Mucorales Species and Macrophages [PDF]
Journal of Fungi, 2020 Mucormycosis is an emerging fungal infection caused by Mucorales with an unacceptable high mortality rate. Mucorales is a complex fungal group, including eleven different genera that can infect humans.
Francisco E. Nicolás +5 more
doaj +7 more sources
Development and evaluation of a Pan-Mucorales Real-time PCR and a multiplex Real-time PCR for detection and identification of <i>Rhizopus arrhizus, Rhizopus microsporus</i>, and <i>Mucor</i> spp. in clinical specimens. [PDF]
J Clin MicrobiolMucormycosis is a life-threatening infection associated with high morbidity and mortality. Rapid and accurate diagnosis is essential for improving patient outcomes.
Tang HM +3 more
europepmc +3 more sources
Mucorales fungi suppress nitric oxide production by macrophages
mBio, 2023 Mucormycosis is classified by the National Institute of Allergy and Infectious Diseases as an emerging disease and is caused by Mucorales fungi. Despite the high morbidity and mortality rates associated with the disease, little is known about the host ...
Alexandra Y. Soare, Vincent M. Bruno
doaj +2 more sources
Mucorales and Mucormycosis: Recent Insights and Future Prospects
Journal of Fungi, 2023 The classification of Mucorales encompasses a collection of basal fungi that have traditionally demonstrated an aversion to modern genetic manipulation techniques.
Ghizlane Tahiri +7 more
doaj +2 more sources
Frontiers in Cellular and Infection Microbiology, 2022 IntroductionSerum Mucorales PCR can precede the final diagnosis of invasive mucormycosis by several days or weeks and could therefore be useful as a non-invasive screening tool.MethodsWe assessed the performance of a commercial Mucorales PCR assay ...
Robina Aerts +8 more
doaj +2 more sources
Antifungal activity of Taurolidine against Mucorales: An in vitro study on clinical isolates [PDF]
Current Medical Mycology, 2022 Background and Purpose: Taurolidine is active against a wide variety of micro organisms, including bacteria and fungi. Mucormycosis is one of the life-threatening opportunistic fungal infections, especially in immunocompromised patients.
Hadis Jafarian +2 more
doaj +2 more sources
A Clustered Case Series of Mucorales Detection in Respiratory Samples from COVID-19 Patients in Intensive Care, France, August to September 2021 [PDF]
Journal of Fungi, 2022 While COVID-19-associated pulmonary aspergillosis is now well described in developed countries, COVID-19-associated mucormycosis (CAM) has seemed to remain quite rare in Europe.
Emilie Guémas +9 more
semanticscholar +2 more sources
Frontiers in Cellular and Infection Microbiology, 2023 BackgroundIn this study, we used real-time quantitative PCR (RQ-PCR) to rapidly detect Mucorales and Aspergillus in formalin-fixed, paraffin-embedded (FFPE) samples, targeting 18SrRNA gene and 28SrRNA gene. Identification of Mucorales and Aspergillus was
Xiaolin Jiang +3 more
doaj +2 more sources
PLoS ONE, 2023 Olorofim is a new antifungal in clinical development which has a novel mechanism of action against dihydroorotate dehydrogenase (DHODH). DHODH form a ubiquitous family of enzymes in the de novo pyrimidine biosynthetic pathway and are split into class 1A,
Corinne Pinder +4 more
semanticscholar +3 more sources
Antifungal Activity of Isavuconazole and Comparator Agents against Contemporaneous Mucorales Isolates from USA, Europe, and Asia-Pacific [PDF]
Journal of Fungi, 2023 Isavuconazole is the only US FDA-approved antifungal for treating invasive mucormycosis. We evaluated isavuconazole activity against a global collection of Mucorales isolates.
C. Carvalhaes +4 more
semanticscholar +2 more sources