Results 91 to 100 of about 244,081 (296)

Porcine Circovirus Type 2 Induces Single Immunoglobulin Interleukin-1 Related Receptor (SIGIRR) Downregulation to Promote Interleukin-1β Upregulation in Porcine Alveolar Macrophage

Viruses, 2019
Multisystemic inflammation in pigs affected by porcine circovirus type 2 (PCV2) indicates the disordered expression of inflammatory cytokines. However, the PCV2-induced expression profile of inflammation cytokines and its regulating mechanism remain ...
Shunli Yang, Baohong Liu, Shuanghui Yin, Youjun Shang, Xinming Zhang, Muhammad Umar Zafar Khan, Xiangtao Liu, Jianping Cai   +7 more
doaj   +1 more source

State-of-the-art in the pneumococcal field: Proceedings of the 11th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-11)

Pneumonia, 2020
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) is the premier global scientific symposium dedicated to the exchange, advancement and dissemination of the latest research on the pneumococcus, one of the world’s deadliest ...
Brenda Anna Kwambana-Adams, E. Kim Mulholland, Catherine Satzke, ISPPD group   +3 more
doaj   +1 more source

Dual‐Functional Ingestible Passive Capsules for High‐Throughput Intestinal Sampling with Sealed Containment and Targeted Drug Delivery

Advanced Robotics Research, EarlyView.
To address challenges in high‐throughput intestinal sampling with sealed containment and target drug delivery, we developed a dual‐functional ingestible passive capsule with a dual‐triggered control system based on pH‐response and mechanical actuation.
Libing Huang, Houyu Ling, Xizong Chen, Yufei Duan, Yu Liu, Shuntian Cai, Yandan Ren, Wenlong Li, Lei Ren, Miao Wang   +9 more
wiley   +1 more source

Respiratory antiviral immunity and immunobiotics: Beneficial effects on inflammation-coagulation interaction during influenza virus infection [PDF]

, 2016
Influenza virus (IFV) is a major respiratory pathogen of global importance, and the cause of a high degree of morbidity and mortality, especially in high-risk populations such as infants, elderly, and immunocompromised hosts.
Alvarez, Gladis Susana, Kitazawa, Haruki, Villena, Julio Cesar, Zelaya, María Hortensia del Rosario   +3 more
core   +1 more source

IL‐3 Modulates Microglia Polarization and Attenuates Neuroinflammation in Traumatic Brain Injury

Advanced Science, EarlyView.
IL‐3 recruits PRDX1 through IL‐3R to modulate the inflammatory response of microglia via the KEAP1‐NRF2‐HO‐1/NF‐κB pathway to attenuate neuroinflammation in traumatic brain injury. ABSTRACT Microglia play a crucial role in the progression of neuroinflammation following traumatic brain injury (TBI). Interleukin‐3 (IL‐3), a significant regulatory factor,
Nana Huang, Qingchen Zhang, Yanrui Chen, Dapeng Yu, Ronghan Liu, Jianning Kang, Xiang Fang, Ying Zhang, Hong Bian, Yanxin Zhao, Yongcheng Yin, Ce Zhang, Yanfei Jia, Qingfa Chen, Yuepeng Fang, Shang Li, Fang Li, Zhengxin Jin, Bin Ning   +18 more
wiley   +1 more source

Protective Microbiota: From Localized to Long-Reaching Co-Immunity [PDF]

, 2017
Resident microbiota do not just shape host immunity, they can also contribute to host protection against pathogens and infectious diseases. Previous reviews of the protective roles of the microbiota have focused exclusively on colonization resistance ...
Abt, Abt, Algburi, Altenhoefer, Altier, Anderson, Annuk, Asahara, Ashburner, Ayabe, Ayres, Barr, Barton, Bassis, Bassler, Becattini, Belkaid, Belkaid, Belkaid, Belkaid, Benson, Benveniste, Berg, Bevins, Birchenough, Birchenough, Blackburn, Bocci, Bohnhoff, Botes, Bouskra, Brandl, Braniste, Brenchley, Brestoff, Britton, Bron, Brugiroux, Budden, Buddington, Buffie, Buffie, Cani, Cani, Carey, Cash, Castagliuolo, Catford, Cebra, Cerf-Bensussan, Chatzidaki-Livanis, Chen, Chow, Chudnovskiy, Clarke, Clarke, Clarke, Cogen, Cogen, Cogen, Cotar, Cremer, Crost, Danielsson, Davidson, Davis, de Agüero, de Sablet, de Steenhuijsen Piters, Delhaes, Denny, Deriu, Dickson, Dickson, Dickson, Dickson, Donaldson, Donnet-Hughes, Eberl, El-Solh, Everett, Fagundes, Fardini, Fine, Fransen, Frantz, Franzenburg, Freter, Freter, Freter, Freter, Freter, Fubara, Fukuda, Gabryszewski, Gallichan, Gallo, Ganal, Gantois, Gauguet, Geva-Zatorsky, Gill, Gorjifard, Gutzeit, Henao-Mejia, Hersoug, Hibbing, Hooper, Hooper, Hooper, Hsiao, Ichinohe, Irie, Ivanov, Ivanov, Iwase, Kamada, Khosravi, Kinnunen, Knoop, Koch, Kolling, Kommineni, Laurent, Lawley, Levine, Little, Mack, Macpherson, Macpherson, Macpherson, Macpherson, Majlessi, Mallon, Maltby, Man, Mantis, Martins, Masson, Mazmanian, Mazmanian, McAleer, McKenney, Medzhitov, Melo, Mishra, Molloy, Murall, Mushin, Nagy, Nikkari, Oldroyd, Olier, Palm, Pamer, Pang, Perry, Pfeiffer, Pontier-Bres, Pradeu, Pradeu, Pradeu, Pérez-Santiago, Qin, Ramanan, Rasmussen, Rea, Rea, Ripert, Rizzetto, Robinson, Rolfe, Roossinck, Round, Ruhe, Råberg, Salzman, Sambanthamoorthy, Samuelson, Santagati, Santagati, Sassone-Corsi, Sassone-Corsi, Savage, Schamberger, Schieber, Schneider, Schuijt, Sharma, Shi, Shin, Shokouhfard, Shu, Siegrist, Soares, Sommer, Spees, Stapleton, Stappenbeck, Stecher, Stecher, Stinson, Strugnell, Sutyak Noll, Tanaka, Theriot, Tillmann, Tomkovich, Tomás, Tuomola, Ubeda, Underhill, Vaishnava, Valdés-Varela, Valdés-Varela, Valle, Van de Perre, van der Waaij, Vandecandelaere, Venkataraman, Villarino, Virgin, Virgin, Walker, Walsham, Weaver, Weingarden, Wexler, Whiteson, Wikoff, Willis, Wootton, Wright, Wu, Xiang, Yilmaz, Zagato, Zeng, Zipperer   +238 more
core   +4 more sources

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Mucosal IL-4R antagonist HIV vaccination with SOSIP-gp140 booster can induce high-quality cytotoxic CD4+/CD8+ T cells and humoral responses in macaques

Scientific Reports, 2020
Inducing humoral, cellular and mucosal immunity is likely to improve the effectiveness of HIV-1 vaccine strategies. Here, we tested a vaccine regimen in pigtail macaques using an intranasal (i.n.) recombinant Fowl Pox Virus (FPV)-gag pol env-IL-4R ...
Z. Li, M. Khanna, S. L. Grimley, P. Ellenberg, C. A. Gonelli, Wen Shi Lee, T. H. Amarasena, A. D. Kelleher, D. F. J. Purcell, S. J. Kent, C. Ranasinghe   +10 more
doaj   +1 more source

Calcitonin receptor-like receptor is expressed on gastrointestinal immune cells [PDF]

, 2002
Background/Aims: Pharmacological and morphological studies suggest that the gut mucosal immune system and local neuropeptide-containing neurones interact.
Göke, B., Haberberger, R., Hagner, S., Knauer, J., McGregor, G. P., Voigt, K.   +5 more
core   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source