Results 41 to 50 of about 851,832 (288)
TMEM16A in Cystic Fibrosis: Activating or Inhibiting?
Frontiers in Pharmacology, 2019 The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction.
Karl Kunzelmann +8 more
doaj +1 more source
VAMP8 mucin exocytosis attenuates intestinal pathogenesis by Entamoeba histolytica
Microbial Cell, 2017 The intestinal mucosa encounters a barrage of ingested insults within the host yet under homeostasis elegantly facilitates nutrient absorption and sustenance of the commensal microbiota. An essential defence mechanism employed by the host is limiting the
Steve Cornick +3 more
doaj +1 more source
Dynamic changes in mucus thickness and ion secretion during Citrobacter rodentium infection and clearance. [PDF]
PLoS ONE, 2013 Citrobacter rodentium is an attaching and effacing pathogen used as a murine model for enteropathogenic Escherichia coli. The mucus layers are a complex matrix of molecules, and mucus swelling, hydration and permeability are affected by many factors ...
Jenny K Gustafsson +9 more
doaj +1 more source
A crucial role of Flagellin in the induction of airway mucus production by Pseudomonas aeruginosa. [PDF]
PLoS ONE, 2012 Pseudomonas aeruginosa is an opportunistic pathogen involved in nosocomial infections. Flagellin is a P. aeruginosa virulence factor involved in host response to this pathogen. We examined the role of flagellin in P.
Fatima Ben Mohamed +6 more
doaj +1 more source
Ductal Mucus Obstruction and Reduced Fluid Secretion Are Early Defects in Chronic Pancreatitis
Frontiers in Physiology, 2018 Objective: Defective mucus production in the pancreas may be an important factor in the initiation and progression of chronic pancreatitis (CP), therefore we aimed to (i) investigate the qualitative and quantitative changes of mucus both in human CP and ...
Anita Balázs +20 more
doaj +1 more source
Entamoeba histolytica Cysteine Proteinase 5 Evokes Mucin Exocytosis from Colonic Goblet Cells via αvβ3 Integrin. [PDF]
PLoS Pathogens, 2016 Critical to the pathogenesis of intestinal amebiasis, Entamoeba histolytica (Eh) induces mucus hypersecretion and degrades the colonic mucus layer at the site of invasion.
Steve Cornick +2 more
doaj +1 more source
Mediators of Inflammation, 2016 Mucus secretion is often uncontrolled in many airway inflammatory diseases of humans. Identifying the regulatory pathway(s) of mucus gene expression, mucus overproduction, and hypersecretion is important to alleviate airway inflammation in these diseases.
Jee-Yeong Jeong +8 more
doaj +1 more source
Biomolecules & Therapeutics, 2020 Hypersecretion of pulmonary mucus is a major pathophysiological feature in allergic and inflammatory respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD).
Xin Li +3 more
semanticscholar +1 more source
Excess Secretion of Gel-Forming Mucins and Associated Innate Defense Proteins with Defective Mucin Un-Packaging Underpin Gallbladder Mucocele Formation in Dogs. [PDF]
PLoS ONE, 2015 Mucosal protection of the gallbladder is vital yet we know very little about the mechanisms involved. In domestic dogs, an emergent syndrome referred to as gallbladder mucocele formation is characterized by excessive secretion of abnormal mucus that ...
Mehmet Kesimer +6 more
doaj +1 more source
Nature Communications, 2023 This study offers molecular insight into the sialidase and fucosidase decapping apparatus that initiates growth on mucin and promotes nutrient sharing by the dedicated mucolytic symbiont Akkermansia muciniphila with the mucus-associated microbiota.
Bashar Shuoker +14 more
semanticscholar +1 more source