Results 121 to 130 of about 21,273 (241)

Multi‐Layered Genomic and Clinical Analysis Identifies Novel Variants, Co‐Occurring Single Nucleotide Polymorphism Pairs, and Clinical Determinants of Host‐Pathogen Interaction in COVID‐19 Severity

Journal of Medical Virology, Volume 98, Issue 6, June 2026.
ABSTRACT Host genetic factors may contribute to COVID‐19 severity. To identify genetic variants influencing COVID‐19 severity progression, whole‐exome sequencing was performed, followed by an exome‐wide association study on 191 hospitalized patients categorized into three severity groups.
Doris Repušić, Marina Korolija, Ana Livun, Tomo Svaguša, Robert Belužić, Vjekoslav Tomaić, Rosa Karlić, Kristian Vlahoviček   +7 more
wiley   +1 more source

Studies of mucociliary clearance, cough and forced expiration in patients with lung disease [PDF]

, 1994
Mucociliary clearance is one of the lungs' non-specific host defence mechanisms and together with cough helps to keep the conducting airways clean even when exposed to a polluted atmosphere.
Hasani, Amer Hasan
core  

High Versus Low Radiographic Burden Odontogenic Sinusitis: Culture, Histopathology, and Patient‐Reported Outcomes

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 3, June 2026.
This study investigated clinical, histopathologic, and symptomatic differences between odontogenic sinusitis patients with high versus low radiographic burden. High radiographic burden disease was associated with older age and increased tissue inflammation, while significant postoperative symptom improvement was only observed in the high‐burden cohort.
Landon E. Ebbert, Nitish Kumar, Devyani Lal, Amar Miglani, Michael J. Marino   +4 more
wiley   +1 more source

Airway Mucus Hypersecretion in Chronic Obstructive Pulmonary Disease Patients: From Basic Pathophysiology to Rehabilitation Approaches

Surabaya Physical Medicine and Rehabilitation Journal
Objective: This narrative review aimed to describe the pathophysiology of mucus accumulation and mucus expectoration disorders, rehabilitation assessments, and airway clearance techniques in chronic obstructive pulmonary disease (COPD) patients ...
Arnengsih Nazir, Brandon Clementius
doaj   +1 more source

Viral Detection and Clinical Disease Features in Pediatric Chronic Rhinosinusitis

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 3, June 2026.
ABSTRACT Objectives Chronic rhinosinusitis (CRS) results from complex host‐environment interactions with microbiome dysbiosis and viral infections postulated to drive inflammation and anatomic remodeling. This study investigates the impact of viral presence on pediatric sinonasal disease and clinical outcomes.
Mary C. Wilding, Amber D. Shaffer, Glenn J. Rapsinski, Monika Johnson, Yasmin Hilliam, John V. Williams, Jennifer M. Bomberger, Amanda L. Stapleton   +7 more
wiley   +1 more source

Effects of rapid maxillary expansion on nasal mucociliary clearance

, 2016
Objective: To evaluate the changes in nasal mucociliary clearance in orthodontic patients after rapid maxillary expansion (RME) therapy. Materials and Methods: Forty-two children (25 boys and 17 girls) participated in this study.
Uysal, I.O., Babacan, Hasan, Uysal, Ismail Onder, Yuce, S., Doruk, C., Doruk, Cenk, Yuce, Salim   +6 more
core   +1 more source

Lung Microbiome Diversity, Infection Dynamics, and Microbe‐Mediated Cross‐Protection

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The protective role of the lung microbiome in maintaining respiratory health by promoting immune homeostasis, pathogen exclusion, and barrier integrity. Diverse microbial communities regulate immune maturation, enhance epithelial defenses, and contribute to antiviral responses, collectively preventing pathogen colonization and sustaining a balanced ...
Sana Arooj, Akmal Zubair, Syeda Zaira Batool, Granaz Niaz, Muhammad Ali, Yasir Waheed, Eman Ramadan Elsharkawy, Naila Afghan   +7 more
wiley   +1 more source

Model of mucociliary clearance in cystic fibrosis lungs.

, 2015
Mucus clearance is a primary innate defense mechanism in the human airways. Cystic fibrosis (CF) is a genetic disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein.
Bessonov, N, Caudri, D, Fisch, Roland, Bajard, Agathe, Cornu, C, Ogungbenro, Kayode; id_orcid, Bretz, Frank, Alberti, Corinne, Jullien, Vincent, Wendling, Fabrice, Bertrand, Yves, Kassai, Behrouz, Nony, Patrice, Kurbatova, P, Volpert, V, Pons, Gérard, Nony, P, Chiron, Catherine, Tiddens, H A W M, Pérol, David, Aarons, Leon; id_orcid, Malik, Salma, Benquet, Pascal, Chabaud, Sylvie, Guerrini, Renzo, Tiddens, Harm, Eymard, Nathalie, Nabbout, Rima, Cornu, Catherine, Dufour, Frank, Castellan, Charlotte, Kurbatova, Polina, Rosati, Anna   +32 more
core   +1 more source

Preclinical Quantitative In Vivo MRI Assessment of Exogenous Surfactant Pulmonary Distribution After Clinically Relevant Intratracheal Delivery

NMR in Biomedicine, Volume 39, Issue 6, June 2026.
Quantitative in vivo contrast‐enhanced UTE MRI enables sensitive and precise mapping of pulmonary surfactant distribution, revealing peripheral localization and homogeneous distal penetration under physiological conditions. Comparison with ex vivo models highlights the role of physiological processes in surfactant retention.
Oumaima Marfouk, Rémy Gérard, Ghalia Kaouane, Lara Leclerc, Noël Pinaud, Michael Fayon, Sophie Périnel‐Ragey, Jérémie Pourchez, Eric Dumas De La Roque, Yannick Crémillieux   +9 more
wiley   +1 more source

Effect of salmeterol xinafoate on lung mucociliary clearance in patients with asthma

, 2003
Lung mucociliary clearance is impaired in stable asthma. The long-acting β2-agonist salmeterol has been shown in vitro to cause a significant increase in ciliary beat frequency.
HASANI, A., DILWORTH, J.P., O'CONNOR, J., AGNEW, J.E., TOMS, N.   +4 more
core   +1 more source