Results 101 to 110 of about 434,754 (278)

Advances in bronchiectasis:endotyping, genetics, microbiome, and disease heterogeneity [PDF]

, 2018
Bronchiectasis is characterised by pathological dilation of the airways. More specifically, the radiographic demonstration of airway enlargement is the common feature of a heterogeneous set of conditions and clinical presentations.
Chalmers, James D., Flume, Patrick A., Olivier, Kenneth N.   +2 more
core   +2 more sources

HYPERTONIC SALINE HAS A PROLONGED EFFECT ON MUCOCILIARY CLEARANCE IN ADULTS WITH CYSTIC FIBROSIS

Journal of Cystic Fibrosis, 2018
Background Inhaled hypertonic saline (HS) has been shown to increase mucociliary clearance (MCC) and improve clinical outcomes in adults and adolescents with cystic fibrosis (CF).
A. Trimble, A. W. Brown, B. Laube, N. Lechtzin, K. Zeman, Jihong Wu, A. Ceppe, D. Waltz, W. Bennett, S. Donaldson   +9 more
semanticscholar   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, EarlyView.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source

PLACE OF MUKOACTIVE THERAPY OF RINOSINUSITIS IN INTERNATIONAL AND RUSSIAN GUIDELINES

Медицинский совет, 2017
Excessive accumulation of mucous secretions in the nasal cavity and paranasal sinuses is key drivers in the pathogenesis  of rhinosinusitis. Mucoactive drugs are actively used to combat this phenomenon.
S. V. Ryazantsev, S. A. Altushkin, M. A. Budkovaya   +2 more
doaj   +1 more source

Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways [PDF]

, 2014
The mechanisms for the development of bronchiectasis and airway hyperreactivity have not been fully elucidated. Although genetic, acquired diseases and environmental influences may play a role, it is also possible that motile cilia can influence this ...
Amria, May, Bell, P. Darwin, Bunni, Marlene A., Estell, Kimberly P., Flume, Patrick, Gilley, Sandra K., Gooz, Monika, Haycraft, Courtney J., Miller, Caroline, Pasek, Raymond C., Pavlik, Jacqueline A., Sas, Kelli M., Schwiebert, Lisa M., Sisson, Joseph H., Steele, Stacy L., Stenbit, Antine E., Turner, Grant A., Yoder, Bradley K.   +17 more
core   +1 more source

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

Respirology, EarlyView.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

A mechanism of airway injury in an epithelial model of mucociliary clearance

Respiratory Research, 2004
We studied the action of sodium metabisulphite on mucociliary transport in a frog palate epithelial injury model, hypothesizing that it may be useful for the study of mechanisms of airway injury.
O'Brien Darryl W, Morris Melanie I, Ding Jie, Zayas J Gustavo, Tai Shusheng, King Malcolm   +5 more
doaj   +1 more source

ciliaFA : a research tool for automated, high-throughput measurement of ciliary beat frequency using freely available software [PDF]

, 2012
Background: Analysis of ciliary function for assessment of patients suspected of primary ciliary dyskinesia (PCD) and for research studies of respiratory and ependymal cilia requires assessment of both ciliary beat pattern and beat frequency.
C O’Callaghan, CL O’Callaghan, CM Smith, CW Wilson, EE Davis, G Mantovani, JH Sisson, JJ Ballenger, JR Kennedy, M Ryser, MA Chilvers, MA Chilvers, RA Hirst, RA Hirst, RA Hirst, S Dimova, TJ Mitchell, WA Stannard, WI Lee, WS Rasband   +19 more
core   +1 more source

Shaping Function: Polymeric 3D Systems With Unconventional Geometries for Biomedical Applications

Small, EarlyView.
Particle shape is a key design parameter governing biological interactions. Advances in fabrication enable precise control over anisotropy and compartmentalization, allowing modulation of cellular uptake, transport, and biodistribution, ultimately enhancing therapeutic performance. ABSTRACT Polymer geometry is a primary determinant of physical behavior
Francisca G. Perfeito, Mariana B. Oliveira, João F. Mano   +2 more
wiley   +1 more source

Assessment of acquired mucociliary clearance defects using micro-optical coherence tomography

International Forum of Allergy and Rhinology, 2017
Dehydration of airway surface liquid (ASL) disrupts normal mucociliary clearance (MCC) in sinonasal epithelium, which may lead to chronic rhinosinusitis (CRS).
Kiranya E. Tipirneni, J. Grayson, Shaoyan Zhang, D. Cho, D. Skinner, D. Lim, Calvin Mackey, Guillermo J. Tearney, S. M. Rowe, B. Woodworth   +9 more
semanticscholar   +1 more source