Results 11 to 20 of about 2,119 (184)
Citrus Flavonoids for Cystic Fibrosis Treatment. [PDF]
ChembiochemStudies conducted since the late 1990s show substantial activity of selected citrus flavonoids as cystic fibrosis transmembrane conductance regulator (CFTR) membrane protein activators. The thesis of this work is that aptly formulated citrus flavonoids hold sigificant potential for developing a multitarget treatment of cystic fibrosis combining in a ...
Pagliaro M +5 more
europepmc +2 more sources
Distinct Roles of SLC26A3 and CFTR in Surface pH Regulation and Bicarbonate Secretion in Human Intestinal Epithelium. [PDF]
Acta Physiol (Oxf)ABSTRACT Background and Aims Colonic bicarbonate secretion is mediated by the chloride/bicarbonate exchanger SLC26A3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Dysfunction of either causes luminal acidosis, altered mucus properties, and inflammation.
Amiri M, Salari A, Seidler U.
europepmc +2 more sources
Ethics Committees' Practices in Healthcare, Banking and Research: Key Requirements for Their Functionality. [PDF]
J Eval Clin PractABSTRACT Rationale To meet concerns about ethical and unethical behavior in their work environments and workplaces, organizations began establishing ethics programs that contain ethics committees (ECs). There is now a tradition and diverse use of ECs for ethical decision‐making in many different organizational settings.
Arık T, Michl S.
europepmc +2 more sources
Medical Journal of Australia, Volume 219, Issue 10, Page 496-502, November 2023., 2023 Summary Cystic fibrosis is a monogenic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein, which transports chloride ions in secretory organs. Modulator therapies are small molecules that correct CFTR dysfunction and can lead to a wide range of benefits for both pulmonary and extrapulmonary ...
Shanal Kumar +3 more
wiley +1 more source
Measurement of Trogocytosis: Quantitative Analyses Validated with Rigorous Controls
Current Protocols, Volume 3, Issue 10, October 2023., 2023 Abstract Trogocytosis is a process in which receptors on acceptor cells remove and internalize cognate ligands from donor cells. Trogocytosis has a profound and negative impact on mAb‐based cancer immunotherapy, as seen in the treatment of chronic lymphocytic leukemia (CLL) with CD20 mAbs, such as rituximab (RTX) and ofatumumab (OFA).
Ronald P. Taylor, Margaret A. Lindorfer
wiley +1 more source
Spatial Single Cell Analysis of Proteins in 2D Human Gastruloids Using Iterative Immunofluorescence
Current Protocols, Volume 3, Issue 10, October 2023., 2023 Abstract During development, cell signaling instructs tissue patterning, the process by which initially identical cells give rise to spatially organized structures consisting of different cell types. How multiple signals combinatorially instruct fate in space and time remains poorly understood.
Emily Freeburne +7 more
wiley +1 more source
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 43, Issue 8, Page 740-777, August 2023., 2023 Abstract Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well established to display time‐dependent bactericidal activity, where reductions in bacterial burden are directly associated with the time that free drug ...
Lisa T. Hong +16 more
wiley +1 more source
Isolation of Adult Mouse Cardiac Fibroblasts
Current Protocols, Volume 3, Issue 7, July 2023., 2023 Abstract Fibroblasts are dynamic cells of mesenchymal origin that regulate tissue homeostasis, extracellular matrix production, and acute wound healing. Fibroblasts respond to tissue injury and inflammation by differentiating into myofibroblasts and secreting extracellular matrix proteins.
Abir Almazloum, Hadi Khalil
wiley +1 more source
Chemosensory cells in the respiratory tract as crucial regulators of innate immune responses
The Journal of Physiology, Volume 601, Issue 9, Page 1555-1572, 1 May 2023., 2023 Abstract figure legend Chemosensory cells that are characterised by the expression of a functional bitter taste signalling cascade are widely expressed in tissues outside of taste buds in the tongue. In the respiratory system they are known under diverse names: microvillous cells in the main olfactory epithelium, solitary chemosensory cells in the ...
Monika I. Hollenhorst +1 more
wiley +1 more source
Overview of Genotyping Technologies and Methods
Current Protocols, Volume 3, Issue 4, April 2023., 2023 Abstract Genetics is a cornerstone of molecular biology, and there have been significant developments in genotyping technologies during the last decades. Genotyping can be used for a wide range of applications, such as genealogy, assessing risks and causes for common diseases and health conditions, animal and human research, and forensic investigations.
Ingrid Kockum +2 more
wiley +1 more source