Results 81 to 90 of about 31,045 (237)

Mucociliary Clearance in Bronchiectasis

An International Journal Clinical Rhinology, 2016
ABSTRACT Bronchiectasis is a chronic lung disease, defined pathologically as irreversible dilatation of the bronchi. There is ineffective clearance of pulmonary secretions because of damage to the cilia. The nasal mucociliary clearance was studied using the saccharine method in 75 patients of bronchiectasis and the results were compared with those of ...
KB Gupta, Jyoti Yadav, Rupender K Ranga, Anuj K Goel   +3 more
openaire   +1 more source

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, EarlyView.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source

Diagnosis of respiratory epithelial clearance abnormality in patients suffering from chemo-resistant pulmonary tuberculosis with comorbidity of bronchial mucosa

Patologìâ, 2018
Respiratory epithelial clearance timely and early disorder diagnosis in patients suffering from chemo-resistant pulmonary tuberculosis (CRPTB) concomitant pathology of the bronchial mucosa is an actual problem of modern phthisiology, the solution of ...
O. M. Raznatovska, V. M. Khlystun
doaj   +1 more source

Multifunctional nanocarriers for lung drug delivery [PDF]

, 2020
Nanocarriers have been increasingly proposed for lung drug delivery applications. The strategy of combining the intrinsic and more general advantages of the nanostructures with specificities that improve the therapeutic outcomes of particular clinical ...
Grenha, Ana, Pontes, Jorge Filipe
core   +2 more sources

Evaluation of Acute Exposure to Combustible and Novel Tobacco Products Using an In Vitro Human Airway Organ Tissue Equivalent Model

Journal of Applied Toxicology, EarlyView.
ABSTRACT Despite the well‐known risks of tobacco use, tobacco exposure remains a major contributor to morbidity and mortality worldwide. Although cigarette use has declined, the popularity of novel tobacco products (NTPs), such as electronic cigarettes (ECs) and heated tobacco products (HTPs), has increased.
Timothy S. Leach, Steven Albertson, Phillip W. Clapp, Vikram Surendran, Trang Simon, Eric C. Donny, Stephen J. Walker, Anthony Atala, Sean V. Murphy   +8 more
wiley   +1 more source

PLACE OF MUKOACTIVE THERAPY OF RINOSINUSITIS IN INTERNATIONAL AND RUSSIAN GUIDELINES

Медицинский совет, 2017
Excessive accumulation of mucous secretions in the nasal cavity and paranasal sinuses is key drivers in the pathogenesis  of rhinosinusitis. Mucoactive drugs are actively used to combat this phenomenon.
S. V. Ryazantsev, S. A. Altushkin, M. A. Budkovaya   +2 more
doaj   +1 more source

Chloride channels regulate differentiation and barrier functions of the mammalian airway. [PDF]

, 2020
The conducting airway forms a protective mucosal barrier and is the primary target of airway disorders. The molecular events required for the formation and function of the airway mucosal barrier, as well as the mechanisms by which barrier dysfunction ...
Caplan, Michael J, Chen, Yuzhang, Darmanis, Spyros, He, Mu, Jan, Lily Yeh, Jan, Yuh Nung, Le, Daniel D, Li, Ke-Xin, Neff, Norma, Padovano, Valeria, Sinclair, Adriane W, Sit, Rene, Tan, Michelle, Wu, Bing, Ye, Wenlei   +14 more
core   +2 more sources

PDCD5 Contributes to Airway Epithelial Cell Damage via Mitochondrial Pathway and Participates in COPD Pathogenesis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Airway epithelial injury plays a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction is implicated in this injury, while the underlying mechanism remains incompletely understood. RNA sequencing was conducted to identify key genes involved in mitochondrial dysfunction in airway epithelial
Hu Shan, Rui Zhang, Yu‐er Li, Rui Li, Shao‐bo Ge, Jin Liu, Shi‐yuan Yao, Xia Yang, Tao Zhang, Ming Zhang   +9 more
wiley   +1 more source

A mechanism of airway injury in an epithelial model of mucociliary clearance

Respiratory Research, 2004
We studied the action of sodium metabisulphite on mucociliary transport in a frog palate epithelial injury model, hypothesizing that it may be useful for the study of mechanisms of airway injury.
O'Brien Darryl W, Morris Melanie I, Ding Jie, Zayas J Gustavo, Tai Shusheng, King Malcolm   +5 more
doaj   +1 more source

Elexacaftor–Tezacaftor–Ivacaftor Reduces Revision Sinus Surgery in People With Cystic Fibrosis

The Laryngoscope, EarlyView.
Elexacaftor–tezacaftor–ivacaftor (ETI) was associated with a significant decrease in the frequency and rate of endoscopic sinus surgeries in patients with cystic fibrosis. These findings suggest an improvement in CF‐related chronic rhinosinusitis outcomes following ETI and may influence future CF treatment decisions.
Amy Lin, Makanko Komara, Isaac Kistler, Zheng Hong Tan, Meredith Lind, Kavitha Kotha, Tendy Chiang   +6 more
wiley   +1 more source