Results 101 to 110 of about 67,233 (350)

Mucin-Mimetic Glycan Arrays Integrating Machine Learning for Analyzing Receptor Pattern Recognition by Influenza a Viruses

, 2021
Taryn M. Lucas, Chitrak Gupta, Meghan O. Altman, Emi Sanchez, Matthew R. Naticchia, Pascal Gagneux, Abhishek Singharoy, Kamil Godula   +7 more
openalex   +1 more source

Single‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang   +12 more
wiley   +1 more source

Glyco-biomarkers: Potential determinants of cellular physiology and pathology [PDF]

, 2008
Once dismissed as just the icing on the cake, sugar molecules are emerging as vital components in life’s intricate machinery. Our understanding of their function within the context of the proteins and lipids to which they are attached has matured rapidly,
Alavi, A, Axford, JS
core   +2 more sources

BabA-mediated adherence of pediatric ulcerogenic H. pylori strains to gastric mucins at neutral and acidic pH

Virulence, 2018
Helicobacter pylori infection can result in non-ulcer dyspepsia (NUD), peptic ulcer disease (PUD), adenocarcinoma, and gastric lymphoma. H. pylori reside within the gastric mucus layer, mainly composed of mucins carrying an array of glycan structures ...
Macarena P. Quintana-Hayashi, Raquel Rocha, Médea Padra, Anders Thorell, Chunsheng Jin, Niclas G. Karlsson, Mónica Roxo-Rosa, Mónica Oleastro, Sara K. Lindén   +8 more
doaj   +1 more source

Mucus is more than just a physical barrier for trapping oral microorganisms

Journal of Oral Microbiology, 2020
Mucus is thought to serve as a protective coating on wet epithelial surfaces. Recent research has shown that glycans, which are branched sugar molecules found in mucin, a part of mucus, can prevent bacteria from communicating with each other and forming ...
Ingar Olsen
doaj   +1 more source

Mucin hypersecreting cholangiocarcinoma

The Korean Journal of Hepatology, 2008
Mucin hypersecreting cholangiocarcinoma Yoon-Mi Jeen, M.D., So-Young Jin, M.D.
Yoon Mi, Jeen, So Young, Jin
openaire   +2 more sources

Microenvironment Self‐Adaptive Nanoarmor to Address Adhesion‐ and Colonization‐Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease

Advanced Science, EarlyView.
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu, Yuyu Wu, Yingjie Chen, Xiyi Chen, Xingjie Zan, Yanlong Liu, Wujun Geng   +6 more
wiley   +1 more source

Efferocytosis‐Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer

Advanced Science, EarlyView.
Chemotherapy‐induced efferocytosis drives ovarian cancer stem cell enrichment. By engulfing apoptotic cancer cells, macrophages upregulate ODC1 and produce putrescine, which elevates osteopontin (OPN) expression. Secreted OPN then activates the CD44 receptor on cancer cells, promoting stemness and chemoresistance.
Wenhan Li, Feiquan Ying, Xinkai Pang, Qiulei Wu, Guoqing Li, Lin Huang, Jiayu Xin, Xiaoli Liu, Pan Liu, Xiaohan Xu, Shuran Tan, Yumei Gao, Tong Liu, Si Sun, Xiaoman Wang, Yiping Wen, Liqiong Cai, Shi Du, Yuan Zhang, Jing Cai   +19 more
wiley   +1 more source

Detection of inflammation- and neoplasia-associated alterations in human large intestine using plant/invertebrate lectins, galectin-1 and neoglycoproteins [PDF]

, 1998
Commonly, plant and invertebrate lectins are accepted glycohistochemical tools for the analysis of normal and altered structures of glycans in histology and pathology.
Bosbach, R., Brinck, U., Gabius, Hans-Joachim, Korabiowska, M.   +3 more
core   +1 more source

Fermented Lacticaseibacillus Paracasei Cultures Ameliorate Colitis by Modulating Microbiota‐Derived Tryptophan Metabolism and Macrophage Polarization

Advanced Science, EarlyView.
A solid‐state fermented probiotic (PYW) is developed using wheat bran as substrate, containing high viable Lacticaseibacillus paracasei and bioactive metabolites. PYW alleviates intestinal inflammation by gut microbiota composition, enriching indole derivatives, activating aryl hydrocarbon receptor signaling, and regulating macrophage polarization. PYW
Heng Zhang, Jingzhou Sun, Xin Zheng, Huiqing Yang, Aowen Xie, Yuxuan Ding, Yuxia Mei, Jinshan Li, Yuanliang Hu, Min Ren, Yangyang Liu, Yunxiang Liang   +11 more
wiley   +1 more source