Cathelicidin regulates goblet cell mucus secretion and mucus-associated proteins in Citrobacter rodentium-induced colitis [PDF]
Gut MicrobesColonic goblet cells play a crucial role in mucosal defense by secreting Muc2 mucin and other proteins that entrap and expel enteropathogens. However, the role of innate effectors in the gut like cathelicidin peptides in regulating the mucus barrier ...
Niloofar Mirzadzare +12 more
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Stressing out over mucus secretion [PDF]
Cell Host & Microbe, 2023 In this issue of Cell Host & Microbe, Naama et al. show that autophagy controls mucus secretion in the colons of mice. They demonstrate that autophagy reduces ER stress in mucus-producing goblet cells to enhance mucus production, which shapes the gut microbial community and protects against colitis.
Grey MJ.
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Rhubarb-Evoke Mucus Secretion through Aggregation and Degranulation of Mast Cell in the Colon of Rat: In vivo and ex vivo studies [PDF]
Sci Rep, 2019 Rhubarb is commonly used to treat constipation in China for its function of promoting intestinal movement and optimum water content in feces. However, its mechanism of mucus secretion is vague.
Di Wu +8 more
semanticscholar +2 more sources
Discovery of Fungus-Derived Nornidulin as a Novel TMEM16A Inhibitor: A Potential Therapy to Inhibit Mucus Secretion in Asthma [PDF]
Journal of Experimental Pharmacology, 2023 Pawin Pongkorpsakol,1,* Chantapol Yimnual,2,* Wilasinee Satianrapapong,3 Nichakorn Worakajit,4 Suchada Kaewin,2 Praphatsorn Saetang,5 Vatcharin Rukachaisirikul,5 Chatchai Muanprasat2 1Princess Srisavangavadhana College of Medicine, Chulabhorn ...
Pongkorpsakol P +7 more
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Stress-Induced Mucus Secretion and Its Composition by a Combination of Proteomics and Metabolomics of the Jellyfish Aurelia coerulea [PDF]
Mar Drugs, 2018 Background: Jellyfish respond quickly to external stress that stimulates mucus secretion as a defense. Neither the composition of secreted mucus nor the process of secretion are well understood.
Wenwen Liu +10 more
semanticscholar +2 more sources
CeO2 nanoparticles attenuate airway mucus secretion induced by TiO2 nanoparticles [PDF]
Sci Total Environ, 2018 Nanotoxicity studies associated with various nanoparticles (NPs) have attracted intense research interest due to the broader applications of nanoparticles in our daily lives.
S. Tsai +8 more
semanticscholar +2 more sources
Novel Human NKCC1 Mutations Cause Defects in Goblet Cell Mucus Secretion and Chronic InflammationSummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2020 Background & Aims: Infections resulting from intestinal yeast and bacteria affect a large number of patients with deficits in absorptive or secretory epithelial transport mechanisms.
Rainelli Koumangoye +3 more
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Coordinated regulation of colonic fluid and mucus secretion [PDF]
Frontiers in PharmacologyThe human colon, unlike the small intestine which is relatively sterile, contains a diverse microbiome which contributes to host metabolism. The luminal environment is constantly changing and responds to epithelial absorption and secretion which occurs ...
Alan W. Baird
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Acta Pharmaceutica Sinica BThe intestinal mucus barrier is an important line of defense against gut pathogens. Damage to this barrier brings bacteria into close contact with the epithelium, leading to intestinal inflammation.
Yumeng Wang +6 more
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Xenopus: An alternative model system for identifying muco-active agents. [PDF]
PLoS ONE, 2018 The airway epithelium in human plays a central role as the first line of defense against environmental contaminants. Most respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, and respiratory infections, disturb normal muco ...
Hyo Jung Sim +5 more
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