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Cell, 2022 Neuroepithelial crosstalk is critical for gut physiology. However, the mechanisms by which sensory neurons communicate with epithelial cells to mediate gut barrier protection at homeostasis and during inflammation are not well understood.
Kimberly Meerschaert +2 more
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Mucus Penetration of Surface-Engineered Nanoparticles in Various pH Microenvironments.
ACS Nano, 2023The penetration behavior of nanoparticles in mucous depends on physicochemical properties of the nanoparticles and the mucus microenvironment, due to particle-mucin interactions and the presence of the mucin mesh space filtration effect.
Yiyang Guo +8 more
semanticscholar +1 more source
Immunological aspects of intestinal mucus and mucins
Nature Reviews Immunology, 2016 Malin E V Johansson, Gunnar C Hansson
exaly +2 more sources
Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation
Science immunology, 2022Goblet cells and their main secretory product, mucus, play crucial roles in orchestrating the colonic host-microbe interactions that help maintain gut homeostasis.
Jian Zhang +17 more
semanticscholar +1 more source
American Journal of Respiratory and Critical Care Medicine, 2022
RATIONALE Cross-sectional analysis of mucus plugs in computed tomography (CT) lung scans in the Severe Asthma Research Program (SARP)-3 showed a high mucus plug phenotype.
Monica Tang +24 more
semanticscholar +1 more source
RATIONALE Cross-sectional analysis of mucus plugs in computed tomography (CT) lung scans in the Severe Asthma Research Program (SARP)-3 showed a high mucus plug phenotype.
Monica Tang +24 more
semanticscholar +1 more source
ACS Biomaterials Science & Engineering, 2022
Mucus is a complex viscoelastic gel and acts as a barrier covering much of the soft tissue in the human body. High vascularization and accessibility have motivated drug delivery to various mucosal surfaces; however, these benefits are hindered by the ...
Jeffrey Watchorn +5 more
semanticscholar +1 more source
Mucus is a complex viscoelastic gel and acts as a barrier covering much of the soft tissue in the human body. High vascularization and accessibility have motivated drug delivery to various mucosal surfaces; however, these benefits are hindered by the ...
Jeffrey Watchorn +5 more
semanticscholar +1 more source
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
Advanced Drug Delivery Reviews, 2009 Samuel K Lai
exaly +2 more sources
Respiration, 1991
Until recently the experimental and clinical possibilities for investigation of the pharmacological effects of drugs acting on airway secretions were limited. Nowadays, new biological, physical and chemical techniques of investigation are applied to 'mucology', providing better characterization of this class of drugs.
openaire +2 more sources
Until recently the experimental and clinical possibilities for investigation of the pharmacological effects of drugs acting on airway secretions were limited. Nowadays, new biological, physical and chemical techniques of investigation are applied to 'mucology', providing better characterization of this class of drugs.
openaire +2 more sources
Acta Pharmaceutica Sinica B
The intestinal mucus barrier is an important line of defense against gut pathogens. Damage to this barrier brings bacteria into close contact with the epithelium, leading to intestinal inflammation.
Yumeng Wang +6 more
semanticscholar +1 more source
The intestinal mucus barrier is an important line of defense against gut pathogens. Damage to this barrier brings bacteria into close contact with the epithelium, leading to intestinal inflammation.
Yumeng Wang +6 more
semanticscholar +1 more source