Results 111 to 120 of about 48,706 (299)

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Mucosal Immunity/Mucosal Vaccine

Nippon Shokuhin Kagaku Kogaku Kaishi, 2009
ヒトや動物には，外敵から身体を守るために免疫系が備わっている．多くのウイルスや病原菌の侵入口である粘膜面には効果的な「粘膜免疫」が存在し，抗原特異的分泌型IgA応答や細胞障害性T細胞（CTL）を誘導する．各粘膜は共通粘膜免疫機構（common mucosal immune system（CMIS））により関連をもち，ある粘膜組織で誘導されたIgA産生細胞やCTLは他の粘膜組織にも帰巣（ホーミング）する．とくに，分泌型IgA産生細胞は，腸管関連リンパ組織（GALT），鼻咽頭関連リンパ組織（NALT）および気管支関連リンパ組織（BALT）などの誘導組織（inductive site）で誘導され，実効組織（effector site）である腸管粘膜固有層，呼吸器粘膜固有層，乳腺，涙腺，唾液腺 ...
openaire   +2 more sources

Attitudes Toward Prenatal Interventions in the Fanconi Anemia Community

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective In‐utero cell and gene therapies may offer prenatal treatment options for inherited diseases. Preclinical data suggests in‐utero (IU) hematopoietic stem cell transplantation (HSCT) could prevent Fanconi anemia (FA) related bone marrow failure without genotoxic conditioning or immune suppression.
Tony Lum, Catherine Lee, Tippi MacKenzie, Billie Lianoglou, Agnieszka Czechowicz   +4 more
wiley   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Facility Type Predicts Treatment Regimen for Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives Treatment landscapes are changing for HPV+ oropharyngeal cancer (OPC) without compromising oncologic outcomes. We aim to analyze treatment trends of HPV+ OPC at academic (ACs) and nonacademic centers (NACs). Methods The National Cancer Database was queried, and multinomial logistic regression was used to predict treatment trends ...
Monica S. Trent, Kelsey Roman, Timothy I. Hsu, Yarah M. Haidar, Tjoson Tjoa   +4 more
wiley   +1 more source

Nutrition and Gut Mucositis in Pediatric Oncology [PDF]

, 2015
Childhood malignancies are the second most common cause of death in children. A major limitation of current therapies is the high toxicity. Alimentary tract toxicity (mucositis) is associated with increased risk of complication such as infections that ...
Pontoppidan, Peter Erik Lotko
core  

Timing for Radiotherapy Initiation After Dental Extraction and Risk of Osteoradionecrosis in Head and Neck Cancer Patients: A Systematic Review and Meta‐Analysis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Head and neck cancer (HNC) patients are advised to undergo dental extraction of teeth with poor prognosis prior to radiotherapy (RT) initiation to prevent osteoradionecrosis (ORN). However, insufficient healing time may result in persistent extraction wounds during RT, which constitute a potential risk factor for ORN, whereas ...
Nuo‐Zhou Liu, Yi‐Xuan Liu, Zhe Li, Jun Ma, Na Liu   +4 more
wiley   +1 more source

Clinical validation of the nursing diagnosis of inadequate nutritional intake in children with cancer

International Journal of Nursing Knowledge, EarlyView.
Abstract Purpose To clinically validate the nursing diagnosis “Inadequate Nutritional Intake” based on elements identified within a specific situation theory framework in the context of children with cancer. Methods This is a diagnostic accuracy study following the Standards for Reporting Diagnostic Accuracy Studies (STARD) protocol.
Iane Ximenes Teixeira, Natália Cabrera Matos, Marcos Venícios de Oliveira Lopes, Viviane Martins da Silva, Amanda Laryssa Gomes do Nascimento, Yanka Alcântara Cavalcante, Ana Beatriz Oliveira Marques dos Santos, Daniele Paula Alves Mouta   +7 more
wiley   +1 more source

The Australian and New Zealand Dental Implant Registry: Regulatory Requirements and Registry Development

Australian Dental Journal, EarlyView.
ABSTRACT Background The Therapeutic Goods Administration is responsible for the Regulation of manufacture and supply of all medical devices including dental implants. Medically, the patient is given a ‘Patient Implant Card’ (PIC). It is recommended to monitor the performance of devices in an implant registry.
S. Soukoulis, S. Davis, A. Goss
wiley   +1 more source

Hepcidin promotes oral ulcer healing via amphiregulin production in rats

Journal of Dental Sciences
Background/purpose: Hepcidin is an antimicrobial peptide that regulates iron metabolism. Recently, hepcidin was reported to promote wound healing. However, the mechanism underlying hepcidin signaling in the oral mucosa remains unclear.
Naoto Taguchi, Suzuro Hitomi, Hitoshi Sato, Yoshinori Hayashi, Ikuko Shibuta, Koichi Iwata, Tatsuo Shirota, Masamichi Shinoda   +7 more
doaj   +1 more source