Results 51 to 60 of about 31,045 (237)

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Engineering Resatorvid‐Loaded Sub‐Microgels of Epigallocatechin‐3‐gallate/Hyaluronic Acid to Treat Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
This study presents HAEP@Res sub‐microgels as a lung‐targeted delivery system integrating antioxidant activity with anti‐inflammatory therapy. The sub‐microgels demonstrate excellent biocompatibility, efficiently scavenge intracellular ROS, and downregulate pro‐inflammatory cytokines and genes in a Bleo‐induced ALI mouse model. These findings highlight
Bo Liu, Olawale Alimi Alimi, Benjamin Stearnes, Svetlana Romanova, Brady J. Sillman, Mena Asha Krishnan, Kristina Bailey, Benson J. Edagwa, Huanhuan Joyce Chen, Han‐jun Wang, Bin Duan   +10 more
wiley   +1 more source

A STUDY ON CHRONIC OTITIS MEDIA ACTIVE MUCOSAL TYPE WITH SINUSITIS AS FOCAL SEPSIS [PDF]

, 2012
AIM : To establish the role of Sinusitis as Focal sepsis in Chronic Otitis media active mucosal disease, to emphasizethe need of proper diagnostic endoscopic evaluation and improvement in middle ear mucosal disease status afterfunctional endoscopic sinus
Gopalakrishnan, Shankaranarayanan, Kumar, Sathish   +1 more
core   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Evaluation of Nasal Mucociliary Activity in Patients With Psoriasis Vulgaris

Dermatology Practical & Conceptual
Introduction: Psoriasis, a chronic inflammatory dermatological condition, is marked by recurring periods of activity and quiescence. This persistent inflammation contributes to a range of associated health issues.
Mehmet Akif Dundar, Selami Aykut Temiz, Ismail Hakkı Tuncez, Elif Emre, Sadettin Emre, Recep Dursun   +5 more
doaj   +1 more source

Pathological and cytological changes of the nasal mucosa in acute rhinosinusitis: the role of hyaluronic acid as supportive therapy [PDF]

, 2017
OBJECTIVE: The aim of this study was to evaluate the reparative role of hyaluronic acid in acute rhinosinusitis (ARS). PATIENTS AND METHODS: 48 patients affected by ARS were submitted to nasal endoscopy, nasal cytology, mucociliary transport evaluation (
ALTISSIMI, Giancarlo, CIOFALO, Andrea, FUSCONI, Massimo, Gelardi, Matteo, IANNELLA, GIANNICOLA, MAGLIULO, Giuseppe, PASQUARIELLO, BENEDETTA, SOLDO, Pietro, ZAMBETTI, Giampietro   +8 more
core  

Engineered Living Systems With Self‐Organizing Neural Networks: From Anatomy to Behavior and Gene Expression

Advanced Science, EarlyView.
Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat, Laurie O'Neill, Léo Pio‐Lopez, Megan M. Sperry, Patrick Erickson, Tiffany Lin, Michael Levin   +6 more
wiley   +1 more source

Transport efficiency of metachronal waves in 3d cilia arrays immersed in a two-phase flow

, 2016
The present work reports the formation and the characterization of antipleptic and symplectic metachronal waves in 3D cilia arrays immersed in a two-fluid environment, with a viscosity ratio of 20.
'Ortona, Umberto D, Chateau, Sylvain, Favier, Julien, Poncet, Sébastien   +3 more
core   +3 more sources

Non-invasive airway health assessment: Synchrotron imaging reveals effects of rehydrating treatments on mucociliary transit in-vivo [PDF]

, 2014
To determine the efficacy of potential cystic fibrosis (CF) therapies we have developed a novel mucociliary transit (MCT) measurement that uses synchrotron phase contrast X-ray imaging (PCXI) to non-invasively measure the transit rate of individual ...
A Livraghi, A Snigirev, A Stocker, AJ Hirsh, B Button, BR Grubb, DW Parsons, J Hamacher, JL Cooper, KKW Siu, M Donnelley, M Donnelley, M Donnelley, M Donnelley, M Limberis, M Robinson, M Yabashi, P Cloetens, R Tarran, RC Boucher, SH Donaldson, SH Donaldson, ST Ballard, SW Wilkins, XY Hua   +24 more
core   +2 more sources

Cascade‐Responsive MXene@Cu‐MOF Heterostructure Integrates Antioxidant Activity, Infection Control, and Vascularization for Tracheal Repair

Advanced Science, EarlyView.
A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo, Yingran Shen, Jiaoyu Yi, Juanjuan Li, Ziming Wang, Erji Gao, Siqiang Zheng, Zhe‐Sheng Chen, Bo Tao   +8 more
wiley   +1 more source