Results 81 to 90 of about 18,615 (195)

Molecular Docking‐Guided Engineering of TPGS/Tween 80 Mixed Micelles for the Intranasal Delivery of Paliperidone Palmitate

Advanced Therapeutics, Volume 9, Issue 8, August 2026.
A nanoscale drug delivery system is developed to improve how an antipsychotic reaches the brain. Using computer‐guided design, mixed micelles are engineered to enhance drug solubility and nasal transport. The system shows improved release and effectiveness in animal models, reducing symptoms while maintaining brain safety and structure.
Poorva Maske, Rati Kailash Prasad Tripathi, Singdha Das Mandal, Pranav Shah, Nimeet Desai, Manisha Lalan   +5 more
wiley   +1 more source

Uncovering Cystic Fibrosis Carrier: Insights From a Heterozygous CFTR‐F508del Rabbit Model

International Forum of Allergy &Rhinology, Volume 16, Issue 8, Page 788-796, August 2026.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disorder frequently associated with impaired mucociliary clearance and bacterial infection. Individuals carrying a single cystic fibrosis transmembrane conductance regulator (CFTR) mutation exhibit partial CFTR dysfunction and are increasingly recognized as being at risk ...
Do‐Yeon Cho, Alexis E. McFeely, Daniel Skinner, Shaoyan Zhang, Justin Hedvat, Weslee Ping‐ay, Daniel M. Beswick, Justin H. Turner, Bradford A. Woodworth, Jie Xu   +9 more
wiley   +1 more source

Successful Rapid Desensitization to Ceftazidime/Avibactam in a Patient With Cystic Fibrosis and Multidrug‐Resistant Pseudomonas aeruginosa Pneumonia: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Ceftazidime/avibactam (CAZ‐AVI) is an important therapeutic option for multidrug‐resistant (MDR) Pseudomonas aeruginosa infections; however, hypersensitivity reactions may preclude its use and create significant therapeutic challenges. We report a 21‐year‐old woman with cystic fibrosis and recurrent MDR P.
Zuoren Zhou, Jinqi Zhu, Ge Wu, Xi Kang, Qing Wang, Jie Liu, Yan Jiang   +6 more
wiley   +1 more source

Acute Exacerbation of Chronic Obstructive Pulmonary Disease Immediately After Extubation Following Percutaneous Nephrolithotomy: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT In patients with moderate‐to‐severe COPD, short‐term (1‐day) preoperative respiratory optimization may be insufficient to prevent acute exacerbation after extubation. Prolonged preoperative preparation, meticulous intraoperative lung‐protective ventilation, and a post‐extubation rapid‐response protocol are essential.
Mengyue Gu, Sen Yan, Ruiliang Wang, Fujun Zhang, Tianyao Zhang, Hui Zhong   +5 more
wiley   +1 more source

The impact of topically applied preservation solutions on the respiratory epithelium of tracheal grafts submitted to cold ischemia: functional and morphological analysis

Clinics, 2013
OBJECTIVE: Advances in graft reepithelialization and revascularization have renewed interest in airway transplantation. This study aims to determine whether topically applied preservation solutions can ameliorate ischemic injury to tracheal grafts.
Artur Eugênio de Azevedo-Pereira, Juliana Akemi Saka, Karina Andrighetti de Oliveira-Braga, Rogério Pazetti, Mauro Canzian, Paulo Manuel Pêgo-Fernandes, Fabio Biscegli Jatene   +6 more
doaj  

Polymicrobial Extracellular Vesicles Reduce the Innate Immune Response of Human Cystic Fibrosis Bronchial Epithelial Cells

Journal of Extracellular Biology, Volume 5, Issue 8, August 2026.
ABSTRACT Chronic antibiotic‐resistant cystic fibrosis (CF) lung infections are the leading cause of death in adults with CF. Despite advances in highly effective modulator therapies, microbial communities persist in the CF lung. The pathogenesis of CF airway infections can be exacerbated by pathogens such as Pseudomonas aeruginosa, which communicates ...
Lily A. Charpentier, Roxanna L. Barnaby, Carolyn T. Roche, Byoung‐Kyu Cho, Prashant Kaushal, Young Ah Goo, Brad Vietje, Douglas J. Taatjes, Alix Ashare, Fabrice Jean‐Pierre, Bruce A. Stanton   +10 more
wiley   +1 more source

Diesel exhaust particle exposure exacerbates ciliary and epithelial barrier dysfunction in the multiciliated bronchial epithelium models

Ecotoxicology and Environmental Safety
Airway epithelium, the first defense barrier of the respiratory system, facilitates mucociliary clearance against inflammatory stimuli, such as pathogens and particulates inhaled into the airway and lung.
Eunsook Park, Bu-Yeo Kim, Seahyoung Lee, Kuk Hui Son, Jihye Bang, Se Hyang Hong, Joong Won Lee, Kyung-Ok Uhm, Hyun-Jeong Kwak, Hyun Joung Lim   +9 more
doaj   +1 more source

Sinonasal Inflammatory Burden on Computed Tomography in Adults With Obstructive Eustachian Tube Dysfunction: A Case–Control Study

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 4, August 2026.
ABSTRACT Introduction Chronic rhinosinusitis (CRS) and Eustachian tube dysfunction (ETD) frequently coexist, yet objective data quantifying their relationship remain scarce. Because both conditions can reflect shared mucosal inflammation, we investigated whether adults with objectively verified ETD harbor a larger paranasal sinus inflammatory burden on
Dachan Kim, Jeong Gum Lee, Seong Hoon Bae   +2 more
wiley   +1 more source

Management of Primary Ciliary Dyskinesia in a Kartagener's Syndrome Patient With Total Situs Inversus

Respirology Case Reports
Kartagener's syndrome is a rare, autosomal recessive disorder characterised by primary ciliary dyskinesia (PCD) resulting in impaired mucociliary clearance and situs inversus.
Ivan H. Huang, Kenneth N. Dang, Saarang Kashyap, Alexander J. Sweidan   +3 more
doaj   +1 more source

Adverse Events of Tracheobronchial Stents: A MAUDE Database Study With Focus on Metallic Stents

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 4, August 2026.
ABSTRACT Objectives Tracheobronchial stents treat conditions that reduce airflow such as malignancy, tracheomalacia, and stenosis, but may fail and cause complications. This study aims to use the US Food and Drug Administration Manufacturer and User Facility Device Experience (MAUDE) database to understand adverse events related to tracheobronchial ...
Janvi J. Shukla, Nicholas S. Hamilton, Sraavya Anne, Kenneth Yan, Rachel Kaye   +4 more
wiley   +1 more source