Results 81 to 90 of about 21,273 (241)

Elevated CO2 and Temperature Alter Grass Pollen's Ability to Modify Transcriptome and Function of the Nasal Epithelium

Allergy, EarlyView.
We exposed human nasal epithelial tissues to pollen from grasses grown under different climate treatments (temperature and CO2). Pollen weakened epithelial tight junctions and altered cytokine‐related gene expression, with similar protein‐level effects.
Tarleena Tossavainen, Tanja Turunen, Maria‐Viola Martikainen, Miisa Kankaanpää, Marjo Malinen, Marjut Roponen   +5 more
wiley   +1 more source

RBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis

Cell Death and Disease
A core pathophysiologic feature underlying many respiratory diseases is multiciliated cell dysfunction, leading to inadequate mucociliary clearance. Due to the prevalence and highly variable etiology of mucociliary dysfunction in respiratory diseases, it
Erik J. Quiroz, Seongjae Kim, Lalit K. Gautam, Zea Borok, Christopher Kintner, Amy L. Ryan   +5 more
doaj   +1 more source

Mucociliary Clearance in Bronchiectasis

An International Journal Clinical Rhinology, 2016
ABSTRACT Bronchiectasis is a chronic lung disease, defined pathologically as irreversible dilatation of the bronchi. There is ineffective clearance of pulmonary secretions because of damage to the cilia. The nasal mucociliary clearance was studied using the saccharine method in 75 patients of bronchiectasis and the results were compared with those of ...
KB Gupta, Jyoti Yadav, Rupender K Ranga, Anuj K Goel   +3 more
openaire   +1 more source

Effect of Dupilumab on Airway Inflammation in Patients With Persistent Asthma

Allergy, EarlyView.
EXPEDITION (NCT02573233) assessed the effects of dupilumab on airway inflammation in patients with persistent asthma using bronchoscopy and gene expression analysis. Dupilumab showed no appreciable effect on inflammatory cell types in biopsies or BALF samples.
Michael E. Wechsler, Sally E. Wenzel, Steve D. Groshong, Mario Castro, Ian D. Pavord, Klaus F. Rabe, Elizabeth Laws, Alexandre Jagerschmidt, Kaitlyn Gayvert, Sivan Harel, Jennifer D. Hamilton, Nikhil Amin, Lu Zhang, Heming Xing, Anissa Elfakir, Bema Coulibaly, Souâd Naimi, Sara Hamon, Paul J. Rowe, Frank Nestle, Danen M. Cunoosamy, Emanuele de Rinaldis, Leda P. Mannent   +22 more
wiley   +1 more source

Mathematical Modeling of Mucociliary Clearance: A Mini-Review

Cells, 2019
Mucociliary clearance is an important innate host defense of the mammalian respiratory system, as it traps foreign substances, including pollutants, pathogens, and allergens, and transports them out of the airway.
Ling Xu, Yi Jiang
doaj   +1 more source

A Novel Device to Improve the Tolerability of Intranasal Corticosteroid Sprays for Allergic Rhinitis and Postoperative Chronic Rhinosinusitis: A Crossover Trial

Clinical Otolaryngology, EarlyView.
ABSTRACT Background Allergic rhinitis (AR) and chronic rhinosinusitis (CRS) are commonly treated with intranasal corticosteroid sprays. Despite their efficacy, unpleasant sensations associated with their application, including post‐nasal drip and nasal irritation, are often cited as reasons for poor compliance.
Sethmi Ranasinghe, Xenia Berger, Wandia Kimita, Kristi Biswas, Raymond Kim, Richard Douglas   +5 more
wiley   +1 more source

A new paradigm in respiratory hygiene: modulating respiratory secretions to contain cough bioaerosol without affecting mucus clearance

BMC Pulmonary Medicine, 2007
Background Several strategies and devices have been designed to protect health care providers from acquiring transmissible respiratory diseases while providing care. In modulating the physical characteristics of the respiratory secretions to minimize the
Bonilla Gloria, Vega Daniel, Alfaro Henry, Alonso Mauricio, Valle Juan C, Zayas Gustavo, Reyes Miguel, King Malcolm   +7 more
doaj   +1 more source

Reconstruction of native cellular microanatomy in a novel bioengineered full thickness human nasal mucosal construct

Journal of Anatomy, EarlyView.
Bioengineered tissue constructs are vital technologies employed in in vitro testing of both fundamental biological principles and industrial screening practices. Current approaches to modelling the nasal mucosa in vitro are not representative and are associated with limitations that impact their reliability and predictive value.
Steven Bradbury, Bethany Dickson, Nicola Curtis, David Bunton, Kirsty Goncalves, Stefan Przyborski   +5 more
wiley   +1 more source

Acute mucociliary clearance response to aerobic exercise in smokers

, 2015
Mucociliary clearance is the main defense mechanism of the respiratory system, and it is influenced by several stimuli, including aerobic exercise and cigarette smoking.
Ramos, Dionei, Cecílio, Michel J., Toledo-Arruda, Alessandra C., Fernandes, Rômulo A. [UNESP], Lima, Fabiano F., Vanderlei, Luiz Carlos M., Fernandes, Rômulo A., Ito, Juliana T., Manzano, Beatriz M., Ramos, Ercy M. C., Ramos, Ercy M. C. [UNESP], Rodrigues, Fernanda Mm   +11 more
core   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source