Results 131 to 140 of about 386,514 (347)

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Airway mucus [PDF]

European Respiratory Journal, 1997
K C, Kim, P K, Jeffery
openaire   +2 more sources

Mucus and mucins in diseases of the intestinal and respiratory tracts

Journal of Internal Medicine, 2019
This review describes the organization and importance of mucus in the intestine and lungs in relation to the diseases cystic fibrosis (CF), ulcerative colitis and chronic obstructive pulmonary disease (COPD).
Gunnar C. Hansson
semanticscholar   +1 more source

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis

Science Translational Medicine, 2019
Increased airway mucus, occurs before infection or structural lung disease in early cystic fibrosis and promotes inflammation. Early changes in cystic fibrosis Cystic fibrosis (CF) is a genetic disorder caused by mutations in the CFTR gene.
C. Esther, M. Muhlebach, C. Ehre, D. Hill, M. Wolfgang, M. Kesimer, K. Ramsey, K. Ramsey, M. Markovetz, Ian C. Garbarine, M. Forest, Ian Seim, Bryan T Zorn, Cameron B. Morrison, M. Delion, William R. Thelin, D. Villalon, J. Sabater, L. Turkovic, S. Ranganathan, S. Stick, S. Stick, R. Boucher   +22 more
semanticscholar   +1 more source

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source

Mucus [PDF]

Proceedings of the Royal Society of Medicine, 1967
  +6 more sources

Giardia spp.-induced microbiota dysbiosis disrupts intestinal mucin glycosylation

Gut Microbes
Infection with the protozoan parasite Giardia duodenalis (syn. intestinalis, lamblia) has been associated with intestinal mucus disruptions and microbiota dysbiosis. The mechanisms remain incompletely understood.
Elena Fekete, Thibault Allain, Olivia Sosnowski, Stephanie Anderson, Ian A. Lewis, Andre G. Buret   +5 more
doaj   +1 more source

Cytokine Storm and Mucus Hypersecretion in COVID-19: Review of Mechanisms

Journal of Inflammation Research, 2021
Mohsin Ali Khan,1 Zaw Ali Khan,1 Mark Charles,2 Pushpendra Pratap,2 Abdul Naeem,2 Zainab Siddiqui,3 Nigar Naqvi,4 Shikha Srivastava4 1Reseach & Development Department, Era’s Lucknow Medical College & Hospital, Lucknow, Uttar Pradesh, India;
Khan MA, Khan ZA, Charles M, Pratap P, Naeem A, Siddiqui Z, Naqvi N, Srivastava S   +7 more
doaj  

Cohort Efficacy Study of Natural Family Planning among Perimenopause Age Women [PDF]

, 2014
Objective: To determine the efficacy of using natural family planning (NFP) methods to avoid unintended pregnancy among women of perimenopause age (i.e., age 40-55 years).
Fehring, Richard, Mu, Qiyan
core   +1 more source