, V., van Driel, W.J.   +7 more
core   +2 more sources

Metformin treatment for diabetes mellitus correlates with progression and survival in colorectal carcinoma [PDF]

, 2020
BACKGROUND: Diabetes mellitus is unfavorably associated with cancer risk. The purpose of this multi-disciplinary project was to evaluate a possible association of diabetes mellitus and other comorbidities and their treatment with progression of ...
Brown, Robert E., Cempírková, Dana, Dundr, Pavel, Gregorová, Jana, Grimmichová, Tereza, Heneberg, Petr, Janurová, Kateřina, Litschmannová, Martina, Pešta, Michal, Powell, Marta K., Třebický, Ferdinand   +10 more
core   +1 more source

Gene signature driving invasive mucinous adenocarcinoma of the lung

EMBO Molecular Medicine, 2017
Though invasive mucinous adenocarcinoma of the lung (IMA) is pathologically distinctive, the molecular mechanism driving IMA is not well understood, which hampers efforts to identify therapeutic targets.
M. Guo, K. Tomoshige, M. Meister, T. Muley, T. Fukazawa, T. Tsuchiya, Rebekah A. Karns, A. Warth, I. Fink-Baldauf, T. Nagayasu, Y. Naomoto, Yan Xu, M. Mall, Yutaka Maeda   +13 more
semanticscholar   +1 more source

Mucus Physically Restricts Influenza A Viral Particle Access to the Epithelium

Advanced Biology, EarlyView.
The infectious potential of respiratory viruses depends on their ability to navigate through a layer of mucus that serves as a protective barrier in the lung. It is demonstrated that influenza A virus penetration through mucus is significantly limited by the gel's internal microstructure and, to a lesser extent, by adhesive binding to mucin glycans ...
Logan Kaler, Elizabeth M. Engle, Maria Corkran, Ethan Iverson, Allison Boboltz, Maxinne A. Ignacio, Taj Yeruva, Margaret A. Scull, Gregg A. Duncan   +8 more
wiley   +1 more source