Results 81 to 90 of about 654,486 (255)

Air Pollution Quinones Impair Intestinal Barrier Integrity and Endoplasmic Reticulum in Differentiated Caco‐2 Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Particulate matter (PM) is a major global health threat, linked to millions of deaths annually. Beyond inhalation, PM components reach the gastrointestinal tract through the mucociliary escalator or contaminated food and water. Among PM's organic fraction, redox‐active quinones such as 1,2‐naphthoquinone (NQ) and 9,10‐phenanthrenequinone (PQ ...
Franco Cervellati, Giulia Trinchera, Alice Casoni, Alessandra Pecorelli, Mascia Benedusi, Maria Chiara Pietrogrande, Giuseppe Valacchi   +6 more
wiley   +1 more source

Evaluating the Local Response of a Novel Injectable Capsule for Drug Delivery in the Trachea

The Laryngoscope, EarlyView.
A novel PLGA polymer capsule was developed for localized pretracheal drug delivery and evaluated for short‐term local tissue safety in a rabbit model. Implant placement was confirmed by ultrasound and was well tolerated over 14 days, with preservation of airway patency, native tracheal architecture, and biomechanical properties.
Denzel Ryan D. Cruz, Nour Awad, Nicholas Russell, Juliana El Sheikh, Logan Obermeyer, Peter J. Larson, Yoonjee C. Park, Gregory R. Dion   +7 more
wiley   +1 more source

Measurement of Nasal Mucociliary Clearance by Saccharin Test [PDF]

, 2013
The nasal mucosa lines the entry of the respiratory tract and is in constant contact with a great variety of inhaled microbial antigens and allergens. Mucociliary clearance is defined as cleaning of upper and lower airway by interaction of nasal mucus ...
Milkov, M.; Faculty of Dental Medicine, Medical University of Varna, Iliev, G.; Medical University of Varna, Eneva, V.; University Hospital „St. Marina“ - Varna, Kerimov, K.; University Hospital „St. Marina“ - Varna, Trajkoski, A.; University Hospital „St. Marina“ - Varna, Nedev, P.; Medical University of Varna, V. Eneva, A. Trajkoski, M. Milkov, G. Iliev, K. Kerimov, P. Nedev   +11 more
core   +1 more source

Dobutamine, Epinephrine, and Milrinone Accelerate Particle Transport Velocity in Murine Tracheal Epithelium via Ca²⁺ Release from Caffeine-Sensitive Internal Stores

Cells
Mucociliary clearance, the ability of the respiratory tract to protect the integrity of the airways through the mechanical removal of potentially harmful substances, is of enormous importance during intensive care treatment.
Götz Schmidt, Frederic Borchers, Sabrina Müller, Amir Ali Akbari, Fabian Edinger, Michael Sander, Christian Koch, Michael Henrich   +7 more
doaj   +1 more source

The Effects of the Anti-aging Protein Klotho on Mucociliary Clearance

Frontiers in Medicine, 2020
α-klotho (KL) is an anti-aging protein and has been shown to exert anti-inflammatory and anti-oxidative effects in the lung and pulmonary diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis.
Jaleesa Garth, Molly Easter, Elex Skylar Harris, Elex Skylar Harris, Juliette Sailland, Lisa Kuenzi, Samuel Chung, Samuel Chung, John S. Dennis, John S. Dennis, Nathalie Baumlin, Nathalie Baumlin, Adegboyega T. Adewale, Steven M. Rowe, Steven M. Rowe, Gwendalyn King, Christian Faul, Jarrod W. Barnes, Jarrod W. Barnes, Matthias Salathe, Matthias Salathe, Stefanie Krick, Stefanie Krick   +22 more
doaj   +1 more source

Tailoring Formulations for Intranasal Nose-to-Brain Delivery: A Review on Architecture, Physico-Chemical Characteristics and Mucociliary Clearance of the Nasal Olfactory Mucosa

Pharmaceutics, 2018
The blood-brain barrier and the blood-cerebrospinal fluid barrier are major obstacles in central nervous system (CNS) drug delivery, since they block most molecules from entering the brain.
Stella Gänger, K. Schindowski
semanticscholar   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Does menopause effect nasal mucociliary clearance time?

, 2015
SIMSEK, GOKCE/0000-0001-5281-0986The aim of this study was to investigate the effect of menopause on nasal mucociliary clearance time by comparing the results of premenopausal and postmenopausal women.
Akkoca, Ayse Neslin, Akbay, Ercan, Ozler, Gul Soylu, Karapinar, Oya Soylu, Simsek, Gokce Ozel, SOYLU ÖZLER, GÜL, Karapınar, Oya Soylu   +6 more
core   +1 more source

Effect of needle puncture and electro-acupuncture on mucociliary clearance in anesthetized quails

BMC Complementary and Alternative Medicine, 2006
Background Acupuncture therapy for obstructive respiratory diseases has been effectively used in clinical practice and the acupuncture points or acupoints of Zhongfu and Tiantu are commonly-used acupoints to treat patients with the diseases.
Wang Tianshan, Xutian Stevenson, Sun Feng, Wang Jiulin, Tai Shusheng, King Malcolm   +5 more
doaj   +1 more source

Association of Nasal Anatomy, Airflow, and Surgery With Olfactory Outcomes: A State‐of‐the‐Art Review

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Olfactory function is influenced by nasal airflow dynamics and anatomical variations within the nasal cavity. This narrative review evaluates how nasal anatomy and airflow relate to olfactory outcomes, with a particular focus on olfactory changes following functional nasal surgery. Data Sources PubMed.
Joshua Ferreira, Alfonso Luca Pendolino, Riccardo Pappalardo, Peter J. Andrews   +3 more
wiley   +1 more source