Results 191 to 200 of about 104,669 (254)

Elevated CO2 and Temperature Alter Grass Pollen's Ability to Modify Transcriptome and Function of the Nasal Epithelium

Allergy, EarlyView.
We exposed human nasal epithelial tissues to pollen from grasses grown under different climate treatments (temperature and CO2). Pollen weakened epithelial tight junctions and altered cytokine‐related gene expression, with similar protein‐level effects.
Tarleena Tossavainen, Tanja Turunen, Maria‐Viola Martikainen, Miisa Kankaanpää, Marjo Malinen, Marjut Roponen   +5 more
wiley   +1 more source

Nasal Airway Transcriptome Reflects Selected Asthma‐Associated Gene Signatures in the Lower Airways

Allergy, EarlyView.
Seven genes and two gene modules were consistently associated with asthma in both airway compartments in ARMS and were validated in ATLANTIS. The two modules reflected IL‐13 related inflammation and mast cell activity, respectively. Nasal gene signatures provide a non‐invasive proxy for selected bronchial asthma‐associated gene signatures. ARMS, Asthma
Hui Wen, Tessa Kole, Orestes A. Carpaij, Tatiana Karp, Victor Guryev, Alen Faiz, Kian Fan Chung, Pankaj Bhavsar, Ian M. Adcock, Salman Siddiqui, Andy Lan, Katie L. Raby, Nazanin Zounemat‐Kermani, Chris Brightling, Dave Singh, Janwillem Kocks, Monica Kraft, Bianca Beghé, Klaus F. Rabe, Alberto Papi, Machteld N. Hylkema, Martijn C. Nawijn, Maarten van den Berge   +22 more
wiley   +1 more source

MAIT Cells Suppress IgE‐Mediated Asthma via IFNγ‐Dependent B Cell Regulation

Allergy, EarlyView.
In this study, we demonstrate that MAIT cell antagonism during sensitization and challenge with HDM worsens the development of airway hyperreactivity without effects on type 2 or 17 associated cytokine production or lung inflammation. Rather, MAIT cells appear to regulate HDM‐induced asthma through direct inhibition of IgE production.
Angela M. Cannata, Jaclyn W. McAlees, Julie M. Hargis, Archana Shankar, Shouxiong Huang, Senad Divanovic, Ian P. Lewkowich   +6 more
wiley   +1 more source

Is Asthma Remission a New Achievable Goal? A Review of the Current Drug‐Related Evidence and Predictors

Allergy, EarlyView.
ABSTRACT Advances in asthma therapies have shown that clinical remission may be an achievable therapeutic goal for patients with asthma. This review discusses the current definitions of remission in asthma, the predictors of remission, airway inflammation/epithelial damage in asthma remission, airway remodeling, paradigms in defining remission and ...
Fatma Esra Gunaydin, Giulia Marcassa, Bianca Olivieri, Gianenrico Senna, Marco Caminati   +4 more
wiley   +1 more source

Effect of Dupilumab on Airway Inflammation in Patients With Persistent Asthma

Allergy, EarlyView.
EXPEDITION (NCT02573233) assessed the effects of dupilumab on airway inflammation in patients with persistent asthma using bronchoscopy and gene expression analysis. Dupilumab showed no appreciable effect on inflammatory cell types in biopsies or BALF samples.
Michael E. Wechsler, Sally E. Wenzel, Steve D. Groshong, Mario Castro, Ian D. Pavord, Klaus F. Rabe, Elizabeth Laws, Alexandre Jagerschmidt, Kaitlyn Gayvert, Sivan Harel, Jennifer D. Hamilton, Nikhil Amin, Lu Zhang, Heming Xing, Anissa Elfakir, Bema Coulibaly, Souâd Naimi, Sara Hamon, Paul J. Rowe, Frank Nestle, Danen M. Cunoosamy, Emanuele de Rinaldis, Leda P. Mannent   +22 more
wiley   +1 more source

Differential Roles for IL‐4Rα and IL‐13Rα1 in Immune Cell Infiltration and Epithelial Remodeling in Experimental Eosinophilic Gastritis

Allergy, EarlyView.
This study described the development of an experimental model for eosinophilic gastritis (EoG). Experimental EoG recapitulates histopathological features of human disease. including foveolar elongation, fibrosis, eosinophilia, mastocytosis and shared transcriptional programs.
Anish Dsilva, Shraddha Sharma, Shireen Barakey, Ariel Wagner, Alice Keisar, Tali Bar‐on, Michal Itan, Ariel Munitz   +7 more
wiley   +1 more source

Surgical Management of Non‐Allergic Rhinitis—An EAACI Task Force Position Paper

Allergy, EarlyView.
ABSTRACT Non‐allergic rhinitis is a frequent yet underdiagnosed cause of chronic nasal symptoms, including nasal congestion, rhinorrhoea, and upper airway hyperreactivity. Its pathophysiology involves neurogenic dysregulation, leading to excessive mucus production and vasodilation.
Marie Lundberg, Julie van Waterschoot, Mathilde Moyaert, Adam Chaker, Philippe Gevaert, Jan Hagemann, Valérie Hox, Maarten Kleijwegt, Ludger Klimek, Devyani Lal, Juan Maza‐Solano, Oliver Pfaar, Fabio Simon Ryser, Michele Shiappoli, Diana Silva, Sanna Toppila‐Salmi, Johanna Wikstén, Sietze Reitsma, Laura Van Gerven   +18 more
wiley   +1 more source

Diet–Microbiome–Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications

Allergy, EarlyView.
ABSTRACT Mucosal surfaces are sites of highly dynamic interactions among epithelial and immune cells, environmental exposures, particularly dietary inputs, and the diverse microbial communities and their metabolites. These elements continually influence each other to maintain homeostasis and ensure appropriate immune discrimination between pathogens ...
Clara Delaroque, Liam O'Mahony, Inge Kortekaas Krohn, Charlotte G. Mortz, Markus Ollert, Mahesh S. Desai   +5 more
wiley   +1 more source

Deficiency of Mitochondrial Fatty Acid Enzyme, CPT1A, Underlies Airway Epithelial Barrier Dysfunction in Severe Asthma

Allergy, EarlyView.
Mitochondrial fatty acid enzyme, CPT1A, is deficient in the airway epithelium of severe asthma patients. Restoration of CPT1A expression improved epithelial barrier integrity via increasing mitochondrial respiration and ATP production in airway epithelial cells. Restoration of deficient epithelial CPT1A may represent a new treatment approach for severe
Muyun Wang, Haiyang Hu, Kun Wang, Di Wu, Ximing Liao, Jing Gao, Tian Li, Wujian Xu, Shaoyong Gao, Qiang Li, Pankaj Kumar Bhavsar, Wei Gao, Kian Fan Chung   +12 more
wiley   +1 more source

Gastric stimulation and secretion of mucus.

BMJ, 1983
openaire   +3 more sources