Results 41 to 50 of about 388,969 (398)

Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon [PDF]

, 2015
Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits epithelial damage and compensatory hyperproliferation, leading to hyperplasia.
Clara Belzer, Giovannucci, Guido J. Hooiveld, Jan Dekker, Lapré, McGarr, Michael Müller, Michiel Kleerebezem, Noortje Ijssennagger, Roelof van der Meer, Saskia W. C. van Mil, Sesink, Sheffner, van Klinken   +13 more
core   +2 more sources

Tuning gastropod locomotion: Modeling the influence of mucus rheology on the cost of crawling [PDF]

, 2006
Common gastropods such as snails crawl on a solid substrate by propagating muscular waves of shear stress on a viscoelastic mucus. Producing the mucus accounts for the largest component in the gastropod's energy budget, more than twenty times the amount ...
A. E. Hosoi, Buyssens N., Davies M. S., Davies M. S., Denny M. W., Denny M. W., Denny M. W., Denny M. W., Denny M. W., Deyrupolsen I., Donovan D. A., Eric Lauga, Farmer W. M., Fretter V., Gainey L. F., Gray J., Jones H. D., Kideys A. E., Lissmann H. W., Lissmann H. W., Miller S. L., Moffett S., Morton J. E., Morton J. E., Parker G. H., Trueman E. R., Vlès F.   +26 more
core   +2 more sources

Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis

Gut, 2019
Objective The colonic inner mucus layer protects us from pathogens and commensal-induced inflammation, and has been shown to be defective in active UC.
Sjoerd van der Post, Karolina S. Jabbar, G. Birchenough, L. Arike, N. Akhtar, Henrik Sjovall, M. Johansson, G. Hansson   +7 more
semanticscholar   +1 more source

Release of Lungworm Larvae from Snails in the Environment: Potential for Alternative Transmission Pathways [PDF]

, 2015
Background: Gastropod-borne parasites may cause debilitating clinical conditions in animals and humans following the consumption of infected intermediate or paratenic hosts.
A Di Cesare, A Giannelli, A Giannelli, AJ Norton, Alessio Giannelli, Antonio Varcasia, C Tamponi, CA Waugh, CB Gerichter, CL Mendonça, CLGF Mendonça, CM Adema, CY Yii, D Heyneman, D Otranto, DH Molyneux, Domenico Otranto, DU Olveda, E Brianti, E Brianti, Emanuele Brianti, ER Morgan, Filipe Dantas-Torres, Francesca Abramo, G Annoscia, I Paperna, JE Ubelaker, JL Teem, Luigi Falsone, M Campion, Mark T. Fox, Martin Knaus, Matty Knight, P Seneviratna, QP Wang, RA Ramos, Rafael Antonio do Nascimento Ramos, RC Anderson, RH Cowie, SC Thiengo, SJ Kutz, SN Boev, SS Wu, TA Barçante, TC Cheng, TM Caro, TM Caro, TN Petney, TP Ng, VC Bonetti, Vito Colella, W Jeżewski   +51 more
core   +5 more sources

Acute Respiratory Barrier Disruption by Ozone Exposure in Mice

Frontiers in Immunology, 2019
Ozone exposure causes irritation, airway hyperreactivity (AHR), inflammation of the airways, and destruction of alveoli (emphysema), the gas exchange area of the lung in human and mice.
Milena Sokolowska, Milena Sokolowska, Valerie F. J. Quesniaux, Cezmi A. Akdis, Cezmi A. Akdis, Kian Fan Chung, Bernhard Ryffel, Dieudonnée Togbe, Dieudonnée Togbe   +8 more
doaj   +1 more source

Targeting TL1A/DR3 Signaling Offers a Therapeutic Advantage to Neutralizing IL13/IL4Rα in Muco-Secretory Fibrotic Disorders

Frontiers in Immunology, 2021
Mucus secretion is an important feature of asthma that highly correlates with morbidity. Current therapies, including administration of mucolytics and anti-inflammatory drugs, show limited effectiveness and durability, underscoring the need for novel ...
Hope Steele, Kacey Sachen, Andrew J. McKnight, Rachel Soloff, Rana Herro, Rana Herro   +5 more
doaj   +1 more source

Association of allergen signatures with individualized allergic phenotypes

Allergology International
Background: Allergen sensitization patterns are heterogeneous, and their clinical relevance is often obscured by extensive cross-reactivity. We applied non-negative matrix factorization (NMF) to disentangle overlapping immunoglobulin E (IgE) signals and ...
Dachan Kim, Hyung-Ju Cho, Chang-Hoon Kim, Min-Seok Rha   +3 more
doaj   +1 more source

Ductal Mucus Obstruction and Reduced Fluid Secretion Are Early Defects in Chronic Pancreatitis

Frontiers in Physiology, 2018
Objective: Defective mucus production in the pancreas may be an important factor in the initiation and progression of chronic pancreatitis (CP), therefore we aimed to (i) investigate the qualitative and quantitative changes of mucus both in human CP and ...
Anita Balázs, Anita Balázs, Zsolt Balla, Balázs Kui, József Maléth, József Maléth, Zoltán Rakonczay, Julia Duerr, Julia Duerr, Zhe Zhou-Suckow, Jolanthe Schatterny, Matthias Sendler, Julia Mayerle, Jens-P. Kühn, László Tiszlavicz, Marcus A. Mall, Marcus A. Mall, Marcus A. Mall, Peter Hegyi, Peter Hegyi, Peter Hegyi   +20 more
doaj   +1 more source

Mucus fishing syndrome

BMJ Case Reports, 2022
Mucus fishing syndrome is a chronic inflammatory ocular surface condition characterised by repetitive self-extraction of mucous strands from the eye. A man in his 30s presented with bilateral ocular redness, itch, irritation, tearing and sticky mucoid discharge for 3 months.
Ryan L. J. Chiew, Denise T. M. Au Eong, Kah Guan Au Eong   +2 more
openaire   +4 more sources

Lamellar Structures of MUC2-Rich Mucin: A Potential Role in Governing the Barrier and Lubricating Functions of Intestinal Mucus [PDF]

, 2012
Mucus is a ubiquitous feature of mammalian wet epithelial surfaces, where it lubricates and forms a selective barrier that excludes a range of particulates, including pathogens, while hosting a diverse commensal microflora.
Garcia De La Torre, Angela, MacIerzanka, Adam, MacKie, Alan R., Mills, Clare, Mills, E. N Clare, Rigby, Neil M., Round, Andrew N.   +6 more
core   +1 more source