Results 51 to 60 of about 851,832 (288)

Azithromycin Inhibits Mucus Hypersecretion from Airway Epithelial Cells

Mediators of Inflammation, 2012
To examine the in vivo effects of the 15-member macrolide, azithromycin (AZM), on mucus hypersecretion, we induced hypertrophic and metaplastic changes of goblet cells in rat nasal epithelium by intranasal instillation of ovalbumin (OVA) in OVA ...
Takeshi Shimizu, Shino Shimizu
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Synergistic mucus secretion by histamine and IL-4 through TMEM16A in airway epithelium.

American Journal of Physiology - Lung cellular and Molecular Physiology, 2017
Histamine is an important mediator of allergic reactions, and mucus hypersecretion is a major allergic symptom. However, the direct effect of histamine on mucus secretion from airway mucosal epithelia has not been clearly demonstrated.
Ju Wan Kang, Yong Hyuk Lee, Min Jeong Kang, Hyun Jae Lee, Ryungha Oh, Hyun Jin Min, W. Namkung, J. Choi, Sang Nam Lee, C. Kim, Joo-Heon Yoon, Hyung-Ju Cho   +11 more
semanticscholar   +1 more source

Safety of Prescription Nonsteroidal Anti‐inflammatory Drugs in Adults With Inflammatory Bowel Disease: Data From a Large Administrative Claims Cohort

Arthritis Care &Research, EarlyView.
Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer, Rui Xiao, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +4 more
wiley   +1 more source

Neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis

Respiratory Research, 2018
The nervous system mediates key airway protective behaviors, including cough, mucus secretion, and airway smooth muscle contraction. Thus, its involvement and potential involvement in several airway diseases has become increasingly recognized.
Kalina R. Atanasova, Leah R. Reznikov
doaj   +1 more source

Nanofiber‐Supported Decellularized Matrix Membrane Creates a Biomimetic Biochemical and Biophysical Niche for Intestinal Organoid Epithelium

Advanced Healthcare Materials, EarlyView.
A nanofiber‐supported decellularized extracellular matrix (NaDE) membrane recreates key biochemical and mechanical features of native intestinal tissue. This platform enables the formation of a more physiologically relevant intestinal epithelium, enhancing stem cell maintenance and promoting diverse cell differentiation.
Jaeseung Youn, Hyeonji Kim, Nam Than, Juhyeok Kim, Jangwon Yoon, Dohui Kim, Hyun Jung Kim, Dong Sung Kim   +7 more
wiley   +1 more source

Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection

Cell, 2022
Summary Neuroepithelial crosstalk is critical for gut physiology. However, the mechanisms by which sensory neurons communicate with epithelial cells to mediate gut barrier protection at homeostasis and during inflammation are not well understood.
Daping Yang, A. Jacobson, Kimberly A. Meerschaert, Joseph J. Sifakis, Meng Wu, X. Chen, Tiandi Yang, Youliang Zhou, P. Anekal, RA Rucker, Deepika Sharma, Alexandra Sontheimer-Phelps, Glendon Wu, Liwen Deng, M. D. Anderson, Samantha Choi, Dylan V. Neel, N. Lee, Dennis L. Kasper, B. Jabri, Jun R. Huh, M. Johansson, Jay R. Thiagarajah, Samantha J. Riesenfeld, Isaac M. Chiu   +24 more
semanticscholar   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Creation of a spatially complex mucus bilayer on an in vitro colon model

Scientific Reports
The colonic epithelium is comprised of three-dimensional crypts (3D) lined with mucus secreted by a heterogeneous population of goblet cells. In this study, we report the formation of a long-lived, and self-renewing replica of human 3D crypts with a ...
Cecilia Villegas-Novoa, Yuli Wang, Christopher E. Sims, Nancy L. Allbritton   +3 more
doaj   +1 more source

Lyn regulates mucus secretion and MUC5AC via the STAT6 signaling pathway during allergic airway inflammation

Scientific Reports, 2017
Hypersecretion of mucus is an important component of airway remodeling and contributes to the mucus plugs and airflow obstruction associated with severe asthma phenotypes. Lyn has been shown to down-regulate allergen-induced airway inflammation. However,
Xiaoyun Wang, Yin Li, D. Luo, Xing Wang, Yun Zhang, Zhi-gang Liu, N. Zhong, Min Wu, Guoping Li   +8 more
semanticscholar   +1 more source