The epithelium takes the stage in asthma and inflammatory bowel diseases
Frontiers in Cell and Developmental BiologyThe epithelium is a dynamic barrier and the damage to this epithelial layer governs a variety of complex mechanisms involving not only epithelial cells but all resident tissue constituents, including immune and stroma cells.
Rocío López-Posadas +5 more
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Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery
Advanced Science, EarlyView.Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra +6 more
wiley +1 more source
Characterization of porcine small intestine mucus receptors for the Escherichia coli K88 adhesin
, 1989 John Metcalfe, John Metcalfe
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IL‐1β prevents ILC2 expansion, type 2 cytokine secretion, and mucus metaplasia in response to early‐life rhinovirus infection in mice [PDF]
, 2020 Mingyuan Han +9 more
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Skin Mucus Proteome Analysis Reveals Disease-Resistant Biomarker Signatures in Hybrid Grouper (Epinephelus fuscoguttatus ♀ × Epinephelus lanceolatus ♂) against Vibrio alginolyticus [PDF]
, 2022 Nurhikmah +5 more
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Photocatalytic Micro/Nanomotors Functioning in the Near‐Infrared Window for Biomedical Applications
Advanced Science, EarlyView.This review focuses on near‐infrared responsive photocatalytic micro/nanomotors based on inorganic materials, with particular emphasis on minimally invasive biomedical applications. It discusses material strategies for achieving near‐infrared responsiveness, including heterostructure construction, upconversion nanoparticle integration, defect ...
Yufen Chen +2 more
wiley +1 more source
Bronchial mucus transport velocity in patients receiving anaesthesia with propofol and morphine or propofol and remifentanil [PDF]
, 2006 Thomas Ledowski, S. Hilmi, M. J. Paech
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Advanced Science, EarlyView.Glucuronolactone (GLU) as a natural metabolite of glucose, increases Lactobacillus amylovorus abundance and luminal IAA level to activate AHR signaling. In addition, GLU itself can directly elevate AHR signaling activity independently of microbiota and IAA.
Chenbin Cui +8 more
wiley +1 more source