Results 121 to 130 of about 654,486 (255)

Assessment of acquired mucociliary clearance defects using micro-optical coherence tomography

International Forum of Allergy and Rhinology, 2017
Dehydration of airway surface liquid (ASL) disrupts normal mucociliary clearance (MCC) in sinonasal epithelium, which may lead to chronic rhinosinusitis (CRS).
Kiranya E. Tipirneni, J. Grayson, Shao-Yan Zhang, D. Cho, D. Skinner, D. Lim, Calvin Mackey, G. J. Tearney, S. M. Rowe, B. Woodworth   +9 more
semanticscholar   +1 more source

The discovery and development of ensifentrine: A novel inhaled dual PDE3/4 inhibitor having ‘bifunctional’ bronchodilator and anti‐inflammatory activity

British Journal of Pharmacology, EarlyView.
Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley   +1 more source

Long Non‐Coding RNA, Like NEAT1 and MALAT1, in Asthma: Mechanisms and Therapeutic Potential

Clinical &Experimental Allergy, EarlyView.
Long non‐coding RNA, like NEAT1 and MALAT1, is emerging as a regulator of asthma‐related inflammation, airway remodelling, viral responses and cell death pathways, and are promising targets for future therapeutics. ABSTRACT Asthma affects millions worldwide. Long non‐coding RNA (lncRNA) are emerging as important factors in the pathophysiology of asthma
Ashlyn Poole, Ingrid Laing, Ryan Mead‐Hunter, Peter Le Souef, Guicheng Zhang   +4 more
wiley   +1 more source

RBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis

Cell Death and Disease
A core pathophysiologic feature underlying many respiratory diseases is multiciliated cell dysfunction, leading to inadequate mucociliary clearance. Due to the prevalence and highly variable etiology of mucociliary dysfunction in respiratory diseases, it
Erik J. Quiroz, Seongjae Kim, Lalit K. Gautam, Zea Borok, Christopher Kintner, Amy L. Ryan   +5 more
doaj   +1 more source

Low Allergic Sensitisation in Wheezing Children With Down Syndrome: A Case–Control Study

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Respiratory disorders are frequent in children with Down syndrome (DS), causing prolonged hospitalisations and increased healthcare system costs. Among these, recurrent wheezing is common in these children despite indications of lower rates of allergic sensitisation and asthma.
Francylene Malheiros Macedo da Cunha Rego, Geórgia Veras de Araújo Gueiros Lira, Emanuel Sávio Cavalcanti Sarinho, Patricia Gomes de Matos Bezerra, Marcilio Lins Aroucha, Igor Gabriel Araujo Medeiros, Decio Medeiros Peixoto   +6 more
wiley   +1 more source

Reduced mucociliary clearance in old mice is associated with a decrease in Muc5b mucin.

American Journal of Physiology - Lung cellular and Molecular Physiology, 2016
Respiratory infections are a major cause of morbidity and mortality in the elderly. Previous reports have suggested that mucociliary clearance (MCC) is impaired in older individuals, but the cause is unclear. To unravel the mechanisms responsible for the
B. R. Grubb, A. Livraghi-Butrico, T. D. Rogers, W. Yin, B. Button, L. Ostrowski   +5 more
semanticscholar   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Oral Health, Periodontitis, and Respiratory Diseases: Biological Pathways

Journal of Periodontal Research, EarlyView.
This narrative review aims to provide a comprehensive update on the potential mechanisms by which poor oral health and periodontitis impact lung health, focusing on pneumonia, COPD, and asthma. ABSTRACT Poor oral hygiene and periodontitis influence lung diseases such as pneumonia, chronic obstructive pulmonary disease (COPD), COVID‐19, and asthma.
Raluca P. Vacaru, Andreea C. Didilescu, Frank A. Scannapieco   +2 more
wiley   +1 more source

Early effect of exogenous Na hyaluronate on mucociliary clearance

, 2005
Background: An animal study is performed to determine the early effect of 1% Na hyaluronate on mucociliary clearance function. Methods: One percent of Na hyaluronate was introduced into the maxillary sinuses of rabbits by anterior antrostomy.
Gumus, C, Kocaturk, S, Turgut, B, Kunt, T, Yildirim, A, Bebek, AI, Turgut, Bulent, Bebek, Ali Ihsan, Gumus, Cesur, Kunt, Tanfer, Kocaturk, SİNAN, Yildirim, Altan   +11 more
core   +1 more source

A new paradigm in respiratory hygiene: modulating respiratory secretions to contain cough bioaerosol without affecting mucus clearance

BMC Pulmonary Medicine, 2007
Background Several strategies and devices have been designed to protect health care providers from acquiring transmissible respiratory diseases while providing care. In modulating the physical characteristics of the respiratory secretions to minimize the
Bonilla Gloria, Vega Daniel, Alfaro Henry, Alonso Mauricio, Valle Juan C, Zayas Gustavo, Reyes Miguel, King Malcolm   +7 more
doaj   +1 more source